In vivo anti-arthritic efficacy of Camellia sinensis (L.) in collagen induced arthritis model

In Vivo and In Vitro Anti-Arthritic Effects of Cardenolide-Rich and Caffeoylquinic Acid-Rich Fractions of Periploca forrestii

“…RA is a chronic inflammatory disease characterized by pain, swelling, and joint destruction, of which severe cases can lead to deformity and even disability [ 11 , 20 ]. As the pathological characteristics and processes of the CIA model are very similar to clinical human rheumatoid arthritis [ 21 , 22 ], the CIA model is one of the models widely used for RA study and was employed to evaluate the anti-arthritic effects of CDLF and CQAF in the present study. Joint destruction, synovial hyperplasia, and inflammatory infiltration are important characteristics of the RA pathological process [ 23 ].…”

“…Elevated oxidative stress factors, such as MDA and NO, are often considered as biomarkers of inflammation, along with decreased the activity of SOD [ 21 ]. A decrease in SOD activity and increases in serum MDA and NO were observed in CIA rats.…”

“…After adapting to the housing conditions for seven days, rats were randomly divided into nine groups ( n = 8) and treated with TGT in the dose of 37.5 mg/kg, CDLF or CQAF in doses of 125 mg/kg, 250 mg/kg, and 500 mg/kg. A pathologic model of arthritis was established as previously described [ 21 , 39 ]. Briefly, bovine type II collagen (CII) was dissolved in acetic acid (0.05 M) to a concentration of 2.0 mg/mL, then emulsified with an equal volume of complete Freund’s adjuvant (CFA).…”

Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS)

“…Plasma samples was prepared by centrifuging the blood at 3000 rpm for 15 min at 4 °C and stored at −80 °C. The preparation of ankle joints tissue was performed as described previously [ 50 ]. All of the ankle joints tissues were stored at liquid nitrogen for RNA and protein extraction.…”

DAP Inhibits the TNF-α-Induced Inflammatory Response by Modulating the MAPK Signaling Pathway in Synovial Cells

“…Rheumatoid arthritis (RA) is a typical systemic autoimmune disease that is characterized by the abnormal hyperplasia of synovial cells, progressive in ltration of in ammatory cells in joint parts, formation of pannus, destruction of bone and cartilage and production of autoantibodies, which lead to joint deformity, loss of function, long disease course, poor prognosis, extensive disability, and serious impacts on the quality of life (1)(2)(3). The pathogenesis of RA has not been fully elucidated, but studies have shown that the abnormal activation of a signal transduction pathway is an important factor that causes abnormal proliferation of synovial cells and excessive secretion of in ammatory factors and plays an important role in the pathogenesis of RA(4-7).…”