In vivo behavior of three different injectable hydraulic calcium phosphate cements

Apelt, Detlef; Theiss, Felix; El-Warrak, A. O.; Zlinszky, K.; Bettschart‐Wolfensberger, Regula; Bohner, Marc; Matter, S.; Auer, Jörg A; Rechenberg, Brigitte von

doi:10.1016/j.biomaterials.2003.08.073

Cited by 339 publications

(317 citation statements)

References 47 publications

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“…Standard pre-surgery procedures and anesthesia were used. 15 We made a lateral curved incision centered anterior to the greater trochanter with the sheep in lateral recumbency. The lateral femur was exposed by partially releasing the attachments of the vastus lateralis and intermedius muscles.…”

Section: Study Protocolmentioning

confidence: 99%

Experimentally induced cam impingement in the sheep hip

Siebenrock

Fiechter

Tannast

et al. 2012

Journal Orthopaedic Research

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Sheep hips have a natural non-spherical femoral head similar to a cam-type deformity in human beings. By performing an intertrochanteric varus osteotomy, cam-type femoro-acetabular impingement (FAI) during flexion can be created. We tested the hypotheses that macroscopic lesions of the articular cartilage and an increased Mankin score (MS) can be reproduced by an experimentally induced cam-type FAI in this ovine in vivo model. Furthermore, we hypothesized that the MS increases with longer ambulatory periods. Sixteen sheep underwent unilateral intertrochanteric varus osteotomy of the hip with the non-operated hip as a control. Four sheep were sacrificed after 14, 22, 30, and 38-weeks postoperatively. We evaluated macroscopic chondrolabral alterations, and recorded the MS, based on histochemical staining, for each ambulatory period. A significantly higher prevalence of macroscopic chondrolabral lesions was found in the impingement zone of the operated hips. The MS was significantly higher in the acetabular/femoral cartilage of the operated hips. Furthermore, these scores increased as the length of the ambulatory period increased. Pathologic abutment between the proximal femur and the acetabular rim, termed ''femoro-acetabular impingement'' (FAI), has recently been proposed as a pathomechanism for development of early osteoarthritis of the hip.1,2 This impingement represents a dynamic overload of the affected areas of the acetabulum. ''Cam-type'' impingement is caused by an aberrant non-spherical femoral head. In theory, abnormal shear forces are transmitted to the antero-superior portion of the acetabulum during the end range of flexion and internal rotation.2,3 These abnormal shear forces result in a cascade of chondrolabral degeneration in the acetabulum, as well as degeneration of cartilage on the aspherical portion of the femoral head.

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Section: Study Protocolmentioning

confidence: 99%

Experimentally induced cam impingement in the sheep hip

Siebenrock

Fiechter

Tannast

et al. 2012

Journal Orthopaedic Research

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“…Even though the CPC shows almost equivalent CT density to bone, biopsy of the reconstructed site is required to assure bone ingrowth into cement restoration. Although no biopsy study is carried out during our follow-up period, numbers of orthopedic studies on long bones encourage the results with brushite cements 1,10) . From a practical view point, because the craniofacial skeleton is a non stress-bearing site, the fact that the CPC does not totally convert to bone is not vital.…”

Section: Discussionmentioning

confidence: 99%

Clinical Experience of the Brushite Calcium Phosphate Cement for the Repair and Augmentation of Surgically Induced Cranial Defects Following the Pterional Craniotomy

Ahn

2010

J Korean Neurosurg Soc

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Objective : To prevent temporal depression after the pterional craniotomy, this study was designed to examine the safety and aesthetic efficacy of the brushite calcium phosphate cement (CPC) in the repair and augmentation of bone defects following the pterional craniotomy. Methods : The brushite CPC was used for the repair of surgically induced cranial defects, with or without augmentation, in 17 cases of pterional approach between March, 2005 and December, 2006. The average follow-up month was 20 with range of 12-36 months. In the first 5 cases, bone defects were repaired with only brushite CPC following the contour of the original bone. In the next 12 cases, bone defects were augmented with the brushite CPC rather than original bone contour. For a stability monitoring of the implanted brushite CPC, post-implantation evaluations including serial X-ray, repeated physical examination for aesthetic efficacy, and three-dimensional computed tomography (3D-CT) were taken 1 year after the implantation. Results : The brushite CPC paste provided precise and easy contouring in restoration of the bony defect site. No adverse effects such as infection or inflammation were noticed during the follow-up periods from all patients. 3D-CT was taken 1 year subsequent to implantation showed good preservation of the brushite CPC restoration material. In the cases of the augmentation group, aesthetic outcomes were superior compared to the simple repair group. Conclusion : The results of this clinical study indicate that the brushite CPC is a biocompatible alloplastic material, which is useful for prevention of temporal depression after pterional craniotomy. Additional study is required to determine the long-term stability and effectiveness of the brushite calcium phosphate cement for the replacement of bone.

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“…The ovine model is well established in orthopaedic and biomedical research [1][2][3][4][5]10]. The similarity in lamellar bone structure to humans has made this model common in research involving fracture healing, osteosynthesis techniques and implant osseointegration [3,21,22]. There is a close resemblance between bone from the sheep pelvic region and the human mandible.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Various Positions on the Ovine Pelvis for Dental Implant Research

Kloppers¹

2016

IJDOS

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Aims: An ex vivo and in vivo study to determine various positions in the ovine pelvis to evaluate dental implant placement. Settings and Design:• A novel, unique surgical dissection was described as the caudal roll-up technique and was utilized to obtain maximal exposure to the Linea Glutea, with the least morbidity.• Insertion torque (IT) of osseo-integrated dental implants was measured at predetermined positions described as A-F along the ovine linea glutea.• The amount of outer cortical bone was measured at predetermined sections A-F on harvested ovine pelvi, to coincide with the implant positions as placed. Statistical analysis used: Descriptive Study.Intraoral dental implant research in animals is challenging, owing in particular to different tooth morphology. One of the most challenging problems with intraoral implant research in animals is an infection form contaminated oral cavity, which is evident in intraoral research related to pigs and dogs [8]. Intraoral dental implant studies by Vlaminck confirmed that the specific oral biomechanics inherent to a sheep's constant ruminant activity accounted for high degrees of implant failures [13,25]. A novel, unique surgical dissection was described as the caudal roll-up technique and was utilized to obtain maximal exposure to the Linea Glutea, with the least morbidity. Data collected concerning the insertion torque of implants placed and the cortical thickness measurements of the sheep's ilia was discussed.

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In vivo behavior of three different injectable hydraulic calcium phosphate cements

Cited by 339 publications

References 47 publications

Experimentally induced cam impingement in the sheep hip

Experimentally induced cam impingement in the sheep hip

Clinical Experience of the Brushite Calcium Phosphate Cement for the Repair and Augmentation of Surgically Induced Cranial Defects Following the Pterional Craniotomy

Evaluation of Various Positions on the Ovine Pelvis for Dental Implant Research

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