2021
DOI: 10.3390/polym13152457
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In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds

Abstract: Guided bone regeneration involves excluding non-osteogenic cells from the surrounding soft tissues and allowing osteogenic cells originating from native bone to inhabit the defect. The aim of this work was to fabricate, analyze antibiofilm activity and evaluate in vivo biological response of poly (lactic-co-glycolic acid) (PLGA) electrospun membranes incorporated with tea tree oil and furan-2(5H)-one. Samples were exposed to Streptococcus mutans culture and after 48 h incubation, biofilm was evaluated by colon… Show more

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Cited by 6 publications
(4 citation statements)
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“…Regarding the biodegradability of membranes in rats, Lumina-Coat confirmed the stability time of 4 to 6 weeks 11,31 , falling short of the Lumina-Coat Double Time, stable up to 8 weeks 50,56 . Surgitime PTFE did not show resorption during the experiment, as expected for the synthetic polymer PTFE 11,12,24,32,53 . Despite GenDerm being well organized, with high tensile strength and less deformation compared to Lumina-Coat and Surgidry Dental F, internal cracks explain structural fragility and greater subcutaneous degradation, predicted for up to 45 days 11,33 .…”
Section: Discussionsupporting
confidence: 73%
See 1 more Smart Citation
“…Regarding the biodegradability of membranes in rats, Lumina-Coat confirmed the stability time of 4 to 6 weeks 11,31 , falling short of the Lumina-Coat Double Time, stable up to 8 weeks 50,56 . Surgitime PTFE did not show resorption during the experiment, as expected for the synthetic polymer PTFE 11,12,24,32,53 . Despite GenDerm being well organized, with high tensile strength and less deformation compared to Lumina-Coat and Surgidry Dental F, internal cracks explain structural fragility and greater subcutaneous degradation, predicted for up to 45 days 11,33 .…”
Section: Discussionsupporting
confidence: 73%
“…Natural composite membranes with collagen and apatite also exhibit fibrogenesis similar to collagen biopolymers 17,50,52 . On the other hand, synthetic polymers present connective tissue formation dependent on the degradability pattern, in a lower fibrogenesis scale in non-resorbable biomaterials (e.g., PTFE) 11,12,24,47,53 and higher in resorbable ones (e.g., PLGA) 13,24,45,47,54,55 . None of the experimental groups had a foreign body granuloma (nonimmunogenic) with a fibrous capsule, which is considered an unwanted implant rejection response 17,18,47 .…”
Section: Discussionmentioning
confidence: 99%
“…This model is widely used in material biocompatibility assessment studies [ 17 , 32 , 33 ], since it is considered easy to handle, low-cost, and safe. In addition, this surgical site is standardized by ISO 10993-6/2016 [ 10 , 33 , 34 ] to assess the biocompatibility of biomaterials by analyzing the recruitment of inflammatory cells and also allows the understanding of how the tissue responds to the presence of membranes, as well as the chronological events of biodegradation [ 17 , 27 ]. Considering the concepts of translational research, the objective of this study is not to extrapolate the results for human use but to comprehend the behavior of membranes in terms of biocompatibility and biodegradation after implantation, supporting future research in humans.…”
Section: Discussionmentioning
confidence: 99%
“…These NPs increased the immune system ability to eliminate the bacterial biofilm. (Geremias et al, 2021) Tea tree oil and furan-2(5H)-one.…”
Section: Aggregatibacter Actinomycetemcomitansmentioning
confidence: 99%