In–Vivo Antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats

Jain, Sachin; Jain, Dinesh Kumar; Balekar, Neelam

doi:10.1016/s2221-1691(12)60306-2

Cited by 22 publications

(17 citation statements)

References 9 publications

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“…The kinetics of discoloration of the emulsion in the presence and the absence of antioxidant is measured at 490 nm at intervals over 48 hours (1,2,3,4,6,24, and 48 hrs) of incubation at ambient temperature and in the darkness.…”

Section: Dpph Radical Scavenging Activity Of Plant Extractmentioning

confidence: 99%

“…It is also a good remedy for headaches and for minor respiratory infections and a powerful stimulant to the uterine muscle encouraging menstruation. [4] It can be used externally to relieve rheumatic conditions including gout. [3] However, additional research is necessary to evaluate the practical values of therapeutic application.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Current natural medicine also uses it as anti-inflammatory drug and as a disinfectant. [4] Currently, chamomile is used to treat all the disorders where the spasm occupies a significant place, such as in the case of painful digestive spasms and for dysmenorrhoea. [6] Mentha pulegium L. was described as a potential source of phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols and antioxidant properties of extracts from Mentha pulegium L. and Matricaria chamomilla L.

Khennouf¹,

Dalila²,

Djidel³

et al. 2013

Phcog Commn

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Introduction: Mentha pulegium L. and Matricaria chamomilla L. are used in the Algerian folk medicine. This study was carried out to determine the antioxidant activity of these plants and their polyphenols contents. Methods:The antioxidant capacity of the plant extracts was determined by the scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and β-carotene/linoleic acid model system. Total phenolic content in these extracts were determined using Folin-Ciocalteu's reagent. Results: The methanolic extract (MeE) of Mentha pulegium L. showed the highest yield of extraction (14.4%). Whereas, the aqueous extract (AqE) of Matricaria chamomilla L. had the highest yield (18.56%) from total extracted plant material. Moreover, the ethyl acetate extract of Mentha pulegium L. contains high amount of total polyphenols; tannins and flavonoids (191.99 µg gallic acid equivalent/g dry extract; 265.33 µg tannic acid equivalent/g dry extract; 110.37 µg quercetin equivalent/g dry extract; 151.11 µg rutin equivalent/g dry extract) respectively. This extract possessed high antioxidant activity (IC 50 =0.017 mg/ml) in the DPPH assay whilst the chloroformic extract (ChE) is more efficient in the β carotene/linoleic acid assay with (61.07%). The ChE of M. chamomilla contains the higher value of flavonoids (197.43 µg quercetin equivalent/g) and total polyphenols were abundant in MeE. The ethyl acetate extract of this plant had the highest antioxidant activity (IC 50 = 0.0111 mg/ml) in the DPPH assay, while chloroformic extract shows appreciable inhibition value (37.15%) in the β carotene/linoleic acid assay. Conclusion: These results provide useful information about the utilization of these plants as natural antioxidants in food and in folk medicine.

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Section: Dpph Radical Scavenging Activity Of Plant Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polyphenols and antioxidant properties of extracts from Mentha pulegium L. and Matricaria chamomilla L.

Khennouf¹,

Dalila²,

Djidel³

et al. 2013

Phcog Commn

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“…For example, certain enzymes in the body, such as SOD, CAT, GPx and GSH, work with another chemical to transfer free radical into harmless molecules. [41] Oxidative stress is a condition of reduction in antioxidative enzymes such as SOD, CAT, GPx, and GSH S-transferases. [42] The antioxidant enzymes SOD and CAT play an important role in reducing cellular stress.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Kumaran

