2013
DOI: 10.1021/bm301694t
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In Vivo Biodistribution of Mixed Shell Micelles with Tunable Hydrophilic/Hydrophobic Surface

Abstract: The miserable targeting performance of nanocarriers for cancer therapy arises largely from the rapid clearance from blood circulation and the major accumulation in the organs of the reticuloendothelial system (RES), leading to inefficient enhanced permeability and retention (EPR) effect after intravenous injection (i.v.). Herein, we reported an efficient method to prolong the blood circulation of nanoparticles and decrease their deposition in liver and spleen. In this work, we fabricated a series of mixed shel… Show more

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Cited by 76 publications
(59 citation statements)
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“…Later, Gao et al [42] reported the synthesis of a series of mixed shell micelles (MSMs) with approximately the same size, charge and core composition. The micelles were formed by the spontaneous self-assembly of various amphiphilic block copolymers.…”
Section: Multi-responsive Micellesmentioning
confidence: 99%
See 1 more Smart Citation
“…Later, Gao et al [42] reported the synthesis of a series of mixed shell micelles (MSMs) with approximately the same size, charge and core composition. The micelles were formed by the spontaneous self-assembly of various amphiphilic block copolymers.…”
Section: Multi-responsive Micellesmentioning
confidence: 99%
“…The N/C (amine/carboxylate) ratio was kept at 1 for each solution by adding homopolymer PAsp 42 or PLL 18 in order to obtain a slightly negative charge reducing the nonspecific uptake by liver and spleen due to the electrostatic repulsion between negatively charged micelles and cellular surface.…”
Section: Multi-responsive Micellesmentioning
confidence: 99%
“…In the design of the micelles, the N/C (amine/carboxylate) ratio was kept at 1 for each solution. In detail, for the preparation of PEG-0, the calculated amount of PEG 45 -b-PLys 32 and PEG 45 -b-PAsp 36 was mixed in pure water and stirred for 0.5 hours and excess amount of EDC⋅HCl (the mole ratio is over ten times compared to the amine or carboxylate) was added to the mixture. After stirring overnight at room temperature, the solution was centrifuged three times in an Amicon Ultra-4 device (Millipore, Shanghai, People's Republic of China) with an ultrafiltration membrane (molecular weight cutoff =100 k) at a speed of 6,000 rpm for 6 minutes using Milli-Q water as the washing agent before lyophilization.…”
Section: Experimental Section Materialsmentioning
confidence: 99%
“…After stirring overnight at room temperature, the solution was centrifuged three times in an Amicon Ultra-4 device (Millipore, Shanghai, People's Republic of China) with an ultrafiltration membrane (molecular weight cutoff =100 k) at a speed of 6,000 rpm for 6 minutes using Milli-Q water as the washing agent before lyophilization. The PEG-25, PEG-50, and PEG-75 were similarly prepared through the mixing of PEG 45 -b-PLys 32 and PEG 12 …”
Section: Experimental Section Materialsmentioning
confidence: 99%
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