In Vivo Assessment of Architecture and Micro-Finite Element Analysis Derived Indices of Mechanical Properties of Trabecular Bone in the Radius

Newitt, David; Majumdar, Sharmila; Rietbergen, van B Bert; Ingersleben, Gabriel von; Harris, S. T.; Genant, Harry K.; Chesnut, Charles H.; Garnero, Patrick; MacDonald, Brian

doi:10.1007/s198-002-8332-0

Cited by 83 publications

(15 citation statements)

References 20 publications

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“…Importantly, a strong correlation was found between all scalar architectural parameters (porosity, Tb.N, Tb.Th, and Tb.Sp) and vBMD, but no statistical correlation was found between vBMD and the fabric tensor components. This result is in agreement with the low correlation between aBMD and MIL components reported by Newitt et al, (65) at the ultradistal wrist, and at the calcaneum by Mittra et al, (60) . Therefore, only fabric components seem to explain data variance on acoustic anisotropy that cannot be explained by vBMD.…”

Section: Discussionsupporting

confidence: 93%

Microarchitecture and bone quality in the human calcaneus: Local variations of fabric anisotropy

Souzanchi¹,

Palacio-Mancheno²,

Borisov³

et al. 2012

Journal of Bone and Mineral Research

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The local variability of microarchitecture of human trabecular calcaneus bone is investigated using high resolution microCT scanning. The fabric tensor is employed as the measure of the microarchitecture of the pore structure of a porous medium. It is hypothesized that a fabric tensor-dependent poroelastic ultrasound approach will more effectively predict the data variance than will porosity alone. The specific aims of the present study are i) to quantify the morphology and local anisotropy of the calcaneus microarchitecture with respect to anatomical directions, ii) to determine the interdependence, or lack thereof, of microarchitecture parameters, fabric, and volumetric bone mineral density (vBMD), and iii) to determine the relative ability of vBMD and fabric measurements in evaluating the variance in ultrasound wave velocity measurements along orthogonal directions in the human calcaneus. Our results show that the microarchitecture in the analyzed regions of human calcanei is anisotropic, with a preferred alignment along the posterior-anterior direction. Strong correlation was found between most scalar architectural parameters and vBMD. However, no statistical correlation was found between vBMD and the fabric components, the measures of the pore microstructure orientation. Therefore, among the parameters usually considered for cancellous bone (i.e., classic histomorphometric parameters such as porosity, trabecular thickness, number and separation), only fabric components explain the data variance that cannot be explained by vBMD, a global mass measurement, which lacks the sensitivity and selectivity to distinguish osteoporotic from healthy subjects because it is insensitive to directional changes in bone architecture. This study demonstrates that a multi-directional, fabric-dependent poroelastic ultrasound approach has the capability of characterizing anisotropic bone properties (bone quality) beyond bone mass, and could help to better understand anisotropic changes in bone architecture using ultrasound.

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Section: Discussionsupporting

confidence: 93%

Microarchitecture and bone quality in the human calcaneus: Local variations of fabric anisotropy

Souzanchi¹,

Palacio-Mancheno²,

Borisov³

et al. 2012

Journal of Bone and Mineral Research

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“…The coronal 3D FISP images were quantitatively analyzed using CalcDCN software; this analysis tool was developed and validated at the University of California, San Francisco 31, 33–40 . Briefly, the images were analyzed as follows.…”

Section: Methodsmentioning

confidence: 99%

Bone marrow lesions are associated with altered trabecular morphometry

Driban

Tassinari

et al. 2012

Osteoarthritis and Cartilage

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Objective Bone marrow lesions (BMLs) are a common magnetic resonance (MR) feature in patients with osteoarthritis, however their pathological basis remains poorly understood and has not been evaluated in vivo. Our aim was to evaluate the trabecular structure associated with the presence and size of BMLs present in the same regions of interest (ROI) using quantitative MR-based trabecular morphometry. Design 158 participants in the Osteoarthritis Initiative (OAI) were imaged with a coronal 3D FISP sequence for trabecular morphometry in the same session as the OAI 3T MR knee evaluation. The proximal medial tibial subchondral bone in the central weight-bearing ROI on these knee 3D FISP images were quantitatively evaluated for apparent bone volume fraction, trabecular number, spacing, and thickness. BMLs were also evaluated in the subchondral bone immediately adjacent to the articular cartilage. BML volume was also evaluated within the same trabecular morphometry ROI and semi-quantitatively classified as none, small, or large. Kruskal-Wallis test was used to determine if mean apparent bone volume fraction, trabecular number, spacing, or thickness differed by BML score. Results Compared to knees with ROIs containing no BMLs, knees with small or large BMLs had statistically higher apparent bone volume fraction (p<0.01), trabecular number (p<0.01), and thickness (p=0.02), and lower trabecular spacing (p<0.01). Conclusions Compared to knees with ROIs containing no BMLs, knees with ROIs containing small or large BMLs had higher apparent bone volume fraction, trabecular number and thickness, but lower trabecular spacing. These findings may represent areas of locally increased bone remodeling or compression.

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“…A micromechanical finite element model was constructed by converting bone voxels from the VOI into 8-node brick elements [20]. Compression testing was simulated on the proximal tibia metaphyseal region and the vertebral body…”

Section: Methodsmentioning

confidence: 99%

Ovariectomy and genes encoding core circadian regulatory proteins in murine bone

Smith¹,

Sutton²,

Wu³

et al. 2010

Osteoporos Int

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Summary This study investigated the influence of ovarian hormone deficiency on core circadian regulatory protein (CCRP) in the context of bone loss. Our data suggest that ovarian hormone deficiency disrupts diurnal rhythmicity and CCRP expression in bone. Further studies should determine if chronobiology provides a novel therapeutic target for osteoporosis intervention. Introduction CCRP synchronize metabolic activities and display an oscillatory expression profile in murine bone. In vitro studies using bone marrow mesenchymal stromal/stem cells have demonstrated that the CCRP is present and can be regulated within osteoblast progenitors. In vivo studies have shown that the CCRP regulates bone mass via leptin/neuroendocrine pathways. The current study used an ovariectomized murine model to test the hypothesis that ovarian hormone deficiency is associated with either an attenuation and/or temporal phase shift of the CCRP oscillatory expression in bone and that these changes are correlated with the onset of osteoporosis. Methods Sham-operated controls and ovariectomized female C57BL/6 mice were euthanized at 4-h intervals 2 weeks post-operatively. Results Ovariectomy attenuated the oscillatory expression of CCRP mRNAs in the femur and vertebra relative to the controls and reduced the wheel-running activity profile. Conclusion Ovarian hormone deficiency modulates the expression profile of the CCRP with potential impact on bone marrow mesenchymal stem cell lineage commitment.

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In Vivo Assessment of Architecture and Micro-Finite Element Analysis Derived Indices of Mechanical Properties of Trabecular Bone in the Radius

Cited by 83 publications

References 20 publications

Microarchitecture and bone quality in the human calcaneus: Local variations of fabric anisotropy

Microarchitecture and bone quality in the human calcaneus: Local variations of fabric anisotropy

Bone marrow lesions are associated with altered trabecular morphometry

Ovariectomy and genes encoding core circadian regulatory proteins in murine bone

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