In vivo antimetastatic and immunomodulating activity of phytomix-40

Бочарова, О. А.; Карпова, Р. В.; Golubeva, V. A.; Filippova, T. G.; Kasatkina, N. N.; Baryshnikov, A. Yu.

doi:10.1007/bf02433190

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…MPhA also contributed to both spontaneous and mitogen‐induced proliferative activity of T‐lymphocytes. Thus, the antimetastatic properties of MPhA were revealed which correlates with the immunomodulatory effect on the T‐cell immunity and increased survival of animals [64] …”

Section: Resultsmentioning

confidence: 99%

“…Thus, the antimetastatic properties of MPhA were revealed which correlates with the immunomodulatory effect on the T-cell immunity and increased survival of animals. [64] MPhA also showed radioprotective properties in mice and dogs under conditions of acute and prolonged gamma irradiation. The animals' lifespan increased by 80 % (mice) and 40 % (dogs) with the best peripheral blood parameters.…”

Section: In Vivo Studies (On Animals)mentioning

confidence: 91%

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Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Бочарова¹,

Ионов

Казеев³

et al. 2022

Molecular Informatics

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Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex pathological processes of different etiology. Extracts of medicinal plants (EMP) containing multiple phytocomponents are widely used in traditional medicines for multifactorial disorders' treatment. Experimental studies of pharmacological potential for multicomponent compositions are quite expensive and time-consuming. In silico evaluation of EMP the pharmacological potential may provide the basis for selecting the most promising directions of testing and for identifying potential additive/ synergistic effects. Multiphytoadaptogen (MPhA) containing 70 major phytocomponents of different chemical classes from 40 medicinal plant extracts has been studied in vitro, in vivo and in clinical researches. Antiproliferative and anti-tumor activities have been shown against some tumors as well as evidencebased therapeutic effects against age-related pathologies. In addition, the neuroprotective, antioxidant, antimutagenic, radioprotective, and immunomodulatory effects of MPhA were confirmed. Analysis of the PASS profiles of the biological activity of MPhA phytocomponents showed that most of the predicted anti-tumor and anti-metastatic effects were consistent with the results of laboratory and clinical studies. Antimutagenic, immunomodulatory, radioprotective, neuroprotective and anti-Parkinsonian effects were also predicted for most of the phytocomponents. Effects associated with positive effects on the male and female reproductive systems have been identified too. Thus, PASS and PharmaExpert can be used to evaluate the pharmacological potential of complex pharmaceutical compositions containing natural products Keywords: natural products • multiphytoadaptogen • pharmacological potential • PASS • PharmaExpert • in silico estimation • in vitro and in vivo validation • clinical studies

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Section: Resultsmentioning

confidence: 99%

Section: In Vivo Studies (On Animals)mentioning

confidence: 91%

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Бочарова¹,

Ионов

Казеев³

et al. 2022

Molecular Informatics

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“…Comparative studies of in vitro effects of the plant extracts (phytopreparation components and their combinations) on proliferative activity of CaOv cells allowed creating an optimal composition. Experimental studies of FM-40 were carried out [3,6,8].…”

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confidence: 99%

Leukoplakia of oral mucosa: Pathogenesis and possible correction with phytoadaptogen

Бочарова¹,

Pozharitskaya²,

Chekalina³

et al. 2004

Bull Exp Biol Med

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Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the pathological focus and complete epithelialization of erosive surfaces. The phytopreparation exhibited adaptogenic effects normalizing the immune and IFN status and improving the state of adaptation systems in the body.

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A Potential Method for Standardization of Multiphytoadaptogen: Tandem Mass Spectrometry for Analysis of Biologically Active Substances from Rhodiola rosea

et al. 2022

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In vivo antimetastatic and immunomodulating activity of phytomix-40

Cited by 3 publications

References 6 publications

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Leukoplakia of oral mucosa: Pathogenesis and possible correction with phytoadaptogen

A Potential Method for Standardization of Multiphytoadaptogen: Tandem Mass Spectrometry for Analysis of Biologically Active Substances from Rhodiola rosea

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