In vivo and in vitro analysis of cytogenotoxicity in populations living in abnormal conditions from Santos-Sao Vicente estuary

Alpire, Maria Esther Suarez; Camargo, Elaine Aparecida de; Cardoso, Caroline Margonato; Salvadori, Daisy Maria Fávero; Pereira, Camilo Dias Seabra; Ribeiro, Daniel Araki

doi:10.1007/s11356-020-07602-0

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…6 Recently, several research groups have successfully applied the assay to populations (adults and children) exposed to several environmental agents, such as drugs, dental radiographs, and chemicals. [7][8][9] Intraoral fixed orthodontic appliances comprise brackets, bands, archwires, and cements made of alloys and containing different concentrations of cobalt, chromium, and nickel. Currently, dentistry offers a wide range of orthodontic brackets, which are associated with a growing number of protocols for orthodontic therapy (OT).…”

Section: Introductionmentioning

confidence: 99%

The use of micronucleus assay in exfoliated oral cells in patients undergoing fixed orthodontic therapy: a systematic review with meta-analysis

SOUZA,

TAKESHITA,

CASTRO

et al. 2023

Braz. oral res.

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The aim of this systematic review was to evaluate published papers regarding the micronucleus assay in oral mucosal cells of patients undergoing orthodontic therapy (OT). A search of the scientific literature was made in the PubMed, Scopus, and Web of Science databases for all data published until November, 2021 using the combination of the following keywords: "fixed orthodontic therapy," "genetic damage", "DNA damage," "genotoxicity", "mutagenicity", "buccal cells", "oral mucosa cells," and "micronucleus assay". The systematic review was designed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Nine studies were retrieved. Some authors demonstrated that OT induces cytogenetic damage in oral mucosal cells. Out of the nine studies included, two were classified as strong, five as moderate, and two as weak, according to the quality assessment components of the Effective Public Health Practice Project (EPHPP). Meta-analysis data revealed no relationship between mutagenicity in oral cells and OT in different months of treatment. At one month, the SMD = 0.65 and p = 0.08; after three months of OT, the SMD = 1.21 and p = 0.07; and after six months of OT, the SMD = 0.56 and p = 0.11. In the analyzed months of OT, I 2 values were >75%, indicating high heterogeneity. In summary, this review was not able to demonstrate that OT induces genetic damage in oral cells. The study is important for the protection of patients undergoing fixed OT, given that mutagenesis participates in the multi-step process of carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

The use of micronucleus assay in exfoliated oral cells in patients undergoing fixed orthodontic therapy: a systematic review with meta-analysis

SOUZA,

TAKESHITA,

CASTRO

et al. 2023

Braz. oral res.

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“…It is widely accepted that an increased frequency of micronuclei in oral exfoliated cells is useful for identifying the presence of several carcinogens in the environment (9). In fact, several authors have used the micronucleus assay to investigate genetic damage in individuals (adults and children) exposed to environmental conditions, such as dental radiographs, drugs, and chemical compounds (10)(11)(12).…”

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confidence: 99%

Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With Meta-analysis

et al. 2021

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Aim: The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. Materials and Methods: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: "panoramic X-ray," "DNA damage," "genetic damage", "genotoxicity", "mutagenicity", cytotoxicity", "buccal cells", "oral mucosa", "tongue", "gingiva", "micronucleus assay", according to the PRISMA guidelines. All clinical studies in English language were included in the study. A total of 10 studies were identified. Results: As expected, the results regarding the cytogenetic damage induced by panoramic X-ray are conflicting. Some authors have demonstrated that panoramic X-ray induces mutagenesis in oral cells, whereas others did not. After reviewing the 10 studies, two were classified as strong, four were considered moderate, and four were considered weak, according to the quality assessment components of the Effective Public Health Practice Project (EPHPP). Meta-analysis data revealed a negative response related to mutagenicity in oral cells by panoramic X-ray. Conclusion: Taken together, this review failed to demonstrate the association between micronucleus frequency and panoramic X-ray.

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Genotoxicity of surface waters in Brazil

Soldi

Londero

Schavinski

et al. 2023

Mutation Research/Genetic Toxicology and Environmental Mutagene

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In vivo and in vitro analysis of cytogenotoxicity in populations living in abnormal conditions from Santos-Sao Vicente estuary

Cited by 4 publications

References 33 publications

The use of micronucleus assay in exfoliated oral cells in patients undergoing fixed orthodontic therapy: a systematic review with meta-analysis

The use of micronucleus assay in exfoliated oral cells in patients undergoing fixed orthodontic therapy: a systematic review with meta-analysis

Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With Meta-analysis

Genotoxicity of surface waters in Brazil

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