In vivo antioxidant activities of Curcuma longa and Curcuma xanthorrhiza: a review

Lukitaningsih, Endang; Rohman, Abdul; Rafi, Mohamad; Nurrulhidayah, A.F.; Windarsih, Anjar

doi:10.26656/fr.2017.4(1).172

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…Among herbal medicines components, Curcuma species including C. longa (turmeric), C. xanthorrhiza (Java Turmeric), and C. manga have been widely applied as medicinal plants for herbal or traditional medicine purposes [7]. These Curcumas have been reported to have some biological effects which are beneficial to human health including antioxidant, anticancer anti-inflammatory, hepatoprotector, cardioprotector, antibacterial activities, and wound healing [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Metabolite Fingerprinting Using 1H-NMR Spectroscopy and Chemometrics for Classification of Three Curcuma Species from Different Origins

et al. 2021

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Curcuma longa, Curcuma xanthorrhiza, and Curcuma manga have been widely used for herbal or traditional medicine purposes. It was reported that turmeric plants provided several biological activities such as antioxidant, anti-inflammatory, hepatoprotector, cardioprotector, and anticancer activities. Authentication of the Curcuma species is important to ensure its authenticity and to avoid adulteration practices. Plants from different origins will have different metabolite compositions because metabolites are affected by soil nutrition, climate, temperature, and humidity. 1H-NMR spectroscopy, principal component analysis (PCA), and orthogonal projections to latent structures-discriminant analysis (OPLS-DA) were used for authentication of C. longa, C. xanthorrhiza, and C. manga from seven different origins in Indonesia. From the 1H-NMR analysis it was obtained that 14 metabolites were responsible for generating classification model such as curcumin, demethoxycurcumin, alanine, methionine, threonine, lysine, alpha-glucose, beta-glucose, sucrose, alpha-fructose, beta-fructose, fumaric acid, tyrosine, and formate. Both PCA and OPLS-DA model demonstrated goodness of fit (R2 value more than 0.8) and good predictivity (Q2 value more than 0.45). All OPLS-DA models were validated by assessing the permutation test results with high value of original R2 and Q2. It can be concluded that metabolite fingerprinting using 1H-NMR spectroscopy and chemometrics provide a powerful tool for authentication of herbal and medicinal plants.

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Section: Introductionmentioning

confidence: 99%

Metabolite Fingerprinting Using 1H-NMR Spectroscopy and Chemometrics for Classification of Three Curcuma Species from Different Origins

et al. 2021

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“…The antioxidant activity of curcuma extract in vitro has been proven by the DPPH method (Widyastuti et al 2020). Several parameters observed in the in vivo antioxidant activity test of aqueous black tea and curcuma extracts were SOD (Superoxide Dismutase) activity, GSH-Px (Gluthatione Peroxidase) activity, and MDA (Malondialdehyde) levels (Lukitaningsih et al 2020;Sun et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase Enzyme Inhibitor and Antioxidant Activities from A Mixture Extracts of Black Tea, Red Betel, Cinnamon and Curcuma

2023

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Alzheimer's Disease (AD) is one of the consequences of impaired functioning of acetylcholine which can be hydrolyzed by the enzyme acetylcholinesterase. Alzheimer's treatment is carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that can slow the progression of Alzheimer's, but their use can cause excessive side effects. The use of herbal plants as a cure for Alzheimer's disease has been proven to be safer and does not cause excessive side effects. Herbal plants that can be used and developed are black tea, red betel, curcuma, and cinnamon. This study determined that extracts of black tea, red betel leaf, curcuma, and cinnamon's formula have the best antioxidant activity and level of inhibition of the acetylcholinesterase enzyme. F1 (cinnamon), F5 (cinnamon, black tea, red betel, and curcuma), F6 (cinnamon and black tea), and F11 (cinnamon, black tea, and curcuma) were the best formulations in each type of sample based on inhibitory AChE enzymes and antioxidants activity. F1 (cinnamon) is the most effective extract out of all formulations analyzed in this study. Keywords: Acetylcholinesterase; Alzheimer; Black Tea; Cinnamon; Red Betel; Curcuma

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“…The most active and abundant compounds extracted from C. xanthorrhiza are essential oil and curcumin . As a natural polyphenol, curcumin is more active as an antioxidant than vitamin E and beta carotene .…”

Section: Introductionmentioning

confidence: 99%

Extraction Process Optimization of Curcumin from Curcuma xanthorrhiza Roxb. with Supercritical Carbon Dioxide Using Ethanol as a Cosolvent

Sutarsi,

Jati,

Wiradiestia

et al. 2023

ACS Omega

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Curcuma xanthorrhiza Roxb., known as temulawak, Javanese ginger, or Javanese turmeric, is a plant species belonging to the ginger family. This plant originated in Indonesia, more specifically on Java Island, and is usually used as medicine. It contains a high amount of a phenolic compound, namely, curcumin. A supercritical carbon dioxide extraction technique was employed to extract curcumin from C. xanthorrhiza. The objective of this work was to investigate the effects of temperature, pressure, and CO 2 flow rate on the extraction yield and curcumin recovery from C. xanthorrhiza, which was extracted using supercritical carbon dioxide and ethanol as a cosolvent. The Box−Behnken design (BBD) experimental design and response surface methodology were used to optimize the extraction yield and curcumin recovery. The extraction conditions at a temperature of 40 °C, a pressure of 25 MPa, and a CO 2 flow rate of 5.34 mL/min produced the optimum extraction yield of 10.4% and curcumin recovery of 3.2%. From Fourier transform infrared analysis, although the physical−chemical structure in the residue of the starting material was almost similar, the quantity of all functional groups in the residue decreased from the starting material. From scanning electron microscopy analysis, it was confirmed that the cell was broken due to the high-pressure effect, so that the extraction process runs easily.

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In vivo antioxidant activities of Curcuma longa and Curcuma xanthorrhiza: a review

Cited by 22 publications

References 29 publications

Metabolite Fingerprinting Using 1H-NMR Spectroscopy and Chemometrics for Classification of Three Curcuma Species from Different Origins

Metabolite Fingerprinting Using 1H-NMR Spectroscopy and Chemometrics for Classification of Three Curcuma Species from Different Origins

Acetylcholinesterase Enzyme Inhibitor and Antioxidant Activities from A Mixture Extracts of Black Tea, Red Betel, Cinnamon and Curcuma

Extraction Process Optimization of Curcumin from Curcuma xanthorrhiza Roxb. with Supercritical Carbon Dioxide Using Ethanol as a Cosolvent

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