In vivo and in vitro studies on soft denture materials: microbial adhesion and tests for antibacterial activity

Okita, Nobuko; Ørstavik, Dag; Ørstavik, Jon; Østby, Kari-Anne

doi:10.1016/0109-5641(91)90035-w

Cited by 73 publications

(48 citation statements)

References 16 publications

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“…The lack of such a relation has been similarly reported in two published studies 4,7) . This lack of mucosal response to fungal colonization could be explained by the fact that the patients chosen for our study had no acute problems or no indications of denture stomatitis; they were generally healthy at the beginning of the study 22) . Moreover, most of the dentures followed in our study were lower dentures, and the inflammatory changes related to denture stomatitis were reported to occur rarely under the lower dentures 23) .…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study on the Clinical Performance of Polysiloxane Soft Liners: One-year Results

et al. 2008

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Objective: The aim of the present study was to evaluate the clinical performance of four denture soft liners up to 12 months. Materials and methods: Thirty-three edentulous patients who experienced difficulties when using hard denture bases because of changes in denture-supporting tissues were accepted for the study and randomly received Molloplast B, GC Reline Soft, Silagum Comfort, or Mollosil Plus relines. Performance of the materials was evaluated using nine criteria at 3, 6, and 12 months: physical integrity, surface detail, adhesion, color, odor, plaque accumulation, resilience, hygiene, and mucosal condition. A four-point categorized scale (1＝poor, 2＝fair, 3＝good, 4＝excellent) was used. Unscheduled maintenance events and the presence of fungal colonization were also recorded. Results: The percentage of patients available at 3, 6, and 12 months were 91%, 91%, and 66%. Main reasons for dropouts and discontinuation were fractured dentures and patient dissatisfaction. At 6 months, 96% of the performance scores were good or excellent and the largest changes were observed for physical integrity, surface detail, color, and fungal colonization. Fungal colonization was the most commonly observed problem and was the only reason of failure at 12 months. Conclusions: The clinical performance of all soft liners was slightly impaired over the 12-month observation. Except for cases showing extensive fungal colonization, the observed changes in clinical performance did not necessitate remaking of the dentures. Mollosil Plus showed a performance comparable to that of Molloplast B, and the other materials had slightly lower performance especially in terms of fungal colonization.

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Section: Discussionmentioning

confidence: 99%

A Prospective Study on the Clinical Performance of Polysiloxane Soft Liners: One-year Results

et al. 2008

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“…Adherence is increased on rough acrylic and silicone rubber surfaces compared with smooth surfaces (Verran and Maryan, 1997). The acrylic base for dentures supported less adherence of C. albicans than tissue conditioners and a soft liner (Okita et al, 1991). As dental prostheses are exposed to saliva and oral bacteria, a complex biofilm develops to which C. albicans cells can adhere.…”

Section: Removalmentioning

confidence: 95%

Oral Colonization By Candida Albicans

Cannon

Chaffin

1999

Critical Reviews in Oral Biology & Medicine

277

193

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Candida albicans is a commensal yeast normally present in small numbers in the oral flora of a large proportion of humans. Colonization of the oral cavity by C. albicans involves the acquisition and maintenance of a stable yeast population. Micro-organisms are continually being removed from the oral cavity by host clearance mechanisms, and so, in order to survive and inhabit this eco-system, C. albicans cells have to adhere and replicate. The oral cavity presents many niches for C. albicans colonization, and the yeast is able to adhere to a plethora of ligands. These include epithelial and bacterial cell-surface molecules, extracellular matrix proteins, and dental acrylic. In addition, saliva molecules, including basic proline-rich proteins, adsorbed to many oral surfaces promote C. albicans adherence. Several adhesins present in the C. albicans cell wall have now been partially characterized. Adherence involves lectin, protein-protein, and hydrophobic interactions. As C. albicans cells evade host defenses and colonize new environments by penetrating tissues, they are exposed to new adherence receptors and respond by expressing alternative adhesins. The relatively small number of commensal Candida cells in the oral flora raises the possibility that strategies can be devised to prevent oral colonization and infection. However, the variety of oral niches and the complex adherence mechanisms of the yeast mean that such a goal will remain elusive until more is known about the contribution of each mechanism to colonization.

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“…Although these reports 1M indicate the in vitro inhibitory effects of antifungals on candidal growth, the nutrient-rich environment and the cleansing effect of the oral cavity are likely to minimize the beneficial action in vivo (Graham et al, 1991;Okita et al, 1991). Further, the dosages of the antifungals used in these in vitro studies appear to be high, costly, and impractical in clinical situations.…”

mentioning

confidence: 97%

Oral Candidal Infections and Antimycotics

Ellepola

Samaranayake

2000

Critical Reviews in Oral Biology & Medicine

210

236

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The advent of the human immunodeficiency virus infection and the increasing prevalence of compromised individuals in the community due to modern therapeutic advances have resulted in a resurgence of opportunistic infections, including oral candidoses. One form of the latter presents classically as a white lesion of "thrush" and is usually easily diagnosed and cured. Nonetheless, a minority of these lesions appears in new guises such as erythematous candidosis, thereby confounding the unwary clinician and complicating its management. Despite the availability of several effective antimycotics for the treatment of oral candidoses, failure of therapy is not uncommon due to the unique environment of the oral cavity, where the flushing effect of saliva and the cleansing action of the oral musculature tend to reduce the drug concentration to sub-therapeutic levels. This problem has been partly circumvented by the introduction of the triazole agents, which initially appeared to be highly effective. However, an alarming increase of organisms resistant to the triazoles has been reported recently. In this review, an overview of clinical manifestations of oral candidoses and recent advances in antimycotic therapy is given, together with newer concepts, such as the post-antifungal effect (PAFE) and its possible therapeutic implications.

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In vivo and in vitro studies on soft denture materials: microbial adhesion and tests for antibacterial activity

Cited by 73 publications

References 16 publications

A Prospective Study on the Clinical Performance of Polysiloxane Soft Liners: One-year Results

A Prospective Study on the Clinical Performance of Polysiloxane Soft Liners: One-year Results

Oral Colonization By Candida Albicans

Oral Candidal Infections and Antimycotics

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