In Vivo Antioxidant Activity of Procyanidin-Rich Extracts from Grape Seed and Pine (Pinus Maritima) Bark in Rats

Busserolles, Jérôme; Gueux, Elyett; Bałasińska, B.; Piriou, Yannick; Rock, Edmond; Rayssiguier, Yves; Mazur, Andrzej

doi:10.1024/0300-9831.76.1.22

Cited by 38 publications

(26 citation statements)

References 18 publications

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“…These flavan-3-ols are thought to stimulate a pseudo laminar sheer stress response in endothelial cells that aids to repair endothelial function [90]. High degree of polymerization pine bark extract fed to rats at 500 mg/kg body weight provides greater total antioxidant activity than lower degree of polymerization pine bark extract [91].…”

Section: Herbal Remediesmentioning

confidence: 99%

Flavan‐3‐ols: Nature, occurrence and biological activity

Aron

Kennedy²

2008

Molecular Nutrition Food Res

655

491

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Representing the most common flavonoid consumed in the American diet, the flavan-3-ols and their polymeric condensation products, the proanthocyanidins, are regarded as functional ingredients in various beverages, whole and processed foods, herbal remedies and supplements. Their presence in food affects food quality parameters such as astringency, bitterness, sourness, sweetness, salivary viscosity, aroma, and color formation. The ability of flavan-3-ols to aid food functionality has also been established in terms of microbial stability, foamability, oxidative stability, and heat stability. While some foods only contain monomeric flavan-3-ols [(-)-epicatechin predominates] and dimeric proanthocyanidins, most foods contain oligomers of degree of polymerization values ranging from 1-10 or greater than 10. Flavan-3-ols have been reported to exhibit several health beneficial effects by acting as antioxidant, anticarcinogen, cardiopreventive, antimicrobial, anti-viral, and neuro-protective agents. This review summarizes the distribution and health effects of these compounds.

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Section: Herbal Remediesmentioning

confidence: 99%

Flavan‐3‐ols: Nature, occurrence and biological activity

Aron

Kennedy²

2008

Molecular Nutrition Food Res

655

491

View full text Add to dashboard Cite

show abstract

“…Conversely, PBE treated group showed reversion of all these biochemical indices, as well as histopathological alterations that were induced by ischemia and reperfusion I/R. Busserolles et al (2006) studied the in vivo effects of procyanidin rich-extract on oxidative stress in rats in two conditions, i.e. rats were given diet supplemented with grape extract (GE) and pine extract (PE) either for a period of 8 weeks or given single dose only to observe the postprandial effect.…”

Section: Protective Effect Against I/r-induced Oxidationmentioning

confidence: 99%

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Maimoona

Naeem

Saddiqe

et al. 2011

Journal of Ethnopharmacology

151

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“…Procyanidins, one of the natural chemopreventive agents, are the most abundant polyphenols in fruits, vegetables, cereals, green tea, nuts, seeds, bark and food grains and might decrease the risk of chronic diseases such as cardiovascular and cancers [4–10]. Procyanidins have received a great deal of attention over several decades, and many biological activities such as anti-oxidant [11,12], anti-mutagenic [13], anti-cytotoxic [6], anti-inflammatory [14] and cardioprotective effects [15] have been identified. Furthermore, procyanidins have been reported to inhibit lipid peroxidation [16], platelet aggregation [17] and to modulate the activity of disease-related molecular targets including COX-2 and nuclear factor κB (NF-κB) [18].…”

Section: Introductionmentioning

confidence: 99%

Procyanidins from Wild Grape (Vitis amurensis) Seeds Regulate ARE-Mediated Enzyme Expression via Nrf2 Coupled with p38 and PI3K/Akt Pathway in HepG2 Cells

Bak

Jun

Jeong

2012

IJMS

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Procyanidins, polymers of flavan-3-ol units, have been reported to exhibit many beneficial health effects such as antioxidant and anti-carcinogenic effects. In this study, we investigated the cancer chemopreventive properties of procyanidins from wild grape (Vitis amurensis) seeds in particular their roles in inducing phase II detoxifying/antioxidant enzymes as well as in modulating the upstream kinases. Ethanolic extract of V. amurensis seeds was fractionated with a series of organic solvents and finally separated into six fractions, F1–F6. Chemical properties of the procyanidins were analyzed by vanillin assay, BuOH-HCl test, and depolymerization with phloroglucinol followed by LC/MS analysis. The F5 had the highest procyanidin content among all the fractions and strongly induced the reporter activity of antioxidant response element as well as the protein expression of nuclear factor E2-related factor (Nrf2) in HepG2 human hepatocarcinoma cells. The procyanidin-rich F5 also strongly induced the expression of the phase II detoxifying and antioxidant enzymes such as NAD(P)H:quinone oxidoreductase1 and hemeoxygenase1. Phosphorylations of the upstream kinases such as MAPKs and PI3K/Akt were significantly increased by treatment with procyanidin fraction. In addition, the procyanidin-mediated Nrf2 expression was partly attenuated by PI3K inhibitor LY294002, and almost completely by p38 inhibitor SB202190, but neither by JNK inhibitor SP600125 nor by MEK1/2 inhibitor U0126. Taken together, the procyanidins from wild grape seeds could be used as a potential natural chemopreventive agent through Nrf2/ARE-mediated phase II detoxifying/antioxidant enzymes induction via p38 and PI3K/Akt pathway.

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In Vivo Antioxidant Activity of Procyanidin-Rich Extracts from Grape Seed and Pine (Pinus Maritima) Bark in Rats

Abstract: The results of the present experiment constitute positive evidence for an in vivo antioxidant effect at the plasma level of procyanidin-containing plant extracts.

Cited by 38 publications

References 18 publications

Flavan‐3‐ols: Nature, occurrence and biological activity

Flavan‐3‐ols: Nature, occurrence and biological activity

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Procyanidins from Wild Grape (Vitis amurensis) Seeds Regulate ARE-Mediated Enzyme Expression via Nrf2 Coupled with p38 and PI3K/Akt Pathway in HepG2 Cells

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