In vivo and in vitro results of an automated preloaded delivery system for IOL implantation in cataract surgery

Mastropasqua, Leonardo; Toto, Lisa; D’Ugo, Erminia; Lanzini, Manuela; Mattei, Peter; Falconio, Gennaro; Doronzo, Emanuele; Diomede, Francesca; Trubiani, Oriana

doi:10.1007/s10792-019-01154-0

Cited by 13 publications

(18 citation statements)

References 16 publications

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“…The roughness average (Ra), that is the arithmetic mean of the absolute values of the height of the surface profile, was assumed for the statistical analysis. Five samples of each group were analyzed, and the mean values (±standard deviation) were considered for statistical analysis (Mastropasqua et al, 2020).…”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

Enhanced VEGF/VEGF-R and RUNX2 Expression in Human Periodontal Ligament Stem Cells Cultured on Sandblasted/Etched Titanium Disk

Marconi

Diomede

Pizzicannella³

et al. 2020

Front. Cell Dev. Biol.

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Bone formation, in skeletal development or in osseointegration processes, is the result of interaction between angiogenesis and osteogenesis. To establish osseointegration, cells must attach to the implant in a direct way without any deposition of soft tissue. Structural design and surface topography of dental implants enhance the cell attachment and can affect the biological response. The aim of the study was to evaluate the cytocompatibility, osteogenic and angiogenic markers involved in bone differentiation of human periodontal ligament stem cells (hPDLSCs) on different titanium disks surfaces. The hPDLSCs were cultured on pure titanium surfaces modified with two different procedures, sandblasted (Control-CTRL) and sandblasted/etched (Test-TEST) as experimental titanium surfaces. After 1 and 8 weeks of culture VEGF, VEGF-R, and RUNX2 expression was evaluated under confocal laser scanning microscopy. To confirm the obtained data, RT-PCR and WB analyses were performed in order to evaluate the best implant surface performance. TEST surfaces compared to CTRL titanium surfaces enhanced cell adhesion and increased VEGF and RUNX2 expression. Moreover, titanium TEST surfaces showed a different topographic morphology that promoted cell adhesion, proliferation, and osteogenic/angiogenic commitment. To conclude, TEST surfaces performed more efficiently than CTRL surfaces; furthermore, TEST surface results showed them to be more biocompatible, better tolerated, and appropriate for allowing hPDLSC growth and proliferation. This fact could also lead to more rapid bone-titanium integration.

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Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

Enhanced VEGF/VEGF-R and RUNX2 Expression in Human Periodontal Ligament Stem Cells Cultured on Sandblasted/Etched Titanium Disk

Marconi

Diomede

Pizzicannella³

et al. 2020

Front. Cell Dev. Biol.

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“…ey also postulated that the difference between the motorized injector and the manual injector is due to a combination of factors, such as the different pressure required to maintain close apposition of the cartridge tip to the wound, discontinuous movement of the IOL through the wound with the manual injector, rotation of the tip around the zaxis of the injector when turning the screw, and yaw (sideto-side movement) in relation to the wound entrance when manipulating the manual injector [6]. Mastropasqua et al [9] demonstrated that the AutonoMe, CO 2 -powerd automated injector, caused less tissue damage to the cornea compared with the Monarch III injector, and this result is probably attributable to a greater amount of corneal stress and trauma at the wound provided by the conventional injector system compared to the automated delivery system. It was postulated that automated delivery system prevents surgeons' inadvertent maneuvers during IOL implantation as it could occur when using manual injectors, and can standardize the injection procedures [9].…”

Section: Discussionmentioning

confidence: 99%

“…Mastropasqua et al [9] demonstrated that the AutonoMe, CO 2 -powerd automated injector, caused less tissue damage to the cornea compared with the Monarch III injector, and this result is probably attributable to a greater amount of corneal stress and trauma at the wound provided by the conventional injector system compared to the automated delivery system. It was postulated that automated delivery system prevents surgeons' inadvertent maneuvers during IOL implantation as it could occur when using manual injectors, and can standardize the injection procedures [9].…”

Section: Discussionmentioning

confidence: 99%

“…When the surgeons lift the lever, the plunger stops advancement immediately. One clinical study [9] reported that this automated preloaded system yields less corneal tissue trauma compared with a manual injector system, and two experimental studies evaluated enlargement of corneal incision associated with the automated preloaded system [10,11]. However, there has been no study on the influence of this new injector system on delivery performance and sclerocorneal wound enlargement.…”

