In vivo and In vitro anti-diabetic effects of cinnamon (Cinnamomum sp.) plant extract: A review

Nazareno, Alyssa MA; Purnamasari, Listya; Cruz, Joseph F dela

doi:10.20956/canrea.v5i2.673

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Dietary interventions derived from natural resources have been identified as having the potential to control sugar levels in people with diabetes. Herbal plants can be utilized to synthesize drugs to treat diabetes mellitus (13)(14)(15). Plants are a rich source of constituents with antidiabetic and antioxidant properties, such as flavonoids, gallotannins, amino acids, and other polyphenolics (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

The potentials of Robusta (Coffea Robusta L.) and Arabica (Coffea Arabica L.) coffee leaf by-product as anti-diabetic drinks

Fibrianto,

Azarul ‘Izza,

Martati

et al. 2023

Canrea

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1) Background: It has been known that coffee leaf contain various bioactives and antioxidants. While diabetes can be indicated by the damage of pancreatic beta cells, numerous studies have reported that many kinds of antioxidants can recover the beta cells. As a result, coffee leaf tea has the potential to be developed as an anti-diabetic beverage. The current study used in vivo experiments to investigate the functionality of coffee leaf tea for diabetic therapy; 2) Methods: Robusta and Arabica coffee leaf were processed as oolong tea. All samples were soft-infused. Healthy and diabetic rats (induced with STZ intraperitonially at 80 mg/kg BW) were treated by injecting the softly infused coffee leaf tea 12 ml/kg BW/day for 28 days; 3) Results: Compared to the glibenclamide treatment, diabetic rats injected with Robusta coffee leaf tea were better at lowering blood sugar (p-value <0.05), as well as maintaning body weight. This is supported by the fact that the number of pancreatic beta cells in diabetic rats injected with Robusta coffee leaf tea was significantly higher than in glibenclamide treated rats (pvalue <0.05). Coffee leaf tea tend to have a lighter sensory profile than oolong tea; 4) Conclusions: It can be concluded that Robusta coffee leaf tea tends to be potentially developed as anti-diabetic drink since it can recover damaged pancreatic beta cells better than glibenclamide, thus helping to decrease blood sugar.

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