In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant

Mi, Fwu Long; Tan, Yu Chiun; Liang, Hsiang Fa; Sung, Hsing‐Wen

doi:10.1016/s0142-9612(01)00094-1

Cited by 510 publications

(333 citation statements)

References 37 publications

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“…Crosslinking the chitosan film might aid in extending release of the incorporated antibiotic. Studies have been performed using different crosslinking agents in combination with chitosan [17,24,36]. Genipin is a naturally occurring crosslinking agent that is several thousand times less cytotoxic than glutaraldehyde [36].…”

Section: Discussionmentioning

confidence: 99%

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Noel

Courtney

Bumgardner

et al. 2008

Clinical Orthopaedics &Amp; Related Research

105

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Local antibiotic delivery is an emerging area of study designed to provide alternative methods of treatment to clinicians for compromised wound sites where avascular zones can prevent the delivery of antibiotics to the infected tissue. Antibiotic-loaded bone cement is the gold standard for drug-eluting local delivery devices but is not ideal because it requires a removal surgery. Chitosan is a biocompatible, biodegradable polymer that has been used in several different drug delivery applications. We evaluated chitosan as a potential localized drug delivery device. We specifically determined if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting S. aureus growth. Elution of amikacin was 24.67 ± 2.35 lg/mL (85.68%) after 1 hour with a final cumulative release of 27.31 ± 2.86 lg/mL (96.23%) after 72 hours. Elution of daptomycin was 10.17 ± 3.83 lg/mL after 1 hour (31.61% release) and 28.72 ± 6.80 lg/mL after 72 hours (88.55%). The data from the elution study suggested effective release of amikacin and daptomycin. The activity studies indicated the eluants inhibited the growth of S. aureus. Incorporating antibiotics in chitosan could provide alternative methods of treating musculoskeletal infections.

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Section: Discussionmentioning

confidence: 99%

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Noel

Courtney

Bumgardner

et al. 2008

Clinical Orthopaedics &Amp; Related Research

105

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“…The cross-linking mechanism involves a nucleophilic attack by the amino group of chitosan on to the olefinic carbon atom at C-3 of genipin, followed by the opening of the dihydropyran ring. The formation of a secondary amide and a heterocyclic amino linkage leads to the cross-linking of chitosan [62].…”

Section: Genipinmentioning

confidence: 99%

“…For example, genipin was used for cross-linking chitosan and chitosan-poly(ethylene oxide) by mixing the corresponding polymer solutions with genipin [62]. Genipin cross-linked chitosan microspheres were also prepared by other techniques like spray drying [63] or water-in-oil emulsion [64,65].…”

Section: Genipinmentioning

confidence: 99%

Approaches for Functional Modification or Cross‐Linking of Chitosan

Anitha

Rejinold

Bumgardner

et al. 2012

Chitosan‐Based Systems for Biopharmaceuticals

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“…Electrospinning technique is a simple method and effective to fabricate nanometer-sized fibers [5,6]. To obtain the nanofiber PVA/CS, which has a hydrogel structure and increased the value of stability in water, fiber PVA/Chitosan need the stabilization process that could be obtained by crosslinking using chemicals by using Glutaraldehyde (GA) or by increasing the crystallinity of membrane using with heat treatment [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan concentration and heat treatment on electrospun PVA/Chitosan nanofibers

Riwu¹,

Loi²,

Kusumaatmaja³

et al. 2016

AIP Conference Proceedings

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Abstract. Electrospun nanofibers membrane were fabricated from poly(vinyl alcohol)/chitosan (PVA/CS) with a mass ratio of 70/30 and 50/50 in 2% acetic acid solvent by electrospinning method. The morphology of nanofibers membrane of PVA/CS before-after heat treatment and effect after immersion in Glutaraldehyde was investigated by the field emission scanning electron microscopy (SEM). The diameter of PVA/CS 50/50 and 70/30 nanofibers was approximately 190 nm and 580 nm. Fourier Transform Infrared analysis demonstrated the existence of relevant functional groups of both PVA/CS 50/50 and 70/30 nanofibers. It is also shown that heat treatment increases the water resistance of PVA/CS membrane.

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In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant

Cited by 510 publications

References 37 publications

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Approaches for Functional Modification or Cross‐Linking of Chitosan

Effect of Chitosan concentration and heat treatment on electrospun PVA/Chitosan nanofibers

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