In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Deschamps, A.A.; Apeldoorn, Aart van; Hayen, Heiko; Bruijn, Joost D. de; Kärst, Uwe; Grijpma, Dirk W.; Feijén, Jan

doi:10.1016/s0142-9612(03)00495-2

Cited by 83 publications

(84 citation statements)

References 42 publications

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“…A significant amount of work on degradable polymer scaffolds for internal fixation devices or tissue engineering has been published over the last few years, [22][23][24][25] mostly centered on the use of poly(a-hydroxy esters). The composites used in this work were prepared using a polymer derived from a methacrylate-modified oligolactide.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide‐containing polymer networks

Brauer¹,

Rüssel²,

Vogt³

et al. 2006

J Biomedical Materials Res

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Degradable porous composite materials for use as temporary bone replacement or tissue engineering scaffolds were produced using a methacrylate-modified oligolactide polymer network and phosphate invert glasses in the system P2O5-CaO-MgO-Na2O-(TiO2). Porous glasses with an open interconnective porosity were produced by a salt sintering process. Compressive strengths were significantly enhanced by polymer coating of the inner surface of the porous glasses or by fabrication of glass powder-reinforced porous polymer specimens. In vitro degradation in simulated body fluid showed a degradation pattern of the composites which could be modulated by the composition and resulting solubility of the incorporated glass phase. Cytocompatibility of the composites was investigated in a FDA/EtBr viability assay using an MC3T3-E1 osteoblast-like cell line and showed good biocompatibility of the materials in vitro.

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Section: Discussionmentioning

confidence: 99%

Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide‐containing polymer networks

Brauer¹,

Rüssel²,

Vogt³

et al. 2006

J Biomedical Materials Res

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“…Additionally, it has been demonstrated that closed -cell foams of these materials can be obtained using CO 2 as a blowing agent [73] . Poly(ether ester amide) ( PEEA ) copolymers based on PEG, 1,4 -butanediol, and dimethyl -7,12 -diaza -6,13 -dione -1,18 -octadecanedioate [74] ( Figure 6.4 b) have also been evaluated as scaffold materials for tissue engineering and have proved to sustain adhesion and growth of endothelial cells.…”

Section: Aliphatic Poly(ester Amide)s: a Family Of Biodegradable Thermentioning

confidence: 99%

Biodegradable Polyurethanes and Poly(ester amide)s

Rodríguez‐Galán

Franco

Puiggalı́

2011

Handbook of Biodegradable Polymers

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AbbreviationsBDI 1,4 -buthylenediisocyanate BDO 1,4 -butanediol DSC differential scanning calorimetry DMSO dimethyl sulfoxide DMPA dimethylol propionic acid DUD diurethanediol DMTA dynamic mechanical thermal analysis EM electron microscopy ED ethylene diamine H12MDI dicyclohexylmethane diisocyanate HS hard segment HDI 1,6 -hexamethylene diisocyanate IR infrared spectroscopy IPDI isophorone diisocyanate LDI lysin methyl ester diisocyanate MDI diphenylmethane diisocyanate NMR nuclear magnetic resonance PCL polycaprolactone PCUs polycarbonate -based polyurethanes PDA propanediamine PDMO poly(decamethylene glycol) PEAs poly(ester amide)s PEEA poly(ether ester amide) PEO poly(ethylene glycol) PEUs polyester -based polyurethanes PHMO poly(hexamethylene glycol) POMO poly(octamethylene glycol) PTMO polytetramethylene oxide glycol PURs polyurethanes SAXS small -angle X -ray scattering

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“…[21] Since PED materials based on PBT exhibit apatite layer formation on their surfaces after immersion in SBF, [12] we were interested in investigating nanocrystalline HAp-filled materials, containing poly(ethylene glycol) (PEG) as a strongly hydrophilic segment, in a polymer matrix commonly used in biodegradable drug-delivery systems or scaffolds for tissue engineering. [22,23] It was postulated that introducing HAp into such poly(ester-ether-ester) terpolymer structure should provide better bone remodeling for bone-contacting PEDbased biomaterials.…”

Section: By Miroslawa El Fray*mentioning

confidence: 99%

Polymer Matrix Nanocomposites from Biodegradable Thermoplastic Elastomers

Fray

2009

Adv Eng Mater

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The development of biodegradable thermoplastic elastomers (TPEs) has recently become an emerging problem in the search for new materials with specific proprieties. Although they are macroscopically homogeneous, TPEs phase-separate at a microscopic (nanometer) scale. Discrete plastic phases are embedded in the continuous elastomer phase and form physical cross-links. Hence, TPEs behave like cured rubbers at room temperature and can be processed as plastics at higher temperatures. The development of new biomaterials for specific applications (e.g. flexible finger joints, elastomeric patches) requires different systems with an interesting combination of specific physico-chemical, mechanical, and processing properties as well as degradability. [1][2][3] Poly(aliphatic/aromatic ester)s (PEDs) are new TPE materials that have recently attracted attention for biomedical applications. [4,5] They can be composed of semicrystalline poly(ethylene terephthalate) (PET) or poly(butylene terephthalate) (PBT) hard segments and amorphous fatty acid (e.g. dimerized linoleic acid (DLA)) sequences as soft segment components. Commercially available dimerized fatty acids containing C 36 chains are the polymerization products of C 18 unsaturated fatty acids or esters such as linoleic and oleic acids derived from vegetable oils. [6,7] PEDs are synthesized with the use of monomers from renewable resources (DLA) and, most importantly, without thermal stabilizers, which might be irritants when washed out from the polymers in the human body environment. As well as exhibiting biocompatibility in vitro and in vivo, PED polymers showed excellent mechanical properties, especially fatigue resistance, in previous investigations for soft-tissue reconstruction (finger flexor tendon reconstruction). [8][9][10] Since PEDs are categorized as thermoplastic elastomers, they can be tailor-made: at low concentration of the hard phase these materials have stress-strain curves typical of elastomers, whereas increasing concentration of the hard phase results in a higher toughness typical of thermoplastics. Simultaneously, PED materials showed slow degradation in vivo (over 40% decrease of molecular weight after 6 months implantation) owing to presence of highly hydrophobic dimerized fatty acid. [11] An interesting observation was made while investigating the mechanical properties of PBT-based PED copolymers in simulated body fluid (SBF). [12] Polymers showed improved mechanical properties relative to the untreated material because of the formation of hydroxyapatite (HAp) layer on the surface of the polymer. The crystal formation on the polymer surface can have a reinforcing effect, providing improved static and dynamic mechanical properties. [12] It is well-known [13] that material reinforcement resulting in improved mechanical strength can be realized by preparing composites using different fillers, such as bioactive ceramics [13] or carbon nanotubes [14] or nanoparticles. [15] In the case of addition of nanoparticles, it was demonstrated that a small amount...

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In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Cited by 83 publications

References 42 publications

Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide‐containing polymer networks

Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide‐containing polymer networks

Biodegradable Polyurethanes and Poly(ester amide)s

Polymer Matrix Nanocomposites from Biodegradable Thermoplastic Elastomers

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