2011
DOI: 10.1117/12.876414
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In vivo biodistribution of iron oxide nanoparticles: an overview

Abstract: Iron oxide nanoparticles present a promising alternative to conventional energy deposition-based tissue therapies. The success of such nanoparticles as a therapeutic for diseases like cancer, however, depends heavily on the particles’ ability to localize to tumor tissue as well as provide minimal toxicity to surrounding tissues and key organs such as those involved in the reticuloendothelial system (RES). We present here the results of a long term clearance study where mice injected intravenously with 2 mg Fe … Show more

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Cited by 35 publications
(35 citation statements)
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“…124 However, it is important to test the co-localization of the iron and fluorescent signals to make sure that the fluorescent signal is not just from the detached coating or fluorescent molecules due to their faster degradation and clearance rates. In a separate study, Tate et al 313 determined the amount of the IONPs in mice organs, 14 and 580 days after injection, and showed the complete clearance of the IONPs after 580 days. Note that this report only showed the results 14 and 580 days after injection without any intermediate time points and therefore the exact clearance time cannot be exactly established.…”
Section: Biodegradation and The Fate Of The Ionps In The Bodymentioning
confidence: 99%
“…124 However, it is important to test the co-localization of the iron and fluorescent signals to make sure that the fluorescent signal is not just from the detached coating or fluorescent molecules due to their faster degradation and clearance rates. In a separate study, Tate et al 313 determined the amount of the IONPs in mice organs, 14 and 580 days after injection, and showed the complete clearance of the IONPs after 580 days. Note that this report only showed the results 14 and 580 days after injection without any intermediate time points and therefore the exact clearance time cannot be exactly established.…”
Section: Biodegradation and The Fate Of The Ionps In The Bodymentioning
confidence: 99%
“…BMPs are 30-50 nm in diameter and have a zeta potential of −24.4± 4.0 mV (Sun et al 2009), which should theoretically facilitate uptake by liver (Xu et al 2009). However, as BMPs tend to agglomerate via magnetic polarity, the size of clumps might be >50 nm, resulting in uptake by other organs (Raynal et al 2004;Tate et al 2011). Such organspecific distribution could be advantageous for use of BMPs as drug carriers in targeted therapy for diseases of the lungs or liver, but disadvantageous for diseases of other organs.…”
Section: Discussionmentioning
confidence: 97%
“…Even with this, a pre-injection image is useful to determine background concentrations, especially in the abdominal region where even specially-formulated rodent chow for fluorescent imaging provides some background signal. Accurate quantification of fIONP in abdominally-located organs such as the liver and spleen is crucial to assessing fIONP biodistribution, as IONP have been shown to accumulate largely in the reticuloendothelial system ( 5, 6 ). The overall background will necessarily change over time with tissue scattering and as nanoparticle and fluorophore degrade.…”
Section: Discussionmentioning
confidence: 99%