In Vivo Biocompatibility of a Novel Ceramic-Metal Biocomposite

Abstract

An in vivo biocompatibility test of a novel biocomposite, with major phases of CaTiO3 and Ti2O, and minor phases of AlTi3, TiO, CaO and Al2O3, was conducted on rats using subcutaneous implantation. The biocomposite and titanium alloy control specimens were removed at 6 and 14 weeks post-implantation. Histological examination revealed no significant adverse reaction of the surrounding tissue to the either the biocomposite or the control material. We conclude that the composite is well tolerated in a physiological environment.

Phenylalanine near Inorganic Surfaces: Conformational Statistics vs Specific Chemistry

“…[13][14][15][16] Of particular interest is the case of biomolecules; this is extremely important for several emerging fields of biophysics and biochemistry, such as the design of biomedical devices [17][18][19][20] and of biocompatible materials. 21,22 The above-mentioned interaction between biomolecules and inorganic surfaces is a rather complex problem. As the size of the molecule increases, the number of conformational states accessible becomes larger and the specific chemical structure becomes less relevant; thus statistical generic models are computationally convenient and theoretically well founded for describing the large scale conformational properties.…”

“…The behavior of large molecules near inorganic substrates is becoming a field of rapidly growing interest due to its relevance in many problems of condensed matter and chemistry, from catalysis, − through the understanding of chirality, − to the design of materials properties. − Of particular interest is the case of biomolecules; this is extremely important for several emerging fields of biophysics and biochemistry, such as the design of biomedical devices − and of biocompatible materials. , The above-mentioned interaction between biomolecules and inorganic surfaces is a rather complex problem. As the size of the molecule increases, the number of conformational states accessible becomes larger and the specific chemical structure becomes less relevant; thus statistical generic models are computationally convenient and theoretically well founded for describing the large scale conformational properties.…”

Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

“…This procedure and the results for the cp-Ti are adapted from the study by Al-Zain et al [31] In Vivo Implantation Tests and Histological Evaluation: Both the control material (cp-Ti) and the 2.5Mo alloy specimens were implanted subcutaneously in 30 adult BALB/c rats with an average mass of 181.4 AE 36.7 g. The anesthetic protocol for all rats included intraperitoneal ketamine injection by a standard dose of 50 mg kg À1 body mass as demonstrated by previous investigators. [14,35,36] Each rat received the 2.5Mo alloy and cp-Ti specimens under subcutaneous tissue located immediately posterior to the right and left shoulder blades after appropriate shaving of the fur and sterilizing the area with 10% povidone iodine solution. The pockets for inserting the test specimens were created using a clean sharp blade and the incision was then closed utilizing a 3-0 silk suture.…”