In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy

Li, Tsung‐Ju; Huang, Chih Chia; Ruan, Pin; Chuang, Kuei Yi; Huang, Kuang Jing; Shieh, Dar Bin; Yeh, Chen Sheng

doi:10.1016/j.biomaterials.2013.07.012

Cited by 94 publications

(56 citation statements)

References 47 publications

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“…35,[38][39][40][41] Furthermore, in the area of medical imaging, FePt NPs are considered to have great potential in MRI and MRI/CT dual-model imaging as a regenerative medicine. 31,33 However, we confirm that there is still a paucity of research on FePt NPs in the radiotherapy field, in which the NPs may hold potential.…”

Section: Discussionmentioning

confidence: 99%

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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Nanomaterials have an advantage in “personalized” therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray diffraction; transmission electron microscopy, Physical Property Measurement System, and Fourier transform infrared spectroscopy. The cytotoxicity of FePt NPs on Vero cells was assessed using an MTT assay, and tumor cell proliferation inhibited by individual FePt NPs and FePt NPs combined with X-ray beams were also collected using MTT assays; HeLa human cancer cell lines were used as in vitro models. Further confirmation of the combined effect of FePt NPs and X-rays was verified using HeLa cells, after which, the cellular uptake of FePt NPs was captured by transmission electron microscopy. The results indicated that the growth of HeLa cells was significantly inhibited by FePt NPs in a concentration-dependent manner, and the growth was significantly more inhibited by FePt NPs combined with a series of X-ray beam doses; the individual NPs did not display any remarkable cytotoxicity on Vero cells at a concentration <250 μg/mL. Meanwhile, the FePt NPs showed negative/positive contrast enhancement for MRI/CT molecule imaging at the end of the study. Therefore, the combined results implied that FePt NPs might potentially serve as a promising nanoprobe for the integration of tumor diagnosis and chemoradiotherapy.

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Section: Discussionmentioning

confidence: 99%

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Zheng¹,

Tang²,

Bao³

et al. 2015

IJN

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“…In recent years, the synthesis of magnetic iron oxide nanoparticles (particularly magnetite -Fe 3 O 4 ) has been intensively explored with a view to biomedical applications such as targeted drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia [1][2][3][4][5][6][7][8] . Multifunctional materials are attractive because they may combine properties, which allow manipulation chemical functionalities, playing a key role in different applications.…”

Section: Introductionmentioning

confidence: 99%

Luminescent and Magnetic Properties of Fe3O4@SiO2:phen:Eu3+

2017

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Magnetite was doped with rare earth ions (europium) to produce core-shell materials with both magnetic and luminescent properties, i.e., a magnetic Fe 3 O 4 oxide core and a SiO 2 :phen:Eu 3+ shell. The resulting material was analyzed by X-ray powder diffraction and transmission electron microscopy, and subjected to magnetic and luminescence emission measurements. All the synthesized materials exhibited superparamagnetic behavior and luminescence emission. The magnetic behavior of Fe 3 O 4 and luminescence emission of SiO 2 :phen:Eu 3+ of the materials were compared to precursors.

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“…Li et al functionalized a magnetite core with PMSA followed by covalent modification with poly-A15 [254]. The nanoparticles were then functionalized with 5-FU and tagged with a HER2 antibody as shown in Figure 11a.…”

Section: Combination Therapymentioning

confidence: 99%

“…(b) Tumor volume of tumors treated with magnetically mediated hyperthermia using 5-FU functionalized nanoparticles which were targeted to HER2 grew significantly slower than the other treatments. Taken with permission from reference [254]. …”

Section: Figurementioning

confidence: 99%

Magnetic nanoparticles and nanocomposites for remote controlled therapies

Hauser

Wydra

Stocke

et al. 2015

Journal of Controlled Release

108

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This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

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In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy

Cited by 94 publications

References 47 publications

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells

Luminescent and Magnetic Properties of Fe3O4@SiO2:phen:Eu3+

Magnetic nanoparticles and nanocomposites for remote controlled therapies

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