In vivo biocompatibility evaluation of Zn-0.05Mg-(0, 0.5, 1wt%)Ag implants in New Zealand rabbits

Xiao, Chi; Shi, Xin; Yu, Wei; Xiao, Wenbin; Cheng, Liang; Qiu, Xing; Li, Bo Rui; Fan, De Chao; Li, Jun Lei; Zhang, Xiu Zhi; Zhao, Dewei

doi:10.1016/j.msec.2020.111435

Cited by 19 publications

(12 citation statements)

References 43 publications

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“…The indirect evidence for twinning activation during HE sample deformation is a peak in misorientation angle distribution related to

twin boundary at ~86° observed in CR samples. Typically, when the contribution of twinning in the total deformation of Zn-based alloys increases, a higher strengthening effect, and lower plasticity is observed [ 6 , 9 , 17 ]. Therefore, despite the excellent tensile strength of the Zn–3Ag-0.5Mg alloy, inadequate ductility in the HE state was still an issue to address in further processing steps.…”

Section: Discussionmentioning

confidence: 99%

“…The cytotoxic effect is rarely directly triggered by the alloying element, especially at their low concentrations, but is rather caused by Zn alloys' degradation behavior in used culture media and the amount of released Zn 2+ ions that affect the cell viability [ 2 , 3 ]. As a result, despite the in vitro experimental results indicating a cytotoxic effect of Zn alloys, there are studies confirming their excellent in vivo biocompatibility, no harmful effects on the animal organs, good hemocompatibility, proper vascular healing, or new bones formation [ [4] , [5] , [6] , [7] ].…”

Section: Introductionmentioning

confidence: 99%

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Fine-tuning of mechanical properties in a Zn–Ag–Mg alloy via cold plastic deformation process and post-deformation annealing

Wątroba

Bednarczyk

Kawałko

et al. 2021

Bioactive Materials

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In recent years, Zn-based materials have been extensively investigated as potential candidates for biodegradable implant applications. The introduction of alloying elements providing solid-solution strengthening and second phase strengthening seems crucial to provide a suitable platform for the thermo-mechanical strengthening of Zn alloys. In this study, a systematic investigation of the microstructure, crystallographic texture, phase composition, and mechanical properties of a Zn–3Ag-0.5Mg (wt%) alloy processed through combined hot extrusion (HE) and cold rolling (CR), followed by short-time heat treatment (CR + HT) at 200 °C was conducted. Besides, the influence of different annealing temperatures on the microstructure and mechanical properties was studied. An adequate combination of processing conditions during CR and HT successfully addressed brittleness obtained in the high-strength HE Zn–3Ag-0.5Mg alloy. By controlling the microstructure, the most promising results were obtained in the sample subjected to 50% CR reduction and 5-min annealing, which were: ultimate tensile strength of 432 MPa, yield strength of 385 MPa, total elongation to failure of 34%, and Vickers microhardness of 125 HV0.3. The obtained properties clearly exceed the mechanical benchmarks for biodegradable implant materials. Based on the conducted investigation, brittle multi-phase Zn alloys' mechanical performance can be substantially enhanced to provide sufficient plasticity by grain refinement through cold deformation process, followed by short-time annealing to restore proper strength.

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“…The indirect evidence for twinning activation during HE sample deformation is a peak in misorientation angle distribution related to

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine-tuning of mechanical properties in a Zn–Ag–Mg alloy via cold plastic deformation process and post-deformation annealing

Wątroba

Bednarczyk

Kawałko

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

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“…Although Mg is a physiologically essential element with good toleration; Mg alone cannot provide the implant with the desired mechanical strengths and degradation rate. Hence, these implants are mostly supplemented with other elements such as Gadolinium (Gd) [ [149] , [150] , [151] ] and Silver (Ag) [ [152] , [153] , [154] ], which can modulate immune cell function [ 57 ].…”

Section: Immune Response Differences Between Degradable and Non-degra...mentioning

confidence: 99%

Immune response differences in degradable and non-degradable alloy implants

Khodaei

Schmitzer

Suresh

et al. 2023

Bioactive Materials

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“…Currently, there is not much in vivo research on the biosafety of antimicrobial Zn alloys, most of which are focused on Zn-Mg alloys ( Xiao et al, 2018 ; Wang et al, 2019 ; Xiao et al, 2021b ). Nonetheless, due to the differences in the degradable environment and sensitivity ( Xiao et al, 2018 ), there is an apparent discrepancy between in vivo and in vitro results on the biocompatibility of alloys ( Čapek et al, 2021 ).…”

Section: Research Progress Of Mg- Zn- and Fe-based Alloy Orthopedic I...mentioning

confidence: 99%

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Wang

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Implant-associated infection (IAI) is one of the major challenges in orthopedic surgery. The development of implants with inherent antibacterial properties is an effective strategy to resolve this issue. In recent years, biodegradable alloy materials have received considerable attention because of their superior comprehensive performance in the field of orthopedic implants. Studies on biodegradable alloy orthopedic implants with antibacterial properties have gradually increased. This review summarizes the recent advances in biodegradable magnesium- (Mg-), iron- (Fe-), and zinc- (Zn-) based alloys with antibacterial properties as orthopedic implant materials. The antibacterial mechanisms of these alloy materials are also outlined, thus providing more basis and insights on the design and application of biodegradable alloys with antibacterial properties as orthopedic implants.

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In vivo biocompatibility evaluation of Zn-0.05Mg-(0, 0.5, 1wt%)Ag implants in New Zealand rabbits

Cited by 19 publications

References 43 publications

Fine-tuning of mechanical properties in a Zn–Ag–Mg alloy via cold plastic deformation process and post-deformation annealing

Fine-tuning of mechanical properties in a Zn–Ag–Mg alloy via cold plastic deformation process and post-deformation annealing

Immune response differences in degradable and non-degradable alloy implants

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

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