In vivo and in vitro studies on the effect of the serotorinergic system on luteinizing hormone and luteinizing hormone-releasing hormone secretion in prepubertal and peripubertal female rats

Arias, Pablo; Szwarcfarb, Berta; Rondina, Dora; Carbone, Silvia; Sverdlik, Rita C.; Moguilevsky, Jaime A.

doi:10.1016/0006-8993(90)91634-s

Cited by 34 publications

(12 citation statements)

References 22 publications

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“…The stimulatory effect of 5-HTP on LH secretion in prepubertal female rats is exerted at the hypothalamic level since the perifusion of hypothalamic areas with 5-HTP increased GnRH release when taken from 16 day old rats but not from 30 day old animals; at this age, 5-HTP has an inhibitory effect on GnRH release (Arias et al, 1990;Arias et al, 1992).…”

Section: Effect Of the Serotoninergic Systemmentioning

confidence: 99%

Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats

Moguilevsky¹,

Wuttke²

2001

Exp Clin Endocrinol Diabetes

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Gonadotrophin hormone releasing hormone (GnRH) is the primary messenger involved in sexual maturation and the onset of puberty. The activity of these neurons are controlled by several neurotransmitters systems. The onset of puberty implies changes from a prepubertal type of gonadotrophin secretion, characterized by a low activity of GnRH neurons, to an adult pattern of secretion with phasic and synchronous activation of GnRH neurons resulting in an increase in the amplitute and frequency of GnRH pulses. Neurotransmitter systems are involved in these changes of GnRH secretion during the onset of puberty by quantitative and qualitative modifications in the effect on GnRH secretion. Serotonin (5-HT), GABA and catecholamines (CA) have qualitative differences in the effects on GnRH and LH secretion in early prepubertal than in late prepubertal and adult female rats. The administration of 5-hydroxytryptophan a precursor of serotonin (5-HT) which increases 5-HT hypothalamic levels induces GnRH and LH release in early prepubertal female rats, these effects dissapear in late prepubertal stage having an inhibitory action in adult female rats. GABAergic system also stimulates GnRH and LH secretion in early prepubertal female rats and has an inhibitory action on this axis in late prepubertal period and in adult female rats. On the contrary the inhibition of catecholamines synthesis by alpha-methyl-p-tyrosine induced an increase of LH secretion in early prepubertal female rats and inhibitory effect in late prepubertal and adult stage. These effects indicate tha CA has an inhibitory effects on GnRH-LH secretion in early prepubertal female rats changing to an stimulatory action in the late puberty and adult rats. These qualitative modifications were observed only in female rats and are probably connected with the hypothalamic differentiation into a female type of gonadotrophin control. Opiadergic and excitatory amino acid systems have quantitative differences on GnRH-LH secretion during prepubertal and peripubertal and adult stages. Opiates has an high inhibitory tone in early prepubertal rats that is decreasing during sexual maturation to reach puberty. On the contrary EAA increases its stimulatory activity on GnRH-LH secretion during sexual maturation by increasing the hypothalamic release of aspartate and glutamate, the excitatory amino acids involved in GnRH release, and the sensibility of NMDA receptors to these amino acids. In conclusion sexual maturation and the onset of puberty in the female rats involve qualitative and quantitative modifications in the effects of neurotrasmitters system on GnRH secretion.

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Section: Effect Of the Serotoninergic Systemmentioning

confidence: 99%

Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats

Moguilevsky¹,

Wuttke²

2001

Exp Clin Endocrinol Diabetes

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“…Superfusion experiments were performed as described previously [20]. Briefly, the animals were decapitated at noon, the brain was removed rapidly and placed on ice.…”

Section: Methodsmentioning

confidence: 99%

Interleukin-1 Inhibits NMDA-Stimulated GnRH Secretion: Associated Effects on the Release of Hypothalamic Inhibitory Amino Acid Neurotransmitters

Feleder

Arias

Refojo

et al. 1999

Neuroimmunomodulation

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Immune system activation is often accompanied by alterations in the reproductive axis. Interleukin-1 (IL-1), a polypeptide cytokine, has been postulated as a chemical messenger between the immune and the neuroendocrine systems. Using superfused hypothalamic fragments explanted from intact male rats, we evaluated the effects of IL-1 (0.5 and 5 nM) on basal and N-methyl-D-aspartate (NMDA)-stimulated release of gonadotropin-releasing hormone (GnRH), and the associated modifications in the output of inhibitory amino acid neurotransmitters involved in the control of GnRH secretion. IL-1 did not modify basal GnRH release, but markedly restrained the stimulatory effect of NMDA on GnRH secretion. γ-Aminobutyric acid, glycine and taurine concentrations significantly increased in the superfusion medium only after pretreatment with the higher dose of IL-1 (p < 0.05). Our results indicate that this cytokine inhibits NMDA- stimulated GnRH release, affecting the activity and/or the release of hypothalamic excitatory and inhibitory amino acid neurotransmitters participating in the regulation of GnRH secretion.

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“…Thereby, it is evident the influence of serotoninergic pathways on the HPG axis control during brain development [29,35,45]. Although the estradiol dosage was not conducted in pubertal females in the present study, we suggest that 5-HT delays the estradiol release by ovaries due to its influence on the gonadotropins release and consequently delayed sexual maturity.…”

Section: Tablementioning

confidence: 53%

“…It is known that hypothalamic GnRH-producing neurons receive serotoninergic innervation and this neurotransmitter is found in hypophysis and ovaries [29]. In this way, some studies have evidenced that 5-HT plays an important role in the regulation and control of HPG axis due to its influence on gonadotropin release [35]. Hence, Moran et al observed that 5-HT subcutaneous administration (25 and 37.5 mg/kg) from PND 30 until the VO day in prepubertal rats, delayed VO, first estrus and reduced the estradiol plasmatic levels [29].…”

Section: Tablementioning

confidence: 99%

“…Although there was a delay in puberty onset, all the parameters analyzed in these adult females have not changed. This result may be due to the fact that 5-HT system modulation on gonadotropin secretion is controversial (some studies showed an inhibitory [36,47] or stimulatory pattern [35,47] or even the absence of activity [35,48] and varies with the animal's age-prepubertal [35,39,47], peripubertal [35,48] and adult [35,47].…”

Section: Tablementioning

confidence: 99%

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In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring

Santos

Vieira

Camin

et al. 2016

Reproductive Toxicology

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Depression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5mg/kg or 0.3ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods.

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In vivo and in vitro studies on the effect of the serotorinergic system on luteinizing hormone and luteinizing hormone-releasing hormone secretion in prepubertal and peripubertal female rats

Cited by 34 publications

References 22 publications

Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats

Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats

Interleukin-1 Inhibits NMDA-Stimulated GnRH Secretion: Associated Effects on the Release of Hypothalamic Inhibitory Amino Acid Neurotransmitters

In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring

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