In vivo antifungal activity of nanoemulsions containing eucalyptus or lemongrass essential oils in murine model of vulvovaginal candidiasis

Gündel, Samanta da Silva; Godoi, Samantha Nunes de; Santos, Roberto Christ Vianna; Silva, Jacqueline Teixeira da; Leite, Liliana Borges de Menezes; Amaral, André Corrêa; Ourique, Aline Ferreira

doi:10.1016/j.jddst.2020.101762

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…In the revised studies only five micro- and nanoemulsion formulations fall within the physiological range of pH values < 4.5 [ 82 , 84 , 86 , 92 , 93 ]. For other reported formulations the pH values were higher and fell within the slightly acidic range, also considered as physiological [ 78 , 85 , 91 , 94 , 95 , 96 , 97 , 102 ]. Some of the formulations pH values exceeded physiological range [ 89 , 90 , 101 ], creating a risk of bacterial infections.…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 98%

“…Furthermore, the essential oils, e.g., tea tree oil, eucalyptus oil, geranium oil, mint essential oil from M. spicata var. virdis and lemongrass oil, can act as multifunctional excipients due to their antimicrobial properties [ 93 , 94 , 95 , 96 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…In contrast, nanoemulsion droplets in the range of 58–211 nm (PDI in the range of 0.20–0.34) have been obtained via ultrasonication preceded by high-speed homogenization (10 000 rpm for 25–30 min) [ 79 , 92 , 98 ]. Examples of nanoemulsions with essential oils manufactured via high-speed homogenization (15,000–17,000 rpm for 20–30 min) enabled to obtain highly homogenous formulations with 68–178 nm oil droplets diameter [ 95 , 96 ]. In nanoemulsion formulation using high-energy methods the surfactants should be mixed with the oil phase prior to the addition of aqueous phase.…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…Optical microscopy is most frequently used for emulsions with droplet sizes in the micrometer range, i.e., macroemulsions, as it only allows the observation of particles larger than 200 nm [ 80 , 81 , 89 , 102 , 104 , 130 ]. The most commonly used method to determine the dispersed phase droplet size of micro- and nanoemulsion-based vaginal dosage forms is the dynamic light scattering (DLS) method, also known as photon correlation spectroscopy, that enables the measurement of droplet sizes in the range from 1 nm to 6 µm [ 74 , 75 , 76 , 77 , 78 , 79 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 98 , 99 , 103 , 105 ]. The accuracy of the obtained results depends on the measurement method and sample preparation, the sample dilution in particular [ 130 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

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Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

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In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Furthermore, high individual anatomical and physiological variability resulting in unsatisfactory therapeutic efficacy of lipophilic active substances requires application of multicompartment drug delivery systems. This manuscript provides an up-to-date comprehensive review of the literature on emulsion-based vaginal dosage forms (EVDF) including macroemulsions, microemulsions, nanoemulsions, multiple emulsions and self-emulsifying drug delivery systems. The first part of the paper discusses (i) the influence of anatomical-physiological conditions on therapeutic efficacy of drug forms after local and systemic administration, (ii) characterization of EVDF components and the manufacturing techniques of these dosage forms and (iii) methods used to evaluate the physicochemical and pharmaceutical properties of emulsion-based vaginal dosage forms. The second part of the paper presents (iv) the results of biological and in vivo studies as well as (v) clinical evaluation of EVDF safety and therapeutic efficacy across different indications.

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Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 98%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

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show abstract

“…However, EOs and their individual constituents are generally unstable in the presence of light, heat, oxygen, and humidity. Also, they are highly volatile and present poor water solubility which required using organic solvents for their dilution and delivery [20][21][22]. Hence, a suitable intervention is necessary to overcome these challenges like using the emulsion technology in which water is used as a preparation medium and a delivery system.…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Cinnamaldehyde Based Emulsion for Phytopathogenic Bacterial Growth Inhibitor

Mohammed

El-Rahman

2020

JAMB

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The formulation plays an essential role in achieving the successful delivery and biological activity of any plant protection products. This study aimed to develop a cinnamaldehyde water-based formulation (oil-in-water emulsion) via a high-shear stirring emulsification method. Cinnamaldehyde emulsion was successfully prepared and characterized using different physicochemical parameters (emulsion stability, persistent foaming, accelerated storage at 54°C for 2 weeks, and stability at 0°Cfor one week, as well as pH, surface tension, flash point, viscosity, and particle size distribution). Also, the antibacterial activity was verified in vitro against some important phytopathogenic bacteria; Erwinia amylovora, Pectobacterium aroidearum, Pseudomonas aeruginosa, and Ralstonia solanacearum using well diffusion method. In addition, the minimum inhibition concentration (MIC) was determined by the twofold dilution method. The results revealed that the prepared formulation showed good storage stability, exhibited non-Newtonian shear-thinning behavior and promising antibacterial activity. The inhibition zones against the tested phytopathogenic bacteria were ranged from 10.3 mm to 52.0 mm. MICs of the prepared formulation were 15.63, 31.25, 62.5, and 15.63 μl/ml against Erwinia amylovora, Pectobacterium aroidearum, Pseudomonas aeruginosa and Ralstonia solanacearum, respectively. Our results provide an environmentally friendly formulation with promising activity to control the agricultural crop disease.

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Eucalyptus Essential Oil Based Nanoemulsions: Preparation and Biological Activities

Rehman,

Hussain,

Muzaffar

et al. 2024

Chemistry & Biodiversity

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Eucalyptus essential oil has remarkable industrial importance and biological properties due to its effectiveness against various diseases, reported throughout human history. Despite the extraordinary bioactivities of essential oil, its applications are limited due to volatility, insolubility in water, and less stability. Formulation of nanoemulsion is the best way to enhance the bio‐efficacy of this essential oil and eliminate the factors responsible for limited application. This review article compiles the information regarding formulation of Eucalyptus essential oil‐based nanoemulsion and their several biological activities and medicinal properties including antibacterial, antifungal, larvicidal, insecticidal, and cytotoxic activities etc. The bio‐efficacy of essential oil‐based nanoemulsion has also been found to be enhanced as compared utilization of essential oil alone. This review can be beneficial for researchers working on medicinal plant‐based natural products, specifically containing Eucalyptus essential oil, to explore new research horizons in this emerging field.

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In vivo antifungal activity of nanoemulsions containing eucalyptus or lemongrass essential oils in murine model of vulvovaginal candidiasis

Cited by 25 publications

References 30 publications

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Eco-Friendly Cinnamaldehyde Based Emulsion for Phytopathogenic Bacterial Growth Inhibitor

Eucalyptus Essential Oil Based Nanoemulsions: Preparation and Biological Activities

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