In vivo and in vitro antioxidant properties of furosemide

Lahet, Jean-Jacques; Lenfant, F.; Courderot-Masuyer, C.; Ecarnot-Laubriet, E.; Vergely, Catherine; Durnet-Archeray, M.-J.; Freysz, M.; Rochette, Luc

doi:10.1016/s0024-3205(03)00382-5

Cited by 23 publications

(18 citation statements)

References 25 publications

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“…Our study showed that CO-RM2 and Trolox are potent peroxyl radical scavengers in vitro. These in vitro experiments with AAPH, though not clinically relevant, may help to understand the specific role played by antioxidants [28,29]. An important point in our results is that we found a considerable loss of the antioxidant properties of CO-RM2 with time, underlining the role of CO in this protective effect.…”

Section: Discussionmentioning

confidence: 61%

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Berne¹,

Lauzier²,

Rochette³

et al. 2012

Cell Physiol Biochem

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Carbon monoxide (CO) is believed to mediate many of the cytoprotective effects attributed to the activation of heme oxygenase (HO-1), the enzyme responsible for CO production. Recently, the study of CO-releasing molecules (CO-RMs) has provided a new approach for the delivery of CO. In the present study, we examined whether the cardioprotective properties of CO-RM2 in isolated rat hearts subjected to an ischemia-reperfusion (I/R) sequence were associated with the presence of CO. In addition, the antioxidant properties of CO-RM2 were evaluated. In hearts pretreated with CO-RM2, the improvement in contractile function at the end of the reperfusion period after 20 min of global total ischemia was significantly greater than in controls. These beneficial effects were accompanied by a reduction in 1) LDH activity release 2) infarct size 3) ventricular superoxide production. The improvement in myocardial function and the reduction in oxidative stress were not observed when hearts were pretreated with inactivated CO-RM2 (iCO-RM2). Additionally, CO-RM2, but not iCO-RM2, was found to exert antioxidant properties. These results suggest that the production of CO is a necessary factor in the cardioprotective and antioxidant actions of CO-releasing compound. These results may open up new ground for a novel class of cardioprotective compounds.

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Section: Discussionmentioning

confidence: 61%

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Berne¹,

Lauzier²,

Rochette³

et al. 2012

Cell Physiol Biochem

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“…Furosemide could enhance its acute antidepressant-like actions by enhancing cAMP-CREB-BDNF signaling. It could enhance this downstream signalling by its effect on angiotensin (Charron et al, 2002), its anti-oxidant effects (Lahet et al, 2003), its effect on adenosine (O`Connor et a., 1991), phosphodiesterase (Marcus et al, 1978) and cytokines (Yuengsrigul et al, 1999). Its effect in down-regulating the dopamine transporter (Lucas et al, 2007) and norepinephrine transporter (Habecker et al, 2003) could also enhance cAMP-CREB-BDNF signalling.…”

Section: Discussionmentioning

confidence: 99%

“…In the peripheral nervous system, the actions of furosemide may overlap with that of cAMP (Kreydiyyeh et al, 2000). Furosemide's anti-oxidant actions (Lahet et al, 2003), its effect on cytokines (Yuengsrigul et al, 1999) and its attenuation of glutamate-mediated excitotoxicity (Sanchez-Gomez et al, 2011) enhances neuroplasticity. Its upregulation of brainderived neurotrophic factor (BDNF) (Szekeres et al, 2010) which is deficient in depression, its enhancement of long-term potentiation (LTP) and neurogenesis being a KCC 2 blocker (Wang et al, 2006;Roitman et al, 2002) and favourable effects on Bcl-2/Bax ratio being a Bax blocker (Lin et al, 2005) enhances the neurotrophic signaling cascade of brain derived neurotrophic factorearly signal regulated kinase-cAMP-response element binding protein-B cell lymphoma 2 (BDNF-ERK 1/2-CREB-Bcl-2), an important mediator of neuroplasticity, which is impaired by stress (Trentani et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

S.¹,

E.²

2012

Afr. J. Biotechnol.

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“…60 Furosemide has also been shown to act as a dose-dependent antioxidant. 6,61,62 Using a well-established pig model with survival to 24 h as the primary outcome measure, furosemide was administered at a dose of 40 mg by nebulizer 1, 3,5,7,9,12,16, and 20 h postexposure to phosgene. There were eight animals in each of the treatment and control groups.…”

Section: Furosemidementioning

confidence: 99%