In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants

Conforti, Filomena; Sosa, Silvio; Marrelli, Mariangela; Statti, Giancarlo; Uzunov, Dimitar; Tubaro, Aurelia; Menichini, Francesco; Loggia, R. Della

doi:10.1016/j.jep.2007.11.015

Cited by 263 publications

(178 citation statements)

References 44 publications

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“…Recently, it has also been reported that the extract of Malva sylvestris has wound-healing potential in alloxan-induced diabetic rats (Pirbalouti et al, 2010(Pirbalouti et al, , 2012. The extract of Malva sylvestris also has antiinflammatory and antiulcerogenic properties (Conforti et al, 2008;Sleiman and Daher, 2009;Pirbalouti et al, 2010;Gasparetto et al, 2012;Prudente et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Hussain¹,

Ikram²,

Rehman³

et al. 2014

Turk J Biol

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Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. The extract was concentrated using a rotary evaporator and then desired concentrations of extracts were made by dissolving in normal saline. The standard drug silymarin (100 mg/kg) was used as a reference drug to compare the therapeutic effects of Malva sylvestris. Two different doses of Malva sylvestris (300 and 600 mg/kg) were administered intraperitoneally for 7 consecutive days followed by intraperitoneal administration of paracetamol (250 mg/kg). Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract of Malva sylvestris significantly reduced the serum levels of these elevated liver enzyme markers in a dose-dependent manner. Histopathological examination of liver tissues also showed hepatoprotective effects of Malva sylvestris in restoring normal functional ability of the liver. The results of our study strongly suggest that the extract of Malva sylvestris has strong hepatoprotective effects against paracetamol-induced liver injury, thereby scientifically affirming its traditional therapeutic role in liver injury.

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Section: Introductionmentioning

confidence: 98%

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Hussain¹,

Ikram²,

Rehman³

et al. 2014

Turk J Biol

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“…The injection was made using a 10 µL microsyringe (HamiltonReno, NV, USA). Relative to the bregma and with the stereotaxic arm at 0°, the coordinates for the toothed gyrus were posterior -3.6; lateral α2.3; and dorsal 3 mm (Conforti and et al 2008).…”

Section: Intrahippocampal Injection Of Aβ β β β β25-35mentioning

confidence: 99%

Effect of Borage on hipocampal TNF-α protein and gene in the Amyloid β-Peptide(25–35)-Induced of Alzheimer model in rat

Barati¹,

Asl²,

Pourbakhsh³

et al. 2016

Biosci., Biotech. Res. Asia

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Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the investigating effect of Borago officinale on hipocampal TNF-α α α α α protein in the Beta Amyloid peptid induced of inflammation in the rat. Wistar male rats received intrahippocampal (IHP) injection of the Aβ β β β β(25-35) and borage extract orally (100 mg/ kg).inflamation was confirmed by pathologist.in order to measure the expression of the TNF-α α α α α gene , RT-PCR method and for extraction of the TNF-α α α α α protein western bloting method was used. results showed that using Borage lead to reduce TNF-α α α α α gene and protein. This data suggests that borage could improve the reduction of inflammation factors such as TNF-α α α α α and borage consumption may lead to an improvement of ADinduced cognitive dysfunction.

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“…In addition, oxidative damage of macromolecules and lipid peroxidation of cell structures, such as membranes, also occurs (Dryden et al, 2005;Valko et al, 2007). These events are the reason why ROS are strongly associated with many pathological conditions such as atherosclerosis, diabetes, cancer, cardiovascular diseases, and inflammation, among others (Dryden et al, 2005;Conforti et al, 2008). There is a wide array of scientific evidence about the role of ROS in the pathogenesis of inflammation (Nardi et al, 2007;Pashkow, 2011).…”

Section: Carrageenan-induced Rat Paw Edema Modelmentioning

confidence: 99%

“…Most of the steroidal and nonsteroidal drugs available on the market have a potent anti-inflammatory activity, but they also present many side effects (Geronikaki & Gavalas, 2006;Ziakas et al, 2006). The search of novel and low toxicity compounds with antioxidant and anti-inflammatory activity is now focused on natural products (Geronikaki & Gavalas, 2006;Conforti et al, 2008). In this sense, our work is relevant because it describes for the first time a significant antioxidant activity in MeOH extracts from flowers and also a significant anti-inflammatory activity in DC extracts from roots of Pittocaulon species.…”

Section: Carrageenan-induced Rat Paw Edema Modelmentioning

confidence: 99%

Antioxidant and anti-inflammatory activities ofPittocaulonspecies from México

Marín-Loaiza

Nieto‐Camacho

Céspedes

2012

Pharmaceutical Biology

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In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants

Cited by 263 publications

References 44 publications

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Effect of Borage on hipocampal TNF-α protein and gene in the Amyloid β-Peptide(25–35)-Induced of Alzheimer model in rat

Antioxidant and anti-inflammatory activities ofPittocaulonspecies from México

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