2007
DOI: 10.1097/ta.0b013e318047b805
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In Vivo Bleeding Time and In Vitro Thrombelastography Measurements are Better Indicators of Dilutional Hypothermic Coagulopathy Than Prothrombin Time

Abstract: Although satisfactory in warfarin-induced coagulopathy, PT was not a valid screening test for dilutional and hypothermic coagulopathy. BT and TEG measurements of blood clotting rate are better indicators of coagulopathic bleeding and mortality in this lethal hemorrhage model.

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Cited by 61 publications
(52 citation statements)
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“…Traumatic brain injury, as defined by head AIS ≥ 3, was present in 55% of patients. This population was severely injured with a median injury severity score of 21 (9,33). There were 76 survivors (88%) and 10 non-survivors (12%).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Traumatic brain injury, as defined by head AIS ≥ 3, was present in 55% of patients. This population was severely injured with a median injury severity score of 21 (9,33). There were 76 survivors (88%) and 10 non-survivors (12%).…”
Section: Resultsmentioning
confidence: 99%
“…Originally designed for the management of certain disease states or to guide anticoagulation therapy, CCT incompletely characterize the coagulopathy associated with severe trauma [6][7][8][9]. Additionally, there is often a significant delay in obtaining results from even emergent CCT that is suboptimal in the management of critically ill trauma patients [3,[10][11][12].…”
Section: Purposementioning
confidence: 99%
“…4 However, in a rabbit model of coagulopathy and uncontrolled bleeding from a splenic injury, bleeding time and thromboelastography (TEG) predicted lethal hemorrhage better than PT. 21 Similarly, in a swine model of hypothermia and hemorrhage induced coagulopathy, activated clotting time and TEG were better at detecting coagulation abnormalities than PT and PTT. 22 In our study, 30 minutes of hypotension followed by fluid resuscitation would result in some degree of coagulopathy, unfortunately we were not able to measure this with plasma based coagulation tests.…”
Section: Discussionmentioning
confidence: 98%
“…There is also a requirement to be able to monitor the effect of treatment in a responsive and timely manner. Assessing coagulation status in trauma patients with standard laboratory tests such as PT and aPTT for TIC are insensitive for detecting ATC or monitoring the effects of therapy and have a significant lag behind the clinical picture owing to the time delay in their performance [37,88]. There are a number of global coagulation tests such as activated clotting time and bleeding time.…”
Section: Point Of Care Testing and Monitoring In Trauma Resuscitationmentioning
confidence: 99%