Matricaria chamomilla contained oils, sterols, triterpenes, flavonoids, saponins, tannins, alkaloids, sugars, proteins, mucins, sesquiterpenes, coumarins, polyacetylenes, phenyl carboxylic acids, amino acids, phytosterols, choline and mineral substances. The pharmacological studies revealed that Matricaria chamomilla possessed dermatological, antioxidant, anticancer, anti-inflammatory, analgesic, antimicrobial, reproductive, antiulcerogenic, antidiarrheal, antispasmodic, antidiabetic, antiparasitic, antiallergic, protective, anxiolytic, sedative, antidepressant, anticonvulsant, hypotensive, hypolipidemic, memory enhancing and many other effects. This review was designed to highlight thechemicalconstituents andpharmacological effects of Matricaria chamomilla.