Section: Introductionmentioning

confidence: 99%

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Experimental Study on Delivery Performance of an Automated Preloaded Intraocular Lens Injector System for Corneal and Sclerocorneal Incisions

Oshika

Sasaki

2021

Journal of Ophthalmology

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Purpose. To evaluate delivery performance of an automated preloaded intraocular lens (IOL) injector systems (AutonoMe) in the porcine eyes. Methods. In the freshly excised porcine eyes, lens removal and IOL implantation were performed. There were 4 groups (10 eyes per group) with different incision site and size: 2.2-mm and 2.4-mm corneal incisions and 2.2-mm and 2.4-mm sclerocorneal incisions. Delivery performance and wound enlargement of AutonoMe were analyzed and compared with those of iTec and iSert from a previous study. Results. There were a few minor troubles associated with AutonoMe, such as overriding plunger within cartridge and trapped trailing haptic during IOL insertion, but the incidence was low. Other interactions were not observed, such as IOL adherence to plunger, sudden ejection of IOL, intrawound lens manipulation, IOL behavior, and gross damage to IOL. AutonoMe caused significantly less wound enlargement for both corneal and sclerocorneal incisions than other injector devices. Wound enlargement by using AutonoMe was significantly smaller with 2.4-mm corneal incision than with 2.2-mm corneal incision, but the final incision size was still smaller with 2.2-mm corneal incision. For sclerocorneal incisions, the amount of wound stretch was not different between 2.2 and 2.4 mm incisions. Conclusion. The wound enlargement caused by the automated preloaded insertion system, AutonoMe, was smaller than that of other preloaded injectors for both corneal and sclerocorneal incisions. There were a few minor technical events during IOL insertion, but the overall incidence was low.

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“…Several experimental and clinical studies have reported that the new lens had the lowest levels of surface and bulk inhomogeneities and optical characteristics including surface light scattering, glistenings, and chromatic aberration compared to the commercially available IOLs, those resulted in good clinical outcomes [1][2][3][4][5][6][7][8][9][10]. Several previous reports have evaluated the clinical results of the Clareon IOL with the AutonoMe 1 automated delivery system [2,11]; however, no reports have described the early postoperative refractive stability or the postoperative wound-repair process. The current study reports the refractive stability in the early postoperative period and the wound repair process after cataract surgery with the Clareon IOL and the AutonoMe automated delivery system.…”

Section: Introductionmentioning

confidence: 99%

Refractive stability of a new single-piece hydrophobic acrylic intraocular lens and corneal wound repair after implantation using a new automated intraocular lens delivery system

et al. 2020

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To investigate refractive stability and characterize corneal incision repair up to 3 months after implantation of a new hydrophobic acrylic intraocular lens (IOL) with hydroxyethylmethacrylate using a new automated IOL delivery system. Methods This prospective case series included 50 eyes of 50 patients undergoing phacoemulsification and implantation of the Clareon ® CNA0T0 IOL using the AutonoMe ® automated delivery system in the Department of Ophthalmology, Keio University School of Medicine. The clinical data were collected from 46 eyes of 46 patients preoperatively and 1 day, 1 week, and 1 and 3 months postoperatively. Endothelial-side incision gaping, posterior incision retraction, and Descemet's membrane detachment were recorded as present or absent using anteriorsegment optical coherence tomography postoperatively. Results The uncorrected distance and corrected distance visual acuities improved and stabilized 1 week postoperatively. The anterior chamber depth was stable from 1 week postoperatively. The subjective refraction was stable from 1 day postoperatively. Descemet's membrane detachments and endothelial-side wound gaping were seen in 19 (41.3%) eyes and 34 (73.9%) eyes 1 day postoperatively and decreased gradually. Posterior incision retraction was seen in eight eyes (17.4%) on day 1 and increased to 19 eyes (41.3%) 3 months postoperatively.

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In vivo and in vitro results of an automated preloaded delivery system for IOL implantation in cataract surgery

Cited by 13 publications

References 16 publications

Enhanced VEGF/VEGF-R and RUNX2 Expression in Human Periodontal Ligament Stem Cells Cultured on Sandblasted/Etched Titanium Disk

Enhanced VEGF/VEGF-R and RUNX2 Expression in Human Periodontal Ligament Stem Cells Cultured on Sandblasted/Etched Titanium Disk

Experimental Study on Delivery Performance of an Automated Preloaded Intraocular Lens Injector System for Corneal and Sclerocorneal Incisions

Refractive stability of a new single-piece hydrophobic acrylic intraocular lens and corneal wound repair after implantation using a new automated intraocular lens delivery system

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