In vivo and in simulated body fluid degradation behavior and biocompatibility evaluation of anodic oxidation-silane-chitosan-coated Mg-4.0Zn-0.8Sr alloy for bone application

Bahatibieke, Abudureheman; H, Qin; Cui, Tong; Liu, Yan; Wang, Zixuan

doi:10.1016/j.msec.2020.111771

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…According to Figure 7 [76], the shape of the platelet on the surface of CS-coated, and bare Mg alloy is roughly spherical, the pseudopodia is not clear, and the level of platelet activation is poor. However, AO and SA-coated specimens presented a high level of platelet activation with obvious pseudopodia shape [76].…”

Section: Chitosan (Cs) Coated On Mg-based Alloymentioning

confidence: 93%

“…Likewise, Calado et al [75] created a CeO 2 -doped siloxane-based coating, and the results showed that CeO 2 nanofillers inhibited corrosion growth and improved the coating's corrosion resistance for a long period. Bahatibieke et al [76] evaluated the degradation rate and cytocompatibility of anodic oxidation-silane-chitosan coated on Mg-4.0Zn-0.8Sr alloy for bone tissue engineering. According to their findings, the anodizing (AO)-silane (SA)-CS coating sample has a lower corrosion rate as well as good biological properties, such as normal platelet adhesion morphology and a lower hemolysis rate.…”

Section: Chitosan (Cs) Coated On Mg-based Alloymentioning

confidence: 99%

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A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

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Section: Chitosan (Cs) Coated On Mg-based Alloymentioning

confidence: 93%

Section: Chitosan (Cs) Coated On Mg-based Alloymentioning

confidence: 99%

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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“…Consequently, Mg–Gd alloys shows better long-term degradation performance compared to anodized AZ31 Mg alloy. Since, anodic oxidation coatings singularly cannot full fill diverse clinical demands several studies reported their combination with chemical conversion [ 174 , 175 ], electrodeposition [ 176 ], LDHs [ 177 ], sol-gel [ 178 ] coating techniques. These coatings exhibit promising improvement in corrosion resistance and bioactivity of Mg alloys.…”

Section: Coatings and Their Current Statusmentioning

confidence: 99%

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Singh

Batra

Kumar

et al. 2023

Bioactive Materials

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“…Although Mgbased materials have favourable mechanical properties, their degradation is significantly concerned with actual physiological conditions [6]. This results in the loss of its mechanical integrity before the healing time, and the hydrogen evolution leads to an increase in the pH of the body fluids, thereby hindering the growth of bones and tissues [7]. Therefore, researchers investigated controlling the degradation behaviour of Mg by alloying elements, heat treatments and surface treatments [8,9].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of properties of the biocompatible thin films on biodegradable Mg alloys

Rajan¹,

Arockiarajan²

2022

Biomed. Mater.

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Magnesium (Mg) and its alloys have attracted attention as biodegradable material for biomedical applications owing to their favourable biomedical properties. The mechanical properties of Mg alloys are comparable to those of bone, and they are biocompatible. Mg is a factor in many enzymes that are essential for human metabolism and is vital trace element for human enzymes. Before biomedical applications, the early stage or fast degradation of Mg and its alloys in the physiological environment should be controlled. The degradation of Mg alloys is a critical criterion that can be controlled by a surface modification which is an effective process for conserving their desired properties. Different coating methods have been employed to modify Mg surfaces to provide good corrosion resistance and biocompatibility. This review aims to provide information on different coatings and discuss their physical and biological properties. Finally, challenges are proposed, and future perspectives are discussed.

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In vivo and in simulated body fluid degradation behavior and biocompatibility evaluation of anodic oxidation-silane-chitosan-coated Mg-4.0Zn-0.8Sr alloy for bone application

Cited by 12 publications

References 34 publications

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

A comprehensive review of properties of the biocompatible thin films on biodegradable Mg alloys

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