2018
DOI: 10.1002/jat.3656
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In vivo assay of the potential gadolinium‐induced toxicity for sensory hair cells using a zebrafish animal model

Abstract: Recently, intratympanic injection of gadolinium-based contrast agent (GdC) is growing in use to visualize the endolymphatic hydrops. Although GdC has been quite safely used over 20 years through intravenous injection, the biological influence of GdC on sensory hair cells needs to be thoroughly assessed for wider clinical application of it through intratympanic injection. In this in vivo experimental study, the summated number of sensory hair cells (SO1, SO2, O1 and OC1 neuromasts) showed a steep decrease in th… Show more

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Cited by 7 publications
(9 citation statements)
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“…The first concern is the potential for toxicity of GBCAs. The mechanisms of GBCAs toxicity is gradually revealing from recent studies [6][7][8] . Rogosnitzky & Branch 6 review gadolinium accumulation in various tissues of patients without renal impairment, including bone, brain, and kidneys.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The first concern is the potential for toxicity of GBCAs. The mechanisms of GBCAs toxicity is gradually revealing from recent studies [6][7][8] . Rogosnitzky & Branch 6 review gadolinium accumulation in various tissues of patients without renal impairment, including bone, brain, and kidneys.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the contrast agent administration will be considered carefully, even if normal serum creatinine levels are maintained. Rah et al 7 state that intratympanic contrast injection can cause local toxicity in animal models. However, it may not be likely that a GBCA will lead to hair cell toxicity, as the estimated concentration in the inner ear after clinically tried intratympanic injection is far more diluted.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Another potential field of application is the detection of ototoxicity in environmental samples, contamination of which could be relevant for both human health and aquatic habitats. Heavy metals like copper, cadmium or gadolinium are known to be toxic to zebrafish hair cells ( Hernández et al, 2006 ; Linbo et al, 2009 ; Rah et al, 2018 ; Schmid et al, 2020 ). Other chemical compounds that have been found to induce hair cell damage in zebrafish larvae include: pesticides ( Nasri et al, 2016 ; Wu et al, 2021 ), bisphenol A, a well-known endocrine disruptor ( Hayashi et al, 2015 ), tris (1-chloro-2-propyl) phosphate, a flame retardant ( Xia et al, 2021 ) or urban waters ( McIntyre et al, 2014 ; Young et al, 2018 ).…”
Section: Screening For Potential Ototoxinsmentioning
confidence: 99%
“…1,3 Zebrafish have neuromasts, which are composed of clusters of hair cells, on the surface of their lateral line system. [6][7][8] Morphology and functions of hair cells of zebrafish are similar to those of the mammalian inner ear. 6 Furthermore, zebrafish has been used for investigating damage to hair cells after exposure to ototoxic chemicals owing to the easy assessment of damage to hair cells.…”
Section: Introductionmentioning
confidence: 99%