In Vivo Activity of Benzoyl Ester Clerodane Diterpenoid Derivatives from <i>Dodonaea polyandra</i>

Simpson, Bradley S.; Claudie, David; Gerber, Jacobus P.; Pyke, Simon M.; Wang, Jiping; Semple, Susan J.

doi:10.1021/np100701s

Cited by 26 publications

(20 citation statements)

References 18 publications

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“…This species grows within a localized region of tropical Cape York Peninsula, Queensland. The findings demonstrated that a male individual of D. polyandra consisted of labdane diterpenoids as major constituents [23] in contrast to the female which possessed clerodane diterpenoids [24]. A more commonly researched and related species, Dodonae aviscosa (Sapindaceae), is also dioecious (along with many other species in this genus), however there has been no distinction made between the phytochemistry of male and female plants.…”

Section: Effect On Secondary Metabolite Productionmentioning

confidence: 99%

Dioecy in Plants - Is It an Important Factor for Phytochemists to Consider?

Simpson

2013

Planta Med

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Section: Effect On Secondary Metabolite Productionmentioning

confidence: 99%

Dioecy in Plants - Is It an Important Factor for Phytochemists to Consider?

Simpson

2013

Planta Med

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“…1). Each of the isolated compounds possesses a labdane skeleton, which is in contrast to the clerodane diterpenoids reported recently from the same plant species (Simpson et al, 2011a). The following paragraphs report the structural elucidation of the new compounds isolated.…”

Section: Resultsmentioning

confidence: 86%

“…However, diterpenoids previously isolated from D. polyandra have all contained a clerodane skeleton (Simpson et al, 2011a). Labdane and clerodane classes are biosynthetically related via a series of methyl and hydride shifts (George et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Rare, seven-membered cyclic ether labdane diterpenoid from Dodonaea polyandra

et al. 2012

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Previous phytochemical studies on the leaf resin of dioecious plant species Dodonaea polyandra have identified the presence of furanoclerodane diterpenoids. As part of ongoing research on this species the chemical profile of an individual plant displaying male flowers was investigated. Repeated chromatographic separation of a resinous extract from the leaves of the plant yielded three labdane diterpenoids, 13,17-epoxy-13-methyl-15-oxo-labda-7-ene (1), 17-hydroxy-13-methyl-labda-7,13Z-diene-15-oic acid (2) and 13-methyl-17-oxo-labda-7,13Z-diene-15-oic acid (3) and a fourth known labdane diterpenoid (4) reported as being isolated from a natural source for the first time. Structural elucidation was carried out using conventional 1D and 2D NMR and mass spectrometry together with other complementary techniques (UV and IR). The leaf extract from this individual of D. polyandra with male flowers present displays a marked difference in the chemical composition of diterpenoids compared to previously studied extracts from the leaves of this species.

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“…The bioactivity was concentrated to within a small number of subfractions obtained from chromatographic separation processes of the extract. Eventually, four benzoyl ester furanoclerodane diterpenoids were isolated, of which three were established as contributing a major part of the anti-inflammatory effects of the plant (47).…”

Section: Kuuku I'yu Medicinal Plant Projectmentioning

confidence: 99%

Learning from Both Sides: Experiences and Opportunities in the Investigation of Australian Aboriginal Medicinal Plants

Simpson¹,

Claudie

Smith³

et al. 2013

J Pharm Pharm Sci

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-With one of the oldest surviving cultures in the world, Australian Aboriginal people have developed immense knowledge about the diverse Australian flora. Western scientific investigation of some Australian Aboriginal medicinal plants has demonstrated interesting pharmacological activities and chemistry, however the majority of these species have not yet been extensively examined. We argue that research that is locally initiated and driven by Indigenous traditional owners in collaboration with Western scientists has significant potential to develop new plant-based products. Locally driven medicinal plants research in which traditional owners work as researchers in collaboration with University-based colleagues in the investigation of medicines rather than "stakeholders" or "informants" is one model that may be used in characterising plants with the potential to be developed into sustainable plant-based medicinal products with commercial value. Our team has taken this approach in research located both on traditional homelands and in the laboratory.

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In Vivo Activity of Benzoyl Ester Clerodane Diterpenoid Derivatives from Dodonaea polyandra

Cited by 26 publications

References 18 publications

Dioecy in Plants - Is It an Important Factor for Phytochemists to Consider?

Dioecy in Plants - Is It an Important Factor for Phytochemists to Consider?

Rare, seven-membered cyclic ether labdane diterpenoid from Dodonaea polyandra

Learning from Both Sides: Experiences and Opportunities in the Investigation of Australian Aboriginal Medicinal Plants

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