In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

“…The original EtOH extract and its EtOAc and n-BuOHs fractions exhibited significant anti-inflammatory activity in carrageenan-induced and PGE 1 -induced hind paw edema models, as well as on an acetic acid-induced increase in a vascular permeability model. 2 However, in the carrageenaninduced hind paw edema model, neither of the fractions were as efficient as the mother EtOH extraction, nor was any of the rose hip extract or fractions as efficient as the indomethacin reference anti-inflammatory agent. In the PGE 1 -induced hind paw edema model, the EtOH extract and its EtOAc and BuOH fractions also inhibited the inflammatory swellings of the footpad as good as did the reference anti-inflammatory agent, albeit that indomethacin's effect occurred in a shorter timespan.…”

“…2 Anti-inflammatory activity was estimated using the carrageenan-induced hind paw edema model, the difference in foot pad thickness between the right carrageenan infused and left (no infusion) foot was measured and gave the magnitude of anti-inflammatory activity. 3 Antinociceptive activity was estimated using the p-benzoquinone-induced abdominal constriction test -the number of constrictions giving the amount of pain.…”

Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a mouse model of hyperuricemia

“…The different methods of extracting rosehip also generated different strengths of inhibitory effect, namely, the hot water and ethanol extracts exhibited markedly stronger dose-dependent inhibition of XO activity when compared with the ethyl acetate extract. Numerous studies have suggested that the particular polarity of an extraction solvent affects the biological activity of the extract (20,41,42); for example, the free radical scavenging activities associated with extracts of Galla chinensis, a traditional Chinese herb, were in the following order: Ethyl acetate (weak polarity) >ether polarity), because an antioxidant phytochemical, tannin, in this extract is soluble in non-polar or weak polar solvents (41). Certain studies have reported that polyphenols, flavonoids and saponins are potent XO inhibitors (43)(44)(45)(46), and rosehip contains numerous phenolic phytochemicals (47).…”

“…Therefore, the risk of interaction between rosehip hot water extract and CYP3A4 substrate drugs appears to be low. Furthermore, other studies reported that ethyl acetate, n-butanol and ethanol extracts from rosehip did not induce toxicity in an acute toxicity test in mice (20), and favorable results were obtained from clinical trials in osteoarthritis (49)(50)(51). Thus, the safety of rosehip has been confirmed by traditional experiences of its use, as well as by safety testing.…”

“…Rosehip has traditionally been administered for the treatment of colds, infectious diseases and inflammatory diseases (16). In support of its traditional uses, various studies have reported that rosehip exhibited bioactivity, including antioxidant (17,18), anti-inflammatory (19)(20)(21)(22), hepatoprotective (23), anti-diabetic (17) and anti-obesity (24) effects. Therefore, rosehip may be considered a functional food that promotes health.…”