In vivo anti-inflammatory effect of Rosa canina L. extract

Lattanzio, Francesca; Greco, Emanuela; Carretta, Donatella; Cervellati, Rinaldo; Govoni, Paolo; Speroni, Ester

doi:10.1016/j.jep.2011.07.006

Cited by 90 publications

(59 citation statements)

References 37 publications

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“…Lattanzio et al 18 found dose-dependent anti-inflammatory activity of hydroalcoholic R. canina extracts in a carrageenaninduced rat paw edema assay, which was comparable to the reference drug, indomethacin. By contrast, Saaby 13 only found a trend to reducing paw edema 1-5 hours and again 24 hours after treatment of rats with dichloromethane:ethanol (1:1) rose hip extracts.…”

Section: Studies In Ratsmentioning

confidence: 88%

“…However, the animal model (mice) used and the extraction procedures for rose hip were different in the Deliorman Orhan et al 2 studies. Lattanzio et al 18 also detected some gastro-protection from extractions of rose hip seeds in rats subjected to ethanolinduced gastric damage. However, the anti-ulcerogenic effect was not statistically significant.…”

Section: Studies In Ratsmentioning

confidence: 96%

“…By contrast, Saaby 13 only found a trend to reducing paw edema 1-5 hours and again 24 hours after treatment of rats with dichloromethane:ethanol (1:1) rose hip extracts. 13 Only one dosage (100 mg/kg) was tested in the Saaby 13 study, and the extraction procedure used (dichloromethane:ethanol extraction) was different to that used by Lattanzio et al 18 Hence, it is difficult to compare the Saaby 13 and Lattanzio et al 18 studies, where the higher dose of plant extract (200 mg/kg) was superior to indomethacin in reducing swelling of the rat paw and the anti-inflammatory effect was evident 30 minutes after administration of the extract, reaching its peak within 1 hour. The anti-inflammatory effect observed in rats by the Lattanzio et al 18 study also differs somewhat from previous data reported by Deliorman Orhan et al, 2 who did not find significant changes in mice paw swellings within the first 180 minutes of administration of the rose hip extract.…”

Section: Studies In Ratsmentioning

confidence: 99%

“…55,56 Aqueous and more lipophilic extractions of rose hip have been tested in animal models with different results. 2,7,13,18 To the best of our knowledge, there are no randomized, placebo controlled clinical studies on extractions from rose hip tested on humans. We found one open uncontrolled observational study in humans with osteoarthritis, who were given an aqueous extraction of rose hip added to collagen hydrolysate.…”

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confidence: 99%

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The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Marstrand¹,

Campbell-Tofte²

2016

BTAT

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Rosa canina fruits (often known as rose hip) have been used in herbal remedies since ancient times. On the basis of anecdotal reports about the effects of rose hip preparations on human health and citations to the same in ancient texts, in vitro and in vivo studies have been conducted that have made it possible to learn about some active ingredients in rose hip, as well as how the component compounds might exert their effects. From such studies, it has been documented that there is a great variation in active ingredients when comparing different rose hip products. Factors which affect the quality and quantity of active ingredients in the rose hip products include the subspecies of the particular R. canina from which the fruits are harvested, the environment during plant growth, time of harvesting, and the amount of seeds and shells/husks incorporated into the preparation. Studies in animals and in humans are of great importance for determining the true bio-effects of rose hip. Such in vivo studies that have only been performed during the last 2 decades indicate that the treatment of patients with different types of joint disease with rose hip powder based on a subspecies of R. canina (Lito) containing a certain galactolipid (GOPO) can alleviate pain, improve daily activity, and even reduce the consumption of regular pain relievers. As several rose hip components have been shown to be anti-inflammatory, it is suggested that anti-inflammatory mechanisms might explain some reductions in symptoms associated with administering rose hip to arthritic conditions. Although the number of publications of randomized and placebo-controlled clinic studies with rose hip is small, the overriding evidence is that the anti-inflammatory effects from administration of rose hip preparations containing both shells and seeds are superior to preparations containing shells alone.

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Section: Studies In Ratsmentioning

confidence: 88%

Section: Studies In Ratsmentioning

confidence: 96%

Section: Studies In Ratsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Marstrand¹,

Campbell-Tofte²

2016

BTAT

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“…Also Colchicum has been used for treatment of gout, joint pain, and inflammation in Iranian Traditional Medicine [42,43]. This herb contains colchicine which is a valuable drug with a narrow therapeutic range.…”

Section: Surinjan (Colchicum Speciosum)mentioning

confidence: 99%

5 Medicinal Plants Used in Iranian Traditional Medicine for Low Back Pain: A Quick Review

Malek¹,

Abbasian²,

Karimi³

et al. 2017

Eur J Exp Bio

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Low back pain (LBP) is a common disorder and a considerable economic burden in industrialized countries. A large number of patients with LBP use complementary and alternative medicine for relief of their pain. Finding effective and suitable therapy is vital for these patients, clinicians and policy makers.Numerous herbal medications have been applied in treatment of LBP. The efficiency of these herbal medicines for the treatment of LBP is not without dispute; therefore, this review was conducted in order to evaluate the effectiveness of the five most widely used traditional therapies for the management of LBP.

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Rosehip

2015

Phytopharmacy

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In vivo anti-inflammatory effect of Rosa canina L. extract

Cited by 90 publications

References 37 publications

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

5 Medicinal Plants Used in Iranian Traditional Medicine for Low Back Pain: A Quick Review

Rosehip

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In vivo anti-inflammatory effect of Rosa canina L. extract

Cited by 90 publications

References 37 publications

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation &ndash; part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation &ndash; part II animal and human studies

5 Medicinal Plants Used in Iranian Traditional Medicine for Low Back Pain: A Quick Review

Rosehip

Contact Info

Product

Resources

About

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies