In Vivo Anti-Diabetic Activity Evaluation of the Bark of Cascabela Thevetia L. In Streptozotocin Induced Diabetic Rats

Gogoi, Neelutpal; Bhuyan, Biman

doi:10.22159/ijpps.2017v9i6.17200

Cited by 6 publications

(9 citation statements)

References 19 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The active binding site coordinates took for the docking study were X: 199.351540,Y: 219.641972, Z: 178.491488 and radius:11.225346 Å for 5YW7; and X: 203.022540,Y: 281.546343, Z: 218.193527and radius:11.899795 Å for 6PZA ( Figure S1 ). Then the docking was performed using the simulation‐based docking protocol ‘CDocker’ of DS 2018 [33] . Before docking of the test compound MEA, redocking of the co‐crystal ligand (glibenclamide) was done to validate the study and the docking poses of the glibenclamide were compared with the original co‐crystal pose to calculate the RMSD values ( Figure S2 ).…”

Section: Methodsmentioning

confidence: 99%

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

Singh,

Chetia,

Gogoi

et al. 2023

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

Allium hookeri (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant antidiabetic potential in rats. In the present study, we evaluated the antidiabetic potential of a flavonoid compound named MEA isolated from the methanolic leaf extract of A. Hookeri in rats. Additionally, we assessed the compound's mode of action through the molecular docking study. The MEA reduced the blood glucose level from 317±12.8 to 99.4±6.67 mg/dl after 21 days of treatment. Besides, MEA also restored the body weights and other biochemical parameters including lipid profile significantly compared to the diabetic group (p<0.001). The histoarchitecture of the pancreatic tissues of the MEA treated group was also improved compared to the diabetic group. In the docking study, the compound showed good binding affinity in the active binding site of the two structures of pancreatic beta‐cell SUR1 (Sulfonylurea Receptor 1) subunit with CDocker energy −31.556 kcal/mol and −39.703 kcal/mol, respectively. The compound MEA was found to be drug‐like with non‐carcinogenic, non‐mutagenic and non‐irritant properties. These findings indicate the antidiabetic potential of MEA, which might act by modulating the pancreatic beta‐cell SUR1 subunit present in the KATP channel. Hence, the MEA would be a promising lead molecule to develop new antidiabetic drug candidates of the future.

show abstract

Section: Methodsmentioning

confidence: 99%

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

Singh,

Chetia,

Gogoi

et al. 2023

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

show abstract

“…><0.01 by using one-way analysis of variance followed by Dunnet comparison all vs. control method. Further isolation of the compounds can lead to finding out the exact compound responsible for the activity, but furthermore, studies like molecular level and clinical level studies are required to establish its importance as a potent medicinal plant 35 .…”

Section: Antidiarrhoeal Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

In any nation's public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, cardiac glycosides, and other secondary metabolites are found in Thevetia peruviana. All parts of these plants are toxic and contain a variety of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin. The leaves of the plant are used as a cardiotonic and diuretic and are also reported to possess medicinal value in traditional systems of medicine. Several studies reported pharmacological activity in various plant parts, including seeds, flowers, bark, fruits and leaves. The purpose of this review is to provide the complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & pharmacological activities. INTRODUCTION:Thevetia peruviana, commonly known as yellow oleander in English and Peeli Kaner in Hindi, is widespread throughout the India. The plant is mostly used as an ornamental in gardens, road dividers along the sides of roads. It does not require any maintenance and can easily survive in extreme conditions 1 . It requires minimum water when it is in its growing stage. It began flowering after one & a half years. It blooms three times a year. Fruit contains 2-4 flat gray seeds, yield about half a liter of oil from 1 kg of dry kernel 2 . It grows to about 10-18 feet high, with spirally arranged, linear leaves about 13 to 15 cm in length 3 .

show abstract

“…Blood samples were collected from the tail vein of the overnight fasted rats and blood glucose level was determined on 0 th , 5 th , 10 th and 15 th day along with body weight. On the 15 th day, all the animals were humanely sacrificed using CPCSEA recommended euthanasia procedure (Carbon dioxide inhalation method) and evaluated for the biochemical parameters along with histopathology of the pancreas tissue 7 . Alkaloid-the secondary metabolite present in plants has been investigated for antidiabetic activity.…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Alangium salvifolium is a plant that is traditionally used to treat many diseases like laxative, antiepileptic, jaundice, antiulcer agent, agent to alleviate spasms, anthelmintic, emetic, antiprotozoal agent and hypoglycemic agent. Its subspecies Alangium salvifolium subsp. Hexapetalum (Wangerin) is also known for a variety of traditional use like hemorrhoids, rheumatism, and antidote for snake bite. The present work aims for the evaluation of the in-vitro and in-vivo anti-diabetic activity of methanolic extract of aerial parts of Alangium salvifolium subsp. Hexapetalum (Wangerin). The in-vitro antidiabetic activity was evaluated by a starch-iodine color assay method. The in-vivo method was performed by administering orally the methanolic extract of Alangium salvifolium subsp. Hexapetalum in streptozotocin-induced male Albino Wistar rats weighing 200 g. The study was compared using standard metformin hydrochloride (10 mg/kg body weight). The in-vitro method showed a dose-dependent anti-diabetic activity that is as the dose increases the percentage inhibition of enzyme activity also increases. The in-vivo anti-diabetic activity was accessed by comparing the body weight and blood glucose level on 0 th , 5 th , 10 th and 15 th day using a glucometer. Thus, the present study reveals that the methanolic extract of aerial parts of Alangium salvifolium subsp. Hexapetalum (Wangerin) was efficient in lowering blood glucose levels.

show abstract

In Vivo Anti-Diabetic Activity Evaluation of the Bark of Cascabela Thevetia L. In Streptozotocin Induced Diabetic Rats

Cited by 6 publications

References 19 publications

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

Untitled

Untitled

Contact Info

Product

Resources

About