In vivo analysis of IgE autoantibodies in bullous pemphigoid: A study of 100 cases

Moriuchi, Reine; Nishie, Wataru; Ujiie, Hideyuki; Natsuga, Ken; Shimizu, Hiroshi

doi:10.1016/j.jdermsci.2015.01.013

Cited by 60 publications

(57 citation statements)

References 22 publications

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“…The vast majority of patients have autoantibodies against epitopes on the extracellular noncollagenous 16A (NC16A) domain of Col-17 [174]. A subgroup of patients suffer from chronic pruritus and develop urticarial plaques, anti-Col-17 IgE autoantibodies, elevated IgE levels, and lesional eosinophilic infiltrates [175, 176]. Patients’ autoantibodies do not bind mouse Col-17 due to cross-species differences in Col-17 sequence; however, passive transfer of rabbit anti-mouse BP180 Ig induces BP-like skin lesions in wildtype mice [177], and patients’ IgG autoantibodies induce blisters in Col-17-humanized mice [178], confirming a critical role for autoantibodies in pathogenesis.…”

Section: Autoimmune Dermatosesmentioning

confidence: 99%

Basement membranes and autoimmune diseases

Foster

2017

Matrix Biology

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Basement membrane components are targets of autoimmune attack in diverse diseases that destroy kidneys, lungs, skin, mucous membranes, joints, and other organs in man. Epitopes on collagen and laminin, in particular, are targeted by autoantibodies and T cells in anti-glomerular basement membrane glomerulonephritis, Goodpasture’s disease, rheumatoid arthritis, post-lung transplant bronchiolitis obliterans syndrome, and multiple autoimmune dermatoses. This review examines major diseases linked to basement membrane autoreactivity, with a focus on investigations in patients and animal models that advance our understanding of disease pathogenesis. Autoimmunity to glomerular basement membrane type IV is discussed in depth as a prototypic organ-specific autoimmune disease yielding novel insights into the complexity of anti-basement membrane immunity and the roles of genetic and environmental susceptibility.

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Section: Autoimmune Dermatosesmentioning

confidence: 99%

Basement membranes and autoimmune diseases

Foster

2017

Matrix Biology

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“…Immunoglobulin E autoantibodies to the BMZ may be detected by direct or indirect fluorescent antibody test . It has been reported that serum IgE autoantibody titer correlates with the extent of the wheals or erythema of BP, and its involvement in the pathology of the condition has been suggested …”

Section: Overview Of Pemphigoid Diseasesmentioning

confidence: 99%

Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita)

Ujiie

Iwata

Yamagami

et al. 2019

The Journal of Dermatology

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The pemphigoid group is a category of autoimmune subepidermal blistering diseases in which autoantibodies deposit linearly at the epidermal basement membrane zone (BMZ). The main subtypes of pemphigoid mediated by immunoglobulin G autoantibodies are bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA). To establish the first guidelines approved by the Japanese Dermatological Association for the management of pemphigoid diseases, the Committee for Guidelines for the Management of Pemphigoid Diseases (Including EBA) was founded as part of the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labor and Welfare Research Project on Overcoming Intractable Diseases. These guidelines aim to provide current information for the management of BP, MMP and EBA in Japan. Based on evidence, the guidelines summarize the clinical and immunological manifestations, pathophysiologies, diagnostic criteria, disease severity determination criteria, treatment algorithms and treatment recommendations. Because of the rarity of these diseases, there are few clinical studies with a high degree of evidence, so several parts of these guidelines were established based on the opinions of the Committee. To further optimize these guidelines, periodic revision in line with the new evidence is necessary.

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“…IgE deposition in the BMZ in patients with BP has frequently been observed 73, 74 , and a correlation between serum levels of IgE autoantibodies against COL17 and BP disease activity has been reported 75 . High-affinity IgE receptor (FcεRI)-bound IgE on mast cells and eosinophils may be involved in the degranulation of such cells following their capture of shed extracellular fragments of COL17, in turn resulting in the development of urticarial erythema in BP 76 .…”

Section: Pemphigoidmentioning

confidence: 99%

Recent advances in the understanding and treatment of pemphigus and pemphigoid

Yamagami¹

2018

F1000Res

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Pemphigus and pemphigoid are characterized as autoimmune blistering diseases in which immunoglobulin G autoantibodies cause blisters and erosions of the skin or mucosa or both. Recently, understanding of the pathophysiology of pemphigus and pemphigoid has been furthered by genetic analyses, characterization of autoantibodies and autoreactive B cells, and elucidation of cell–cell adhesion between keratinocytes. For the management of pemphigus and pemphigoid, the administration of systemic corticosteroids still represents the standard treatment strategy; however, evidence of the efficacy of therapies not involving corticosteroids, such as those employing anti-CD20 antibodies, is increasing. The goal should be to develop antigen-specific immune suppression-based treatments.

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In vivo analysis of IgE autoantibodies in bullous pemphigoid: A study of 100 cases

Cited by 60 publications

References 22 publications

Basement membranes and autoimmune diseases

Basement membranes and autoimmune diseases

Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita)

Recent advances in the understanding and treatment of pemphigus and pemphigoid

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