In Vivo Anti-Inflammatory, Analgesic, Muscle Relaxant, and Sedative Activities of Extracts from Syzygium cumini (L.) Skeels in Mice

Al-Awthan, Yahya S.; Khan, Imtaiz Ali; Muhammad, Naveed; Shah, Syed Muhammad Hassan; Bahattab, Omar; Al-Duais, Mohammed A.; Sharma, Rohit; Rahman, Md. Mominur

doi:10.1155/2022/6307529

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…Nitrogenous pollutants and fne and ultrafne particles conduce vaso-control. Also, they may cause synaptic infammation as they pass through the blood-brain barrier (BBB) and reach the brain, therefore, paving the way for future neuro dysregulations [15,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]. Pesticides, chemically generated fertilizers, dyes, detergents, and heavy metals are all making their way into aquatic systems, posing a threat to human health [62].…”

Section: On Humansmentioning

confidence: 99%

Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues

Rahman

Ahmed

Anika

et al. 2023

Bioinorganic Chemistry and Applications

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Nowadays, environmental pollution has become a critical issue for both developed and developing countries. Because of excessive industrialization, burning of fossil fuels, mining and exploration, extensive agricultural activities, and plastics, the environment is being contaminated rapidly through soil, air, and water. There are a variety of approaches for treating environmental toxins, but each has its own set of restrictions. As a result, various therapies are accessible, and approaches that are effective, long-lasting, less harmful, and have a superior outcome are extensively demanded. Modern research advances focus more on polymer-based nanoparticles, which are frequently used in drug design, drug delivery systems, environmental remediation, power storage, transformations, and other fields. Bioinorganic nanomaterials could be a better candidate to control contaminants in the environment. In this article, we focused on their synthesis, characterization, photocatalytic process, and contributions to environmental remediation against numerous ecological hazards. In this review article, we also tried to explore their recent advancements and futuristic contributions to control and prevent various pollutants in the environment.

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Section: On Humansmentioning

confidence: 99%

Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues

Rahman

Ahmed

Anika

et al. 2023

Bioinorganic Chemistry and Applications

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“…Therapy with oral glucocorticoids usually results in a positive outcome. Plasmapheresis and intravenous immunoglobulin (IVIG) are also successful treatments [194,223,[230][231][232][233][234][235][236]. 9.4.…”

Section: 3mentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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Based on the diverse physiological influence, the impact of glial cells has become much more evident on neurological illnesses, resulting in the origins of many diseases appearing to be more convoluted than previously happened. Since neurological disorders are often random and unknown, hence the construction of animal models is difficult to build, representing a small fraction of people with a gene mutation. As a result, an immediate necessity is grown to work within in vitro techniques for examining these illnesses. As the scientific community recognizes cell-autonomous contributions to a variety of central nervous system illnesses, therapeutic techniques involving stem cells for treating neurological diseases are gaining traction. The use of stem cells derived from a variety of sources is increasingly being used to replace both neuronal and glial tissue. The brain’s energy demands necessitate the reliance of neurons on glial cells in order for it to function properly. Furthermore, glial cells have diverse functions in terms of regulating their own metabolic activities, as well as collaborating with neurons via secreted signaling or guidance molecules, forming a complex network of neuron-glial connections in health and sickness. Emerging data reveals that metabolic changes in glial cells can cause morphological and functional changes in conjunction with neuronal dysfunction under disease situations, highlighting the importance of neuron-glia interactions in the pathophysiology of neurological illnesses. In this context, it is required to improve our understanding of disease mechanisms and create potential novel therapeutics. According to research, synaptic malfunction is one of the features of various mental diseases, and glial cells are acting as key ingredients not only in synapse formation, growth, and plasticity but also in neuroinflammation and synaptic homeostasis which creates critical physiological capacity in the focused sensory system. The goal of this review article is to elaborate state-of-the-art information on a few glial cell types situated in the central nervous system (CNS) and highlight their role in the onset and progression of neurological disorders.

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“…5 Ototoxicity refers to the damage caused by drugs that affect the structure of the inner ear and related neural tissues, resulting in cochlear or vestibular dysfunction. [6][7][8][9][10][11] DDP-induced human ototoxicity was more dominant in the cochlea than in the vestibular apparatus. 12 The mechanism of DDP-induced cochlear dysfunction has been associated with cell damage and the destruction of cochlear homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle

Chen,

Xiang,

et al. 2023

Int J Toxicol

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Antioxidant 1 copper chaperone (Atox1) may contribute to preventing DDP cochlear damage by regulating copper transport family and cell cycle proteins. A rat model of cochlear damage was developed by placing gelatin sponges treated with DDP in the cochlea. HEI-OC1 cells were treated with 133 μM DDP as a cell model. DDP-induced ototoxicity in rats was confirmed by immunofluorescence (IF) imaging. The damage of DDP to HEI-OC1 cells was assessed by using CCK-8, TUNEL, and flow cytometry. The relationship between Atox1, a member of the copper transport protein family, and the damage to in vivo/ vitro models was explored by qRT-PCR, western blot, CCK-8, TUNEL, and flow cytometry. DDP had toxic and other side effects causing cochlear damage and promoted HEI-OC1 cell apoptosis and cell cycle arrest. The over-expression of Atox1 (oe-Atox1) was accomplished by transfecting lentiviral vectors into in vitro/ vivo models. We found that oe-Atox1 increased the levels of Atox1, copper transporter 1 (CTR1), and SOD3 in HEI-OC1 cells and decreased the expression levels of ATPase copper transporting α (ATP7A) and ATPase copper transporting β (ATP7B). In addition, the transfection of oe-Atox1 decreased cell apoptosis rate and the number of G2/M stage cells. Similarly, the expression of myosin VI and phalloidin of cochlea cells in vivo decreased. Atox1 ameliorated DDP-induced damage to HEI-OC1 cells or rats' cochlea by regulating the levels of members of the copper transport family.

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In Vivo Anti-Inflammatory, Analgesic, Muscle Relaxant, and Sedative Activities of Extracts from Syzygium cumini (L.) Skeels in Mice

Cited by 10 publications

References 26 publications

Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues

Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle

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