In-vivo biocompatibility evaluation of stents coated with a new biodegradable elastomeric and functional polymer

Lee, Seung H.; Szinai, I.; Carpenter, Kenneth G.; Katsarava, Ramaz; Jokhadze, Giuli; Chu, Chih‐Chang; Huang, Yanming; Verbeken, Eric; Bramwell, Orville; Scheerder, Ivan De; Hong, Mun K.

doi:10.1097/00019501-200206000-00006

Cited by 65 publications

(61 citation statements)

References 20 publications

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“…In particular, copoly(ester amide)s based on -amino acids (e.g., L-leucine and L-lysine), diols and dicarboxylic acids were demonstrated to be biocompatible with the arterial walls [90,91]. Furthermore, PEAs coatings loaded with a 50% of tempamine had a tendency to decrease arterial injury as demonstrated by in vivo studies, in contrast with the severe inflammation observed when stents were directly loaded with the drug (i.e., without using the polymer coating) [92].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Degradable Poly(ester amide)s for Biomedical Applications

2010

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Poly(ester amide)s are an emerging group of biodegradable polymers that may cover both commodity and speciality applications. These polymers have ester and amide groups on their chemical structure which are of a degradable character and provide good thermal and mechanical properties. In this sense, the strong hydrogen-bonding interactions between amide groups may counter some typical weaknesses of aliphatic polyesters like for example poly(-caprolactone). Poly(ester amide)s can be prepared from different monomers and following different synthetic methodologies which lead to polymers with random, blocky and ordered microstructures. Properties like hydrophilic/hydrophobic ratio and biodegradability can easily be tuned. During the last decade a great effort has been made to get functionalized poly(ester amide)s by incorporation of -amino acids with hydroxyl, carboxyl and amine pendant groups and also by incorporation of carbon-carbon double bonds in both the polymer main chain and the side groups. Specific applications of these materials in the biomedical field are just being developed and are reviewed in this work (e.g., controlled drug delivery systems, hydrogels, tissue engineering and other uses like adhesives and smart materials) together with the main families of functionalized poly(ester amide)s that have been developed to date.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Degradable Poly(ester amide)s for Biomedical Applications

2010

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“…To allow a controlled drug release, a variety of biomaterials/polymers such as copoly(ester-amide)elastomers [77] and phosphorylcholine have been tested especially with view to drug release fromulas, a reduction in platelet and protein adhesion, and the capability of an endothelialization of the stent [78 -81]. Progress with such polymers has founded the era of drug-coated stents.…”

Section: Drug-dose Response and Latencies In Vivomentioning

confidence: 99%

Biological aspects of radiation and drug-eluting stents for the prevention of restenosis

Sindermann

Verin

Hopewell

et al. 2004

Cardiovascular Research

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Based on recent advances, this article aims to review the biological basis for the use of either radiation or drug-eluting stents for the prevention of restenosis, and to elucidate the complementary role that they may play in the future. Vascular restenosis is a multifactorial process primarily driven by the remodeling of the arterial wall, as well as by the hyperproliferation of smooth muscle cells (SMC). These pathophysiological features are the target of therapeutic strategies aimed at inhibiting constrictive remodeling as well as inhibiting SMC proliferation. The success of radiation as well as anti-proliferative drugs such as paclitaxel and sirolimus lies in the primary and/or multifactorial inhibition of cell proliferation. Radiation has the additional feature of preventing constrictive remodeling while sirolimus has the potential property of being anti-inflammatory, which may be a desirable feature. The effects of radiation are not reliant on any uptake and ''metabolism'' by the target cells, as in the case with drugs, and thus radiation potentially may be more effective as a result of its more-direct action. However, radiation does have some significant drawbacks compared to drug-eluting stents, including a much delayed re-endothelialization resulting in the need for prolonged anti-platelet therapy. Based on recent clinical data, drug-eluting stents have been shown to markedly reduce the likelihood of restenosis, which actually favors this approach for the prevention of restenosis. From a biological perspective, drug-eluting stents and radiation have certain differences, which are reviewed in this article.

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“…For example, biodegradable elastomeric scaffolds enable the construction or modelling of several soft tissues that include blood vessels, cartilage, smooth muscle cells and cardiovascular tissue [13,14]. Besides that, different implantable devices such as stents, sutures and biosensors can contain biodegradable elastomer parts integrated within their design [15][16][17]. Actifit™ is a segmented aliphatic PU based on poly(ε-caprolactone) (PCL), and 1,4-butane diisocyanate (BDI), which has recently arrived on the market.…”

Section: Introductionmentioning

confidence: 99%