In vivo changes in the rates of total lipid and fatty acid synthesis in liver and white adipose tissues of male rats during postweaning growth

Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

“…However , after puberty , liver becomes the main site for lipogenesis (Gandemier et al , 1982 ) . Fatty liver is a consequence of different causative agents , as alcohol , viral hepatitis and many other drugs .…”

Hepatic and Adipose Tissue Lipogenesis as Related to Age and Thyroid Status in the Rat

“…The number of cells undertaking the differentiating process, as well as the incorporation rate of lipogenic precursors into trigylceridefatty acids, were enhanced by addition of triiodothyronine in cell cultures of ob 17 lines (Gharbi-Chihi, Grimaldi, Torresani and Ailhaud 1981;Grimaldi, Djian, Forest, Poll, Negrel and Ailhaud 1983) and in primary cultures (unpublished results). Moreover, in vivo, de novo lipogenesis could not be correlated to fat cell size {Holm, Jacobson, (Bjorntorp and Smith 1975), but has been reported to depend on age (Gandemer, Pascal and Durand 1982) and on adipose tissue localization (Fried, Lavau and Pi-Sunyer 1981). Since, in culture, new fat cell recruitment was partly related to de novo lipogenesis stimulation, it is therefore tempting to postulate a similar relationship in vivo.…”

Influence of diet on the development and regulation of lipogenic enzymes in adipose tissue

“…The low concentration of plasma insulin during the suckling period could limit adipose tissue lipoprotein lipase activity and the marked increases of plasma insulin after weaning could play an important role in activation of lipoprotein lipase (Cryer, 1982). The rates of glucose utilization in vivo and of lipogenesis are very low in white adipose tissue during the suckling period and markedly increase after weaning onto a highcarbohydrate (HC) diet (Hahn, 1970;Tsujikawa & Kimura, 1980;Gandemer et al 1982;Issad et al 1988). Basal and insulin-stimulated glucose metabolism are also very low in isolated adipocytes during the suckling period but increase markedly after weaning onto a high-fat (HF) diet (Tsujikawa & Kimura, 1980;Issad et al 1989).…”