2017
DOI: 10.1016/j.carbpol.2017.06.040
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In vivo antihyperlipidemic and antioxidant activity of porphyran in hyperlipidemic mice

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Cited by 54 publications
(28 citation statements)
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“…A previous study demonstrated porphyrans' antioxidant activity in mice by preventing hyperlipidemia [166].…”
Section: Carrageenanmentioning
confidence: 96%
“…A previous study demonstrated porphyrans' antioxidant activity in mice by preventing hyperlipidemia [166].…”
Section: Carrageenanmentioning
confidence: 96%
“…The increase in ROS is often accompanied by an increase in the levels of TC and LDL-C, and ROS can also convert the excess LDL-C into oxidized LDL-C and promote the development of metabolic syndrome [111]. A study has shown that porphyran extracted from Porphyra haitanensis significantly increased the levels of antioxidant enzymes SOD and GSH-Px in the liver of hyperlipidemia mice, thereby inhibiting the increase of plasma HDL-C mediated by oxidative stress [112]. In addition, studies disclosed that red algal polysaccharides can alleviate cell damage and aging [113,114], but the possible protective mechanisms of red algal polysaccharides on cell damage are still unclear.…”
Section: Red Algal Polysaccharidesmentioning
confidence: 99%
“…Porphyra , which is an important food source worldwide, is nutritious seaweed that is abundant in proteins, polysaccharides, vitamins, and minerals [ 12 ]. Porphyran, with a linear backbone of alternating 3-linked β- d -galactose and 4-linked α- l -galactose-6-sulfate or 3,6-anhydro-α- l -galactose (3,6-AG) units [ 13 ], is a natural compound with various bioactivities, including anti-hyperlipidemia [ 14 ], anti-oxidative [ 15 ], and anti-inflammatory effects [ 16 ]. Wang et al found that acetylated and phosphorylated porphyran antagonized the weak toxicity of 6-OHDA on MES23.5 dopaminergic cells, possessing minor neuroprotective effects that were independent of mitochondrial restoration.…”
Section: Introductionmentioning
confidence: 99%