In vivo and In vitro study of the Neuroinfection and Neuropathogeny induced by dengue virus

Myriam, Velandia; Maria, Calderon; Sigrid, Camacho; Sandra, Aguilera; Maryi, Pardo; Beltran, Edgar; Jaime, Castellanos

doi:10.3389/conf.fncel.2015.35.00014

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raman shifts at 603, 633, 1043, 1055, 1095 and 1191 cm −1 are assigned to glutamate. It is reported that DENV infection induces glutamate excitotoxicity by releasing more glutamate in the synaptic cleft [35]. In this study, it is found to be positively correlated with AI of IgG and it was reported to be positively correlated in the IgM study as well.…”

Section: Analysis Of Regression Coefficientssupporting

confidence: 62%

Raman spectroscopy based screening of IgG positive and negative sera for dengue virus infection

Bilal¹,

Saleem²,

Bial³

et al. 2017

Laser Phys. Lett.

View full text Add to dashboard Cite

A quantitative analysis for the screening of immunoglobulin-G (IgG) positive human sera samples is presented for the dengue virus infection. The regression model was developed using 79 samples while 20 samples were used to test the performance of the model. The R-square (r 2 ) value of 0.91 was found through a leave-one-sample-out cross validation method, which shows the validity of this model. This model incorporates the molecular changes associated with IgG. Molecular analysis based on regression coefficients revealed that myristic acid, coenzyme-A, alanine, arabinose, arginine, vitamin C, carotene, fumarate, galactosamine, glutamate, lactic acid, stearic acid, tryptophan and vaccenic acid are positively correlated with IgG; while amide III, collagen, proteins, fatty acids, phospholipids and fucose are negatively correlated. For blindly tested samples, an excellent agreement has been found between the model predicted, and the clinical values of IgG. The parameters, which include sensitivity, specificity, accuracy and the area under the receiver operator characteristic curve, are found to be 100%, 83.3%, 95% and 0.99, respectively, which confirms the high quality of the model.

show abstract

Section: Analysis Of Regression Coefficientssupporting

confidence: 62%