In vivo assessment of white matter damage in neuromyelitis optica: A diffusion tensor and diffusion kurtosis MR imaging study

Kimura, Margareth; Doring, Thomas M.; Rueda, Fernanda; Tukamoto, Gustavo; Gasparetto, Emerson L.

doi:10.1016/j.jns.2014.07.035

Cited by 23 publications

(20 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, studies using volumetrics [23], spectroscopy [22], and diffusion tensor imaging (DTI) [24] have shown that diffuse brain atrophy in NMOSD is less pronounced than in MS, or even similar to healthy control subjects. Other studies identified widespread brain alterations in NMOSD [21,26]. These changes were, however, less severe than in MS, which is in line with our results showing a weak trend of smaller PVA values in NMOSD versus healthy volunteers.…”

Section: Discussionsupporting

confidence: 92%

“…Whether, and to what extent diffuse brain damage occurs in NMOSD is a matter of controversy [21][22][23][24][25]. On the one hand, studies using volumetrics [23], spectroscopy [22], and diffusion tensor imaging (DTI) [24] have shown that diffuse brain atrophy in NMOSD is less pronounced than in MS, or even similar to healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Schumacher

Pache

Bellmann‐Strobl

et al. 2016

Magn Reson Mater Phy

View full text Add to dashboard Cite

Object:To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to multiple sclerosis (MS) and healthy control subjects. Materials and Methods:Sixteen NMOSD, sixteen MS and sixteen healthy control subjects (HC) underwent 7.0 Tesla (7T) MRI. The imaging protocol included T 2 * weighted (T2*w) fast low angle shot (FLASH) and fluid attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region-of-interest based approach. Results:No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p=0.226). In contrast, PVA was significantly reduced in MS patients compared to HC (p=0.013). Conclusion:Unlike in MS, patients suffering from NMOSD did not show a reduced venous visibility.This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system. 5

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Schumacher

Pache

Bellmann‐Strobl

et al. 2016

Magn Reson Mater Phy

View full text Add to dashboard Cite

show abstract

“…Previous neuroimaging studies focusing on NMOSD showed that there were FA reductions in the corpus callosum (Kimura et al, 2014), optic radiation (Kimura et al, 2014;Pichiecchio et al, 2012), and cortico-spinal tract (Yu et al, 2008). A recent TBSS analysis of NMOSD patients revealed reduced FA involving diffuse subcortical white matter of the frontal, parietal, temporal, occipital, and limbic lobes, brainstem and cerebellum (von Glehn et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis optica spectrum disorder and multiple sclerosis: Differentiation by a multimodal approach

Ota

Sato

Okamoto

et al. 2015

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

“…In MS, lesions are small, non-edematous, and the intensity is homogenous in the acute phase and they are more commonly located at lower margin of CC. [56][57][58][59] As Chen et al [6] showed in their study, subcallosal dash dot sign was helpful as it was more common in patient with MS than in the NMO. In another study by Makino et al, [36] it was showed that involvement of splenium of CC in NMO patients was more common than the involvement of the same area in patients with MS (57% vs. 27%).…”

Section: In Devic's Neuromyelitis Optica Mrimentioning

confidence: 82%

“…According to the study by Kimura et al [58] in patients with NMO, damage to extensive regions of NAWM has been observed. To investigate this possibility that microstructural alterations are present in these WM tracts, DTI should be applied.…”

Section: Functional Mrimentioning

confidence: 98%

Neuroimaging of corpus callosum in central nervous system demyelinating disorders

Etemadifar¹,

Neshatfar²,

Zamani³

et al. 2017

View full text Add to dashboard Cite

Corpus callosum (CC) is the largest white matter structure in the brain, consisting of 200-250 million contralateral axonal projections. It is the major commissural pathway connecting the hemispheres of human brain. The pathology of CC includes wide variety of entities that arise from different causes such as congenital, inflammatory, tumoral, degenerative, infectious, etc. This study reviews the most reliable neuroimaging data of human CC in central nervous system (CNS) demyelinating diseases to facilitate the understanding of different pathological entities of the CC and their role in anticipation of probable prognostic findings. After a brief description of normal anatomy and functions of CC, this review examines the most valuable findings obtained using conventional and functional magnetic resonance imaging. It also demonstrates the most well organized findings of how CC features influence prognostic factors of demyelinating disorders, which could have a great value for choosing proper therapy methods. The authors also provided a brief review of other demyelinating disorders which are primarily caused by other pathological factors other than autoimmunity. As a conclusion, the authors showed the importance of CC as an critical part of the brain, which should be explored by different methods of imaging, correspondent to clinical evaluation of CNS demyelinating disorder to widen our knowledge on pathology and clinical patterns of such disorders. Key words:Corpus callosum, central nervous system, demyelinating diseases, neuroimaging, review ABSTRACTArticle history:

show abstract

In vivo assessment of white matter damage in neuromyelitis optica: A diffusion tensor and diffusion kurtosis MR imaging study

Cited by 23 publications

References 31 publications

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Neuromyelitis optica spectrum disorder and multiple sclerosis: Differentiation by a multimodal approach

Neuroimaging of corpus callosum in central nervous system demyelinating disorders

Contact Info

Product

Resources

About