In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

Uddin, Mir Mn; Ahmed, Shahriar; Kabir, Muhammad Sani; Rahman, Mohammad Shafiqur; Sultan, Ramiz Ahmed; Emran, Talha Bin

doi:10.7324/japs.2017.70114

Cited by 11 publications

(12 citation statements)

References 16 publications

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“…are very crucially affected by the human health [24]. Medicinal plants are used to treat a lot of psychiatric disorders through their potential active phytochemicals [25] which have fewer side effects [26]. Since synthetic drugs reduce these disorders with a great number of side effects and sometimes they create addiction over these drugs which causes suicide [27].…”

Section: Discussionmentioning

confidence: 99%

“…Bioactive compounds are obtained from medicinal plants that should be regulated and inhibit the abnormal release of neurotransmitters [42]. Additionally, in the secondary metabolites of C. velutina leaves, we tested a few qualitative phytochemical screenings where we found some chemical compounds such as resin, phenol, tannin, alkaloid, carbohydrate, and glycosides which played a great role as a psychiatric drug [22,25]. In our study, we evaluated MECVL as a neuropsychiatric drug through several animal models against depression, anxiety, and insomnia where the phytochemicals such as resin, phenol, tannin, alkaloid, carbohydrate, and glycoside played a significant role by binding with protein complexes.…”

Section: Discussionmentioning

confidence: 99%

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GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

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Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

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“…In addition, to treat diabetic hyperglycemia in either long or short duration, a number of natural compounds have been identified with their different mechanisms. S-methyl cysteine sulfoxide ( Allium cepa L.) [ 326 ], lophenol ( Aloe vera L.) [ 327 ], and gymnemic acids ( Gymnema sylvestre R.) [ 328 , 329 ] contribute significant effect on insulin secreting beta cells. While S-allyl cysteine ( Allium sativum L.) [ 330 ], insulin like protein or so called plant insulin ( Momordica charantia L.) act as alternatives to insulin, tetrahydrocurcumin ( Curcuma longa L.) displays its activity by modifying glucose utilization [ 331 ], and 4-hydroxyisoleucine, a novel amino acid potentiator of insulin secretion derived from Trigonella foenum-graecum L. [ 332 ].…”

Section: Future Prospects For Antidiabetic Plant Researchmentioning

confidence: 99%

Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review

Rahman

Uddin

Reza

et al. 2021

Plants

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The use of conventional drugs to treat metabolic disorders and the pathological consequences of diabetes further increases the complications because of the side effects, and is sometimes burdensome due to relatively higher costs and occasionally painful route of administration of these drugs. Therefore, shifting to herbal medicine may be more effective, economical, have fewer side effects and might have minimal toxicity. The present review amasses a list of ethnomedicinal plants of 143 species belonging to 61 families, from distinctive domestic survey literature, reported to have been used to treat diabetes by the ethnic and local people of Bangladesh. Leaves of the medicinal plants were found leading in terms of their use, followed by fruits, whole plants, roots, seeds, bark, stems, flowers, and rhizomes. This review provides starting information leading to the search for and use of indigenous botanical resources to discover bioactive compounds for novel hypoglycemic drug development.

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“…Carrageenan-induced paw edema test is a wellestablished and most widely used test to evaluate the anti-inflammatory potential of plants and drugs [43,44]. Inflammation is a complex process as it involves the activation of various mediators like prostaglandins, kinins, platelet activating factors, leukotrienes, neutrophils and several cytokines including interleukins and tumor necrosis factors [45].…”

Section: In Silico Molecular Docking Analysismentioning

confidence: 99%

In vivo and in vitro pharmacological activities of Tacca integrifolia rhizome and investigation of possible lead compounds against breast cancer through in silico approaches

Ahmed

Rakib

et al. 2019

Clin Phytosci

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Background: The study was conducted to evaluate the analgesic, anti-inflammatory, antipyretic properties of ethanolic extract of Tacca integrifolia rhizome (EETI) in mice and cytotoxic effects in brine shrimp nauplii followed by a PASS prediction study for some isolated compounds of T. integrifolia. Additionally, this experiment included the in silico molecular docking and ADME/T property analyses of some phytochemicals. Methods: Formalin-induced paw licking test and acetic acid-induced writhing test for analgesic activity, carrageenaninduced paw edema test for anti-inflammatory potential and Brewer's yeast-induced pyrexia test for antipyretic activity were applied. Antinociceptive and antineoplastic activity for breast cancer were revealed with PASS program. Schrodinger suite 2015 was used to evaluate the binding interaction and ADME/T properties of selected phytoconstituents with estrogen receptor alpha. Results: In formalin-induced paw licking test, EETI at the doses of 200 and 400 mg/kg BW showed highly significant inhibition of writhing in both neurogenic and inflammatory phases. While EETI also exhibited highly significant, compared to control, writhing inhibition for both the doses in acetic acid-induced writhing test. Moderate antiinflammatory effect at a dose of 400 mg/kg BW was noticed in paw-edema test. It also showed 77.51% of maximum antipyretic effect which was significantly effective compared to standard drug paracetamol (150 mg/kg) in Brewer's yeast-induced pyrexia test. The EETI showed potential cytotoxic activity with LC 50 value of 114.46 μg/mL. The PASS prediction revealed the potential antinociceptive and antineoplastic activity of target compounds. The compounds betulinic acid, quercetin-3-α-arabinoside, catsanogenin were found to be effective in molecular docking study. Conclusion: It is evident that the EETI possesses highly significant analgesic activity with remarkable anti-inflammatory and antipyretic activity. The phytoconstituents have potential antinociceptive and antineoplastic (breast cancer) activity.

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In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

Cited by 11 publications

References 16 publications

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review

In vivo and in vitro pharmacological activities of Tacca integrifolia rhizome and investigation of possible lead compounds against breast cancer through in silico approaches

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