In Vivo Anti-diabetic and Anti-oxidant Potential of Psoralea corylifolia Seeds in Streptozotocin Induced Type-2 Diabetic Rats

Kamboj, Jitpal; Sharma, Swati; Kumar, Suresh

doi:10.1248/jhs.57.225

Cited by 22 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have examined the anti-diabetic efficacy of PC in a type 2 DM animal model. The ethanol extract of PC exhibit anti-hyperglycemic and antioxidative effects in type 2 DM rats by increasing plasma insulin level and decreasing blood glucose, glycosylated hemoglobin, and total plasma cholesterol levels [ 4 ]. Water extract of PC protects β cells against oxidative stress [ 5 ] and improves insulin sensitivity in streptozocin-induced diabetic rats [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes

Lee

Noh

et al. 2016

IJMS

View full text Add to dashboard Cite

The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as “Bo-Gol-Zhee” in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total plasma cholesterol levels in type 2 diabetic rats. In this study, we purified six compounds from PC and investigated their anti-diabetic effect. Among the purified compounds, bavachin most potently accumulated lipids during adipocyte differentiation. Intracellular lipid accumulation was measured by Oil Red-O (ORO) cell staining to investigate the effect of compounds on adipogenesis. Consistently, bavachin activated gene expression of adipogenic transcriptional factors, proliferator-activated receptorγ (PPARγ) and CCAAT/enhancer binding protein-α (C/EBPα). Bavachin also increased adiponectin expression and secretion in adipocytes. Moreover, bavachin increased insulin-induced glucose uptake by differentiated adipocytes and myoblasts. In differentiated adipocytes, we found that bavachin enhanced glucose uptake via glucose transporter 4 (GLUT4) translocation by activating the Akt and 5′AMP-activated protein kinase (AMPK) pathway in the presence or absence of insulin. These results suggest that bavachin from Psoralea corylifolia might have therapeutic potential for type 2 diabetes by activating insulin signaling pathways.

show abstract

Section: Introductionmentioning

confidence: 99%

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes

Lee

Noh

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…The anti-diabetic and anti-oxidant potential of ethanolic extract of seeds of Psoralea corylifolia were investigated in streptozatocin (STZ) nicotinamide induced type 2-diabetic rats. The findings indicate that Psoralea corylifolia has significant anti-hyperglycemic and antioxidant activity [33] .…”

Section: Anti-diabetic Activitymentioning

confidence: 96%

Pharmacological investigations of Babchi (Psoralea corylifolia Linn) – An important drug of Unani system of medicine

Bi¹,

Akhtar²,

Bashir³

et al. 2020

Int. J. Unani. Integ. Med.

View full text Add to dashboard Cite

Babchi (Psoralea corylifolia Linn) is an important medicinal plant which is used in Unani System of Medicine since along. Ancient Unani physicians have reported use of Babchi seeds in the treatment of different diseases especially skin diseases e.g. Bars (Leucoderma), Da-us-sadaf (Psoriasis), Bahaq (Pityriasis), Tap-e Balghamiya (Phlegmatic Fever), Deedan-e-Am'aa (Intestinal worms) and other inflammatory diseases of the skin. Several studies were conducted to validate the therapeutic potentials of the plant and it was observed that besides the aforesaid pharmacological actions, the plant extracts also possesses antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal and immunomodulatory activity. The present paper is an effort to document the pharmacological investigations of Babchi (Psoralea corylifolia Linn) with evidence-based approach.

show abstract

“…Psoralea corlifolia is a medicinal herb grown in Asia and India [101]. It possesses an antitumor [102], anti-diabetic [103], antibacterial [104], antioxidant, stimulant, and vasodilator activity [105]. EE, WE and ChE of P. corlifolia seeds are used to evaluate their activity against AR using the method described by Suryanarayana et al [15] DL glyceraldehydes is used in this study as substrate.…”

Section: Psoralea Corlifolia (Fabaceae)mentioning

confidence: 99%

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

2022

View full text Add to dashboard Cite

Summary Introduction: Aldose reductase (AR) is an enzyme that catalyzes the reduction of glucose to sorbitol responsible for the development of diabetic complications like cataracts. Medicinal plants contain several phytocompounds that can inhibit this enzyme. Objective: The purpose of this review is to cite medicinal plants that have been tested for their ability to inhibit aldose reductase and consequently prevent cataracts and classify the major isolated compounds that have this activity. Methods: We reviewed 154 articles published between 1954 and 2020 in English via three databases: ScienceDirect, Web of Science, and PubMed. We have classified the plants that showed a significant anti-cataract effect, in the form of a list including the scientific and family names of each plant. Also, we have cited the IC50 values and the active constituents of each plant that showed inhibitory activity towards AR. Results: We have described 38 herbs belonging to 29 families. Besides, 47 isolated compounds obtained from the cited herbs have shown an AR inhibitory effect: luteolin, luteolin-7-O-β-D-glucopyranoside, apigenin, 3,5-di-O-caffeoyl-epi-quinic acid, delphinidin 3-O-β-galactopyranoside-3’-O-β-glucopyranoside, 3,5-di-O-caffeoylquinic acid methyl ester, andrographolide, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2,4,6-tetra-O-galloyl-β-D-glucose, 7-(3-hydroxypropyl)-3-methyl-8-β-O-D-glucoside-2H-chromen-2-one, E-4-(60-hydroxyhex-30-en-1-yl)phenyl propionate, delphinidin 3-O-β-galactopyranoside-3’,5’-di-O-β-glucopyranoside, 1,2,3-tri-O-galloyl-β-D-glucose, 1,2,3,4,6-penta-O-galloyl-β-D-glucose, 1,2,6-tri-O-galloyl-β-D-glucose, 2-(4-hydroxy-3-methoxyphenyl)ethanol, (4-hydroxy-3-methoxyphenyl)methanol, trans-anethole, gallic acid 4-O-β-D-(6’-O-galloyl)-glucoside, β-glucogallin, puerariafuran, quercetin, gallic acid 4-O-β-D-glucoside, 2,5-dihydroxybenzoic acid, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone, protocatechuic acid, trans-cinnamic acid, gallic acid, p-coumaric acid and syringic acid. Conclusion: natural therapy becomes an interesting alternative in the treatment and prevention of cataract by using medicinal plants rich in active compounds considered as AR inhibitors.

show abstract

In Vivo Anti-diabetic and Anti-oxidant Potential of Psoralea corylifolia Seeds in Streptozotocin Induced Type-2 Diabetic Rats

Cited by 22 publications

References 35 publications

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes

Pharmacological investigations of Babchi (Psoralea corylifolia Linn) – An important drug of Unani system of medicine

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

Contact Info

Product

Resources

About