In Vivo Biosensing: Progress and Perspectives

Rong, Guoxin; Corrie, Simon R.; Clark, Heather A.

doi:10.1021/acssensors.6b00834

Cited by 168 publications

(124 citation statements)

References 90 publications

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“…Expanded studies on dissolution kinetics of semiconductors for transient electronics were reported by Kang et al [31] The authors correlated the dissolution rates of 100 nm thick NMs of polycrystalline silicon (p-Si), amorphous silicon (a-Si), silicon-germanium alloy (SiGe), and germanium (Ge) in aqueous solutions with different pH (7)(8)(9)(10) and temperature (room temperature and 37 °C) values. Equation (2)…”

Section: Inorganic Semiconductorsmentioning

confidence: 99%

“…Besides, the continuous diffusion of noninvasive and minimally invasive sensor systems for personalized medicine and sport&wellness activities envisages an ever‐growing electronic waste that poses serious environmental hazards, given the pervasive presence and rapid turn‐over of electronic devices in everyday life . The development of biodegradable electronic components and systems that facilitate disposal by natural dissolution in ambient or mild conditions without environmental threats could mitigate electronic waste problems …”

Section: Introductionmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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Section: Inorganic Semiconductorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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“…In contrast, well-defined plasmonic substrates can also be prepared, typically through deposition on solid supports, [56,57] leading to maximized SERS signals, as well as uniform SERS enhancement factors across the entire surface, owing to their homogenous structure, so that the reproducibility of SERS analysis is greatly improved. [59,60] We present below some examples of supported SERS substrates that have been applied to the detection of monosaccharides. [59,60] We present below some examples of supported SERS substrates that have been applied to the detection of monosaccharides.…”

Section: Detection Of Saccharidesmentioning

confidence: 99%

“…[58] Such solid plasmonic substrates have been proposed for the long-term monitoring of target analytes in real biological systems. [59,60] We present below some examples of supported SERS substrates that have been applied to the detection of monosaccharides.…”

Section: Detection Of Saccharidesmentioning

confidence: 99%

Plasmonic Detection of Carbohydrate‐Mediated Biological Events

Garcı́a

Mosquera

Plou

et al. 2018

Advanced Optical Materials

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regulation of a variety of physiological and pathological processes, such as proliferation and adhesion, immune response, and cell differentiation. [8] The biological roles of carbohydrates as signaling effectors and recognition markers are associated to specific molecular recognition events in which proteins [9] or other carbohydrates [10] are involved. However, individual carbohydrate-based molecular interactions have been shown to be generally weak and, therefore, biomolecules usually present clusters of carbohydrates that interact cooperatively with their natural ligands (multivalent effect), thereby increasing the binding strength. [11] Interestingly, the multivalent carbohydrate presentation can be mimicked by man-made multivalent systems, which involve multiple synthetic oligosaccharides, [12][13][14][15][16][17] and have been used to address basic studies, but also as probe molecules and drugs. Mammalian cells are covered by a dense array of carbohydrates known as glycocalyx. The glycocalyx composition depends on the specific cellular state, and therefore it can provide information about diseases. For example, an increase of α-2,6-sialylation, fucosylation, and/or other tumor-associated carbohydrate antigens on the cellular membrane is considered as a biomarker of cancer progression, with diagnostic value. [18,19] In addition, oligosaccharides can be used as disease biomarkers for targeted therapy, and therefore the analysis and characterization of the composition of cellular glycans provide information of relevance to the diagnosis of several diseases. [20] Different strategies can be used to label glycans, including the use of covalent recognizing ligands (e.g., boronic acid), using specific carbohydrate-binding proteins, and via metabolic labeling.Plasmonics is based on the excitation of surface plasmons, that is, coherent oscillations of electrons induced by an electromagnetic radiation at metal-dielectric interfaces. [21] When the dimensions of plasmonic nanostructures are smaller than the wavelength of the incident light, the interaction between the electromagnetic field and surface charges results in nonpropagating oscillations denoted as localized surface plasmon resonances (LSPR). [22] LSPR frequencies in metal nanoparticles depend on their size, shape, organization, interparticle distance, and dielectric environment, ranging from the visible through the near-infrared (NIR). [23,24] A large volume of research has been devoted to the development of reliable methods for the preparation of plasmonic nanostructures with well-defined shape, size, and/or interparticle spacing, as basic components of various analytical applications. [25,26] Another important element, the surface chemistry of plasmonic The incorporation of nanomaterials in glycoscience research enables the design of highly selective and sensitive bioanalytical devices for the detection of disease-associated biomarkers. In particular, localized surface plasmon resonance (LSPR) and surface enhanced Raman scattering (SERS) spectroscopies ar...

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“…[3,4,8,9] Herein, af luorideselective optode based on Al III octaethylporphyrin (Al[OEP]) as the ionophore [9] is employed to demonstrate the new paperbased ISO concept. [3,4,8,9] Herein, af luorideselective optode based on Al III octaethylporphyrin (Al[OEP]) as the ionophore [9] is employed to demonstrate the new paperbased ISO concept.…”

mentioning

confidence: 99%

An Ionophore‐Based Anion‐Selective Optode Printed on Cellulose Paper

et al. 2017

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Ag eneral anion-sensing platform is reported based on ap ortable and cost-effective ion-selective optode and as martphone detector equipped with ac olor analysis app.I n contrast to traditional anion-selective optodes using ah ydrophobic polymer and/or plasticizer to dissolve hydrophobic sensing elements,the new optode relies on hydrophilic cellulose paper.The anion ionophore and alipophilic pH indicator are inkjet-printed and adsorbed on paper and form a" dry" hydrophobic sensing layer.P orous cellulose sheets also allow the sensing site to be modified with dried buffer that prevents any sample pH dependence of the observed color change.A highly selective fluoride optode using an Al III -porphyrin ionophore is examined as an initial example of this new anion sensing platform for measurements of fluoride levels in drinking water samples.A part from Lewis acid-base recognition, hydrogen bonding recognition is also compatible with this sensing platform.

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In Vivo Biosensing: Progress and Perspectives

Cited by 168 publications

References 90 publications

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Plasmonic Detection of Carbohydrate‐Mediated Biological Events

An Ionophore‐Based Anion‐Selective Optode Printed on Cellulose Paper

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