2017

AJP

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Aim: In the present study, the synthesis of silver nanoparticle from ethanolic extraction of Abutilon indicum (Link) and its anti-inflammatory & antioxidant properties were studied. The bioactive compounds from Abutilon indicum were identified by gas chromatography and mass spectroscopy. The AgNPs synthesis was done using the ethanolic solution of A. indicum extract and silver nitrate. Materials and Methods: The AgNPs were characterized using ultraviolet (UV)-spectroscopic analysis, high-resolution transmission electron microscopy (HRTEM), and Fourier transform infrared spectroscopy (FTIR) analysis. The anti-inflammatory and antioxidants assays were followed by the standard methods. The mice bioassay study was conducted using doses of 50, 100, 150, and 200 mg/kg bw. Results: The presence of bioactive compounds from A. indicum is dodecanoic acid (8.846), octadecanoic acid (9.608), nonanoic acid (12.258), N-hexadecanoic acid (14.222), ethanol, 2-bromo (16.985), dibutyl phthalate (17.729), phytol (19.671), and diisooctyl phthalate (23.272). UV-visible spectral analysis shows a maximum absorption peak at 421.00 nm. The FTIR spectra of AgNPs exhibited prominent peaks represents such as alcohols, phenols, alkynes, aromatics, aldehydes, alkenes, aromatics, aliphatic amines, 1° and 2° amines, and alkyl halides. The HRTEM analysis of the synthesized AgNPs clearly showed the clustered and irregular shapes, mostly aggregated and having the size of 20 nm. The maximum inhibition of edema 39.49% was found in ethanolic extraction of A. indicum (200 mg/kg bw) and AgNPs of A. indicum (100 mg/kg bw) showed 55.98% at the end of 3 h. A significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, vitamin-C and vitamin-E was observed in tissue of inflammation in rats on treatment with 100 mg/kg body weight of A. indicum extract and compared with standard and control groups. Conclusion: This study indicates the AgNPs synthesized A. indicum possesses anti-inflammatory and antioxidant potential which may be used for therapeutic purposes mainly in the prevention of oxidative damage that occurs during inflammation.

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“…Indeed, it was previously shown that cytoskeletal proteins and integral membrane proteins are responsible for maintaining of erythrocytes morphology (Sato et al 1986. Both AE and EE from M. pulegium were found also to produce protective effect against t-BHP-induced TBARS production, which may be attributed to its antioxidant potential (Jain et al 2012, Brahmi et al 2017. Accordingly, it is reasonable to conclude that both extracts from this plant protects erythrocytes from lipid damage cased by t-BHP.…”

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confidence: 81%

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

Bianchini

Galvão

Tamborena

et al. 2017

An. Acad. Bras. Ciênc.

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Mentha pulegium (Lamiaceae) tea has been used as a traditional medicine; however, the modulatory effect of M. pulegium extracts on damage to human erythrocytes associated to t-butyl hydroperoxide (t-BHP) exposure remains to be investigated. Accordingly, we perform this study in order to test the hypothesis that aqueous and ethanolic extracts of M. pulegium could modulate the hemolysis associated to t-BHP exposure, non-protein thiol (NPSH) oxidation and lipid peroxidation (measured as thiobarbituric acid reactive substances -TBARS) in human erythrocytes. Samples were co-incubated with t-BHP (4 mmol/L) and/or aqueous or ethanolic extracts (10-1000 mg/mL) during 120 min to further analysis. We found that both extracts, when associated to t-BHP, potentiate NPSH oxidation and hemolysis. Moreover, both extracts significantly prevents against t-BHP-induced TBARS production. A significant correlation among hemolysis and NPSH levels was found. Taking together, our data points that the association of M. pulegium extracts with t-BHP culminates in toxic effect to exposed erythrocytes, besides its protective effect against t-BHP-induced TBARS production. So, we infer that the use of this extract may exert negative effect during painful crisis in sickle cell anemia. However, more studies are still necessary to better investigate/ understand the mechanism(s) involved in the toxic effect resultant from this association.

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In–Vivo Antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats

Cited by 22 publications

References 9 publications

Polyphenols and antioxidant properties of extracts from Mentha pulegium L. and Matricaria chamomilla L.

Polyphenols and antioxidant properties of extracts from Mentha pulegium L. and Matricaria chamomilla L.

Untitled

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

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