In vivo characteristics of low molecular weight copoly(L-lactic acid/glycolic acid) formulations with controlled release of luteinizing hormone-releasing hormone agonist

Asano, Masaharu; Fukuzaki, Hironobu; Yoshida, Minoru; Kumakura, Minoru; Mäshimo, T.; Yuasa, Hisako; Imai, Kyoichi; Yamanaka, Hidetoshi; Suzuki, Kunihiro

doi:10.1016/0168-3659(89)90002-3

Cited by 49 publications

References 27 publications

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Design and testing of a new cisplatin form using a base material by combining poly-D,L-lactic acid and polyethylene glycol acid against peritoneal metastasis

et al. 1998

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Microspheres containing cisplatin (CDDP) embedded in poly‐d,l‐lactic acid (PLA) and polyethylene glycol acid (CDDP‐PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP‐PPMS without initial burst. CDDP‐PPMS was compared with CDDP aqueous solution (CDDP‐SOL) by i.p. administration in rats for 1) tissue distribution, 2) toxicity and 3) therapeutic effects against Yoshida sarcoma. We found that the CDDP concentration in the omentum was maintained at a higher level than in the CDDP‐SOL group, while the particles of CDDP‐PPMS were observed in the stomata of the omentum by electron microscopy. Concentrations of CDDP in the lung, liver, kidney and blood were lower in the CDDP‐PPMS group than in the CDDP‐SOL group. All rats given CDDP‐PPMS containing ≤28 mg/kg were alive, whereas in the CDDP‐SOL group, all rats given ≥16 mg/kg died from side effects. The LD50 of CDDP‐PPMS and CDDP‐SOL were 32.8 and 14.8 mg/kg, respectively. The survival of rats with peritoneal metastasis was better in the CDDP‐PPMS group than in the CDDP‐SOL group. Int. J. Cancer 76:709–712, 1998.© 1998 Wiley‐Liss, Inc.

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Design and testing of a new cisplatin form using a base material by combining poly-D,L-lactic acid and polyethylene glycol acid against peritoneal metastasis

et al. 1998

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Multiblock copolymers based on segments of poly (D,L-lactic-glycolic acid) and poly(ethylene glycol) or poly(?-caprolactone): A comparison of their thermal properties and degradation behavior

Penco

Bignotti

Sartore

et al. 2000

J. Appl. Polym. Sci.

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A comparison of the thermal properties of two classes of poly(D,L‐lactic‐glycolic acid) multiblock copolymers is reported. In particular, the results of differential scanning calorimetry, and thermogravimetric analysis of copolymers containing poly(ethylene glycol) (PEG) or diol‐terminated poly(ϵ‐caprolactone) (PCDT) segments are described. The influence of the chemical structure and the length of PEG and PCDT on thermal stability, degree of crystallinity and glass transition temperature (Tg ) is discussed. Finally, an evaluation of the hydrolytic behavior in conditions mimicking the physiological environment is reported. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 1721–1728, 2000

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General Methodology for Chemical Synthesis of Polyesters

et al. 2002

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Introduction Condensation Polymerization Condensation of Hydroxy Acids Condensation of Aliphatic Diols with Dicarboxylic Acids or Anhydrides Ester Exchange Reactions Polycondensation of Diols and Acyl Chlorides Polycondensation of Aromatic Copolyesters Enzymatic Synthesis of Polyesters Ring‐opening Polymerization Thermodynamics Ring‐opening Polymerization Mechanisms Effect of Polymerization Conditions Tailoring of Macromolecular Architecture and Microstructure Side Reactions, Thermal Degradation, and Stability Synthesis of Polyester Derivatives Poly(ester‐urethanes) Poly(ester‐amides) Poly(ester‐ethers)

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In vivo characteristics of low molecular weight copoly(L-lactic acid/glycolic acid) formulations with controlled release of luteinizing hormone-releasing hormone agonist

Cited by 49 publications

References 27 publications

Design and testing of a new cisplatin form using a base material by combining poly-D,L-lactic acid and polyethylene glycol acid against peritoneal metastasis

Design and testing of a new cisplatin form using a base material by combining poly-D,L-lactic acid and polyethylene glycol acid against peritoneal metastasis

Multiblock copolymers based on segments of poly (D,L-lactic-glycolic acid) and poly(ethylene glycol) or poly(?-caprolactone): A comparison of their thermal properties and degradation behavior

General Methodology for Chemical Synthesis of Polyesters

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