In vivo abrogation of serum C3 and C5 by administration of cobra venom factor and heterologous anti-C3

Drake, Walter P.; Pokorney, Dale R.; Mardiney, Michael R.

doi:10.1016/0022-1759(74)90090-8

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1984

2005

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Cited by 4 publications

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“…Our results suggest that complement plays a crucial role in the prevention of syphilis. CVF activates and depletes C3 (7,8), and C3b receptors are found on granulocytes and mononuclear phagocytes (10,19,23, 27, 34) that actively participate in destruction of pathogens. Depletion of complement could account for the enhanced progression of syphilitic lesions in CVF-treated animals.…”

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confidence: 99%

Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters

Azadegan¹,

Tabor²,

Schell³

et al. 1984

Infect Immun

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Cobra venom factor, an agent commonly used to deplete complement, lowered the resistance of hamsters to infection with Treponema pallidum subsp. endemicum, as shown by a more rapid development of cutaneous lesions in infected animals treated with cobra venom factor than in infected, untreated animals. Cobra venom factor also abrogated the passive transfer of resistance by injection of serum from syphilitic immune hamsters. These results indicate that complement influences the pathogenesis of treponemal infection.

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confidence: 99%