In vivo antiplatelet effect of intravenous alum in rabbits

Abstract

Traditionally known as a haemostatic agent, alum shows a paradoxical effect of increased prothrombin and partial thromboplastin times. This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. Collagen-induced platelet aggregation was significantly reduced after alum injection. Bleeding time from an ear puncture in 8 rabbits was also significantly prolonged after intravenous alum injection. These results suggest that the use of alum as an oral antiplatelet drug could be explored further, taking into account possible side-effects especially in renal compromised patients

Evaluation of Cytotoxic Potential of Classical Siddha Medicine Padikara Parpam in Human Monocytic Leukemic Cell Lines (THP-1)

“…13 This makes it a suitable candidate for treating intravescicular hemorrhage due to bladder and prostate carcinoma. 14 There are established studies of Alum proving its effects in tumor suppression by enhancing cell mediated responses. A study on Balb/c mice models induced with H22 Hepatocarcinoma followed by IP injections of alum had shown significant tumor growth reduction and increased cytokine profiles like IL-1β and TNF-α.…”