In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis

Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva

“…They can also be used effectively against MEZ-resistant strains of T. vaginalis and recurrent periodontitis [4,5]. TNZ has been widely used in Europe as well as developing countries for over two decades with an established efficacy and an acceptable tolerability [6].…”

Spectrophotometric Determination of Ornidazole, Secnidazole and Tinidazole in Pharmaceutical Preparations Based on Formation of Dyes

“…Due to its antimicrobial activity it inhibits the growth of both anaerobic bacteria and certain anaerobic protozoa such as trichomonas, vaginalis, entamoeba histolytica and giardina iamboa (1) . Various methods were used in the determination of ornidazole (I) including high performance liquid chromatography (2,3) , high performance thin layer chromatography (4,5) , electrophoresis (6) and spectrophotometery (7) , for secnidazole (II) high performance liquid chromatography (8,9) , electrochemical method (10) and spectrophotometery (11) and for tinidazole (III) high performance liquid chromatography (12) , electrochemical method (13) , spectrophotometery (14) and electrophoresis (6) .…”

Automatic Multisyringe Flow Injection System for the Spectrophotometric Determination of Tinidazole in Pharmaceutical Preparations

“…Additionally, TNZ has shown a greater tolerability, a longer half-life, and a more favorable side-effect profile than MTZ [3,4]; therefore, analytical methods for its quantification are required for quality control purpose. Several analytical methods for the determination of TNZ in pharmaceutical preparations, feedstuff or human plasma have been developed, including high performance liquid chromatography (HPLC) [9,10], capillary electrophoresis (CE) [11,12], liquid chromatography-mass spectrometry (LC-MS) [13], voltammetry [14], electrochemical methods [15], resonance light scattering (RLS) [16] and spectrophotometry [5,17,18].…”