In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration

Yang, Kai; Gong, Hua; Shi, Xiaoze; Wan, Jian; Zhang, Youjiu; Liu, Zhuang

doi:10.1016/j.biomaterials.2013.01.001

Cited by 381 publications

(321 citation statements)

References 52 publications

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“…4,5 Biopolymer surface-functionalized GO nanosheets were reported to be biocompatible and non-toxic at low concentrations. 6,7 GO has recently been applied to prepare polymer nanocomposite hydrogels with improved mechanical performance compared to conventional hydrogels, 8,9 and various self-assembly approaches were used to prepare physically cross-linked GO-polymer nanocomposite hydrogels. 10,11 The driving forces to form these hydrogels were physical interactions including π-π interaction, hydrogen bonding, electrostatic interaction and coordination.…”

Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Piao

Chen

2016

Ind. Eng. Chem. Res.

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Graphene oxide (GO)-polyamidoamine (PAMAM) dendrimer nanocomposite hydrogels were prepared through one-step synthesis by mixing a GO suspension and a PAMAM solution at varying ratio of GO to PAMAM. The materials self-assembled into physically crosslinked networks, mainly driven by electrostatic interactions between the oppositely charged GO nanosheets and PAMAM dendrimer. The chemical structure of PAMAM dendrimer was studied by mass spectrometry, nuclear magnetic resonance spectroscopy and potentiometric titration.The structure and properties of GO-PAMAM nanocomposite hydrogels were investigated by Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction, scanning electron microscopy and rheometry. The nanocomposite hydrogels exhibited a relatively high mechanical performance with a storage modulus of up to 284 kPa, as well as self-healing property, owing to their reversible and multiple physical cross-links. These hydrogels may be further developed for biomedical applications.2

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Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Piao

Chen

2016

Ind. Eng. Chem. Res.

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“…Although both materials (ie, RGO-PEG, nRGO-PEG) accumulated in the liver, liver toxicology tests indicated normal ranges up to 90 days. 24 Oral administration of both RGO-PEG (65 nm) and nRGO-PEG (27 nm) recorded the highest accumulation in stomach, but cleared after a day. In contrast, intraperitoneal injection (in the abdominal cavity) sustained liver and spleen accumulation even after 7 days.…”

Section: Carbon Nanomaterials (Graphene Dot Nanotube)mentioning

confidence: 96%

Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency

Kim¹,

Khang²

2015

IJN

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Over the past 60 years, numerous medical strategies have been employed to overcome neoplasms. In fact, with the exception of lung, bronchial, and pancreatic cancers, the 5-year survival rate of most cancers currently exceeds 70%. However, the quality of life of patients during chemotherapy remains unsatisfactory despite the increase in survival rate. The side effects of current chemotherapies stem from poor target efficiency at tumor sites due to the uncontrolled biodistribution of anticancer agents (ie, conventional or current approved nanodrugs). This review discusses the effective physiochemical factors for determining biodistribution of nanocarriers and, ultimately, increasing tumor-targeting probability by avoiding the reticuloendothelial system. Second, stem cell-conjugated nanotherapeutics was addressed to maximize the tumor searching ability and to inhibit tumor growth. Lastly, physicochemical material properties of anticancer nanodrugs were discussed for targeting cellular organelles with modulation of drug-release time. A better understanding of suggested topics will increase the tumor-targeting ability of anticancer drugs and, ultimately, promote the quality of life of cancer patients during chemotherapy.

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“…Unlike for IV administration, where tens of studies investigated the biodistribution and ability of different nanomedicines to accumulate at tumor sites [58,59], only (very) limited data are available on the biodistribution of NPs following IP injection (table 1). The biodistribution of non-PEGylated (450 nm in size) and PEGylated (30-100 nm in size) graphene oxide NPs was assessed in healthy animals following IP administration [60]. Aggregated and immobile…”

Section: Biodistribution Of Nps Following Ip Injectionmentioning

confidence: 99%

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

Dakwar

Shariati

Willaert

et al. 2017

Advanced Drug Delivery Reviews

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Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal carcinomatosis (PC). Over the past decade, a lot of effort has been put both in the academia and clinic in developing IP therapeutic approaches that maximize local efficacy while limiting systemic side effects. Also nanomedicines are under investigation for the treatment of tumors confined to the peritoneal cavity, due to their potential to increase the peritoneal retention and to target drugs to the tumor sites as compared to free drugs. Despite the progress reported by multiple clinical studies, there are no FDA approved drugs or formulations for specific use in the IP cavity yet. This review discusses the current clinical management of PC, as well as recent advances in nanomedicines-based IP delivery.We address important challenges to be overcome towards designing optimal nanocarriers for IP therapy in vivo.

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In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration

Cited by 381 publications

References 52 publications

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

One-Step Synthesis of Graphene Oxide–Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly

Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

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