In vivo assessment of a novel biodegradable ureteral stent

Barros, Alexandre A.; Oliveira, Carlos; ribeiro, Ana J.; Autorino, Riccardo; Reis, Rui L.; Duarte, Ana Rita C.; Lima, Estêvão

doi:10.1007/s00345-017-2124-3

Cited by 49 publications

(38 citation statements)

References 17 publications

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“…In this review, the term device‐associated UTI designates both these types of devices. The following clinical needs have been identified: a) better methods for diagnosing and quantifying microbial colonization, b) development of antimicrobial agents that can disrupt and/or prevent formation of biofilms including crystalline biofilms, c) development of surface coatings that resist and/or reduce microbial adhesion and colonization, as well as d) reducing the use of conventional antimicrobial agents in order to reduce development of resistance …”

Section: Device‐associated Urinary Tract Infectionsmentioning

confidence: 99%

Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

Ramstedt

Ribeiro

Bujdáková

et al. 2019

Macromolecular Bioscience

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Device-Associated Urinary Tract InfectionsUrological devices are divided into several different market segments managing, for example, urinary incontinence, urinary stones, treatment of prostate hyperplasia or cancer, and erectile dysfunction. Devices aimed to manage urinary incontinence or maintain the ureter or urethra open and unobstructed, include ureteral stents for the upper urinary tract, urethral stents for the lower urinary tract, and urinary catheters. The focus of this paper is on catheter-and ureteral stent-associated UTI (Figure 1) as these are the major device groups and give rise to large numbers of infections worldwide. [10] In this review,

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Section: Device‐associated Urinary Tract Infectionsmentioning

confidence: 99%

Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

Ramstedt

Ribeiro

Bujdáková

et al. 2019

Macromolecular Bioscience

Self Cite

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“…[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] Novel biodegradable ureteral stents were manufactured using Uriprene to improve urine drainage, provide good biocompatibility and avoid traditional removal. 37 The issues with these stents included axial rigidity leading to difficult placement, non-uniform degradation and the biodegrading time of 10 weeks which was longer than typical indwelling stents. The potential disadvantages are the complete degradation over a few days which limits the use for very short-term stenting.…”

Section: Variations In Stent Removalmentioning

confidence: 99%

“…However, studies by Barros et al and Soria et al have demonstrated degradation in a predictable and controlled fashion with no obstructive fragments. 37,39 Certain stents have strings attached to help removal and some have baskets to improve the passageway for small stones and stop bigger stones' migration through the ureter. 4,38 There are other stents made from biodegradable/bioabsorbable metal mesh and some have polymeric flap valves to reduce reflux.…”

Section: Variations In Stent Removalmentioning

confidence: 99%

<p>Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents</p>

Ramachandra

Mosayyebi²,

Carugo³

et al. 2020

RRU

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Ureteric stents have played a vital role in relieving urinary obstruction in many urological conditions. Although they are extremely successful, stents have been associated with complications and reduced patients' health-related quality of life (HRQoL). There are many factors that may affect the quality and longevity of stents. In this review, we have highlighted the journey and innovation of ureteric stents through the modern day. A literature review was conducted to identify relevant articles over the last 20 years. There is a plethora of evidence with various indications for the use of ureteral stents and how they affect QoL. There is still ongoing research to develop the ideal stent with reduced encrustation, one that resists infection and is also comfortable for the patients. Stents made from metal alloys, polymers and biodegradable materials have unique properties in their own right but also have certain deficiencies. These have been discussed along with an overview of newly developed stents. Certain pharmacological adjuncts have also been highlighted that may be useful to improve patient's tolerance to stents. In summary, this paper describes the features of the different types of stents and the problems that are frequently encountered, including effect on patients' HRQoL and financial burden to healthcare providers.

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“…The in vivo degraded experiment indicated that this stent exhibited the fastest biodegradation rate than the control group. Moreover, the stent could effectively reduce the bacterial adhesion and showed excellent biocompatibility properties (Barros et al, 2018).…”

Section: Natural Origin Polymersmentioning

confidence: 99%

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

et al. 2020

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Drug eluting ureteral stent is an effective means for local drug delivery to the urinary tract. It can potentially solve a variety of upper urinary tract problems, such as stent-related urinary tract infections and discomfort, ureteral stricture, and neoplastic diseases. However, the release of drug elutes on the surface of biostable stents is unsustainable and uncontrollable. With the development of biomaterial science, the emergence of biodegradable ureteral stents (BUSs) provides a new approach for local drug delivery in the urinary tract. The drugs can be continuously released in a controlled manner from a drug-eluting BUS, when the stent degrades. Especially for the delivery of anti-tumor drugs, the stents can obviously improve the therapeutic effectiveness of the drugs by prolonging the contact duration of the drug and tumor cells. In addition, a secondary stent removal procedure can be avoided. The purpose of this review article is to provide an overview of anti-tumor drug-eluting BUSs and discuss the biomaterials and drug delivery systems of BUS that are currently being developed to deliver anti-tumor drugs for upper tract urothelial carcinoma.

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In vivo assessment of a novel biodegradable ureteral stent

Cited by 49 publications

References 17 publications

Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

<p>Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents</p>

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

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