In-vivo assessment of the osteo-protective effects of eugenol in alveolar bone tissues

Abuohashish, Hatem M.; Khairy, Dina A.; Abdel‐Salam, M.; Alsayyah, Ahmed; Ahmed, Mohammed M.; Al-Rejaie, Salim S.

doi:10.1016/j.biopha.2017.11.068

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…Moreover, eugenol supplementation to DENA/AAF-administered rats exhibited a significant reduction in TNF-α and IL-1β levels. These results are corroborated by those of Abuohashish et al [ 52 ], who observed that the anti-inflammatory activity of eugenol was crucial, as it was followed by a decrease in levels of IL-1β and TNF-α. Eugenol is involved in the transcription of various factors that influence the inflammatory process, including NF-κB, and several cytokines, such as TNF-α and IL-1β [ 53 ].…”

Section: Discussionsupporting

confidence: 86%

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

et al. 2023

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This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer. Graphical abstract

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Section: Discussionsupporting

confidence: 86%

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

et al. 2023

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“…A recent study demonstrated that eugenol administration for twelve weeks attenuated the alveolar bone loss and remodeling associated with estrogen insufficiency using an ovariectomized (OVX) rat model, which is similar to what occurs after menopause in humans. The authors suggested that anti-inflammatory effect of eugenol had primary importance, since it was accompanied by the reduction of IL-1 β , IL-6, and TNF- α levels resulting in the reduction of inflammatory cell [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

An Overview on the Anti‐inflammatory Potential and Antioxidant Profile of Eugenol

Barboza

Filho

Silva

et al. 2018

Oxidative Medicine and Cellular Longevity

235

155

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The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against several diseases, such as those associated with inflammatory processes, which are commonly related to oxidative stress. Many of these compounds have an appreciable inhibitory effect on oxidative stress and inflammatory response, and may contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, action on the redox status, and applications in the food and pharmaceutical industry. Considering the importance of this compound, the present review discusses its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases.

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“…Recent animal studies confirmed that various phenolic compounds in different vegetable species (e.g., eugenol or salicylic acid) exert beneficial effects on bone [55,56]. Further, in vivo studies are required to verify our in vitro findings on the effects on bone metabolism of the phenolic compounds in EVOO.…”

Section: Discussionmentioning

confidence: 92%

Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression

et al. 2019

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The phenolic compounds of extra-virgin olive oil can act at various levels to protect individuals against cardiovascular and neurodegenerative diseases, cancer, and osteoporosis, among others. Polyphenols in extra-virgin olive oil can stimulate the proliferation of osteoblasts, modify their antigen profile, and promote alkaline phosphatase synthesis. The objective of this work was to determine the effect of different extra-virgin olive oil phenolic compounds on the gene expression of osteoblast-related markers. The cells of the MG63 osteoblast line were cultured for 24 h with 10-6 M of the phenolic compounds ferulic acid, caffeic acid, coumaric acid, apigenin, or luteolin. The expression of studied markers was quantified using quantitative real-time polymerase chain reaction (q-RT-PCR). The expression by MG63 osteoblasts of growth and differentiation/maturation markers was modified after 24 h of treatment with 10-6 M of the phenolic compounds under study, most of which increased the gene expression of the transforming growth factor β1 (TGF-β1), TGF-β receptor 1,2 and 3 (TGF-βR1, TGF-βR2, TGF-βR3), bone morphogenetic protein 2 and 7 (BMP2, BMP7), run-related transcription factor 2 (RUNX-2), Alkaline phosphatase (ALP), Osteocalcin (OSC), Osterix (OSX), Collagen type I (Col-I) and osteoprotegerin (OPN). The extra-virgin olive oil phenolic compounds may have a beneficial effect on bone by modulating osteoblast physiology, which would support their protective effect against bone pathologies.

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In-vivo assessment of the osteo-protective effects of eugenol in alveolar bone tissues

Cited by 15 publications

References 28 publications

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

An Overview on the Anti‐inflammatory Potential and Antioxidant Profile of Eugenol

Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression

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