"In vivo" and "in vitro" antimicrobial activity of Origanum vulgare essential oil and its two phenolic compounds on clinical isolates of Candida spp.

Stringaro, Annarita; Colone, Marisa; Cecchetti, Serena; Zeppetella, Elisa; Spadaro, Francesca; Angiolella, Letizia

doi:10.1007/s00203-022-03355-1

Cited by 5 publications

(4 citation statements)

References 54 publications

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“…The results obtained showed that C. albicans and C. glabrata were more virulent, while C. krusei isolates were avirulent. The virulence of C. parapsilosis was an identified variable, and similar results were also observed in C. albicans, C. tropicalis, C. glabrata and C. krusei [68].…”

Section: Candida Sppsupporting

confidence: 72%

“…G. mellonella has been used to study many fungi, including Aspergillus spp., Candida spp., Cryptococcus spp., Conidiobolus coronatus , Histoplasma capsulatum , Madurella mycetomatis , Malassezia spp. and Paraccocidioides brasiliensis [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ].…”

Section: G Mellonella As a Model To Study Fungi In Vivomentioning

confidence: 99%

“…Categorising studies using G. mellonella larvae to assess virulence or drug efficacy is a challenging task. It is more appropriate to evaluate the work based on different fungal genera since some species have undergone extensive research in recent years [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ].…”

Section: G Mellonella As a Model To Study Fungi In Vivomentioning

confidence: 99%

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Galleria mellonella as a Model for the Study of Fungal Pathogens: Advantages and Disadvantages

Giammarino,

Bellucci,

Angiolella

2024

Pathogens

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The study of pathogenicity and virulence of fungal strains, in vivo in the preclinical phase, is carried out through the use of animal models belonging to various classes of mammals (rodents, leproids, etc.). Although animals are functionally more similar to humans, these studies have some limitations in terms of ethics (animal suffering), user-friendliness, cost-effectiveness, timing (physiological response time) and logistics (need for adequately equipped laboratories). A good in vivo model must possess some optimal characteristics to be used, such as rapid growth, small size and short life cycle. For this reason, insects, such as Galleria mellonella (Lepidoptera), Drosophila melanogaster (Diptera) and Bombyx mori (Lepidoptera), have been widely used as alternative non-mammalian models. Due to their simplicity of use and low cost, the larvae of G. mellonella represent an optimal model above all to evaluate the virulence of fungal pathogens and the use of antifungal treatments (either single or in combination with biologically active compounds). A further advantage is also represented by their simple neuronal system limiting the suffering of the animal itself, their ability to survive at near-body ambient temperatures as well as the expression of proteins able to recognise combined pathogens following the three R principles (replacement, refinement and reduction). This review aims to assess the validity as well as the advantages and disadvantages of replacing mammalian classes with G. mellonella as an in vivo study model for preclinical experimentation.

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Section: Candida Sppsupporting

confidence: 72%

Section: G Mellonella As a Model To Study Fungi In Vivomentioning

confidence: 99%

Section: G Mellonella As a Model To Study Fungi In Vivomentioning

confidence: 99%

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Galleria mellonella as a Model for the Study of Fungal Pathogens: Advantages and Disadvantages

Giammarino,

Bellucci,

Angiolella

2024

Pathogens

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“…In contrast, C. albicans displayed susceptibility to fluconazole, with MIC values of 0.5 μg/mL. The MFC for fluconazole in all tested strains fell within 64 to >128 μg/mL [41].…”

Section: Antimicrobial Activitymentioning

confidence: 83%

Composition, Bioactivities, Safety Concerns, and Impact of Essential Oil on Pets’ and Animals’ Health

Sisubalan,

Sivamaruthi,

Kesika

et al. 2023

Preprint

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Essential oils (EOs) are highly concentrated and volatile blends of nonpolar substances, are derived from aromatic plant components and comprise terpenes, terpenoids and phenylpropanoids, exhibiting diverse biological and pharmacological properties. The burgeoning pet industry is interested in EOs as a potential solution for common health issues in domestic animals, particularly in addressing antimicrobial resistance. The present study summarizes the composition, properties, benefits, safety considerations, and effects of EOs on pets and animals. The applications of EOs range from antimicrobial effects to antioxidant, anti-inflammatory, and anticancer activities etc. Furthermore, EOs are used extensively in various industries, including beauty care products, detergents, and fragrances. The chemical constituents of EOs, exemplified by eucalyptus EO and rosemary EO, highlight their distinct aromatic profiles and potential benefits. Nevertheless, understanding the chemical makeup of EOs is fundamental in assessing their potential impacts on biological systems. Safety considerations, including potential toxicity, are essential when incorporating EOs into animal care routines. The feed additives incorporating EOs have shown promise in influencing gut microbiota balance, reducing inflammation, and acting as antioxidants. However, cautious application is paramount, considering the potential risks associated with high doses or multiple administrations. Preliminary studies suggest low toxicity levels, but further research is required to evaluate the safety of EOs. Though studies reported the beneficial effects of EOs on pets and animals, further research is needed to validate the findings in real-world conditions. The paper also discussed the regulatory considerations and future perspectives on applying EOs in veterinary medicine.

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Essential oil of oregano (Origanum vulgare L.) reduces infection and proliferation of Toxoplasma gondii in BeWo cells with induction of autophagy and death of tachyzoites through a mechanism similar to necrosis

Nunes,

dos Santos,

da Silva Sanfelice

et al. 2024

Parasitol Res

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"In vivo" and "in vitro" antimicrobial activity of Origanum vulgare essential oil and its two phenolic compounds on clinical isolates of Candida spp.

Cited by 5 publications

References 54 publications

Galleria mellonella as a Model for the Study of Fungal Pathogens: Advantages and Disadvantages

Galleria mellonella as a Model for the Study of Fungal Pathogens: Advantages and Disadvantages

Composition, Bioactivities, Safety Concerns, and Impact of Essential Oil on Pets’ and Animals’ Health

Essential oil of oregano (Origanum vulgare L.) reduces infection and proliferation of Toxoplasma gondii in BeWo cells with induction of autophagy and death of tachyzoites through a mechanism similar to necrosis

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