2019
DOI: 10.1016/j.actbio.2019.06.050
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In vivo characterization of the deformation of the human optic nerve head using optical coherence tomography and digital volume correlation

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Cited by 46 publications
(28 citation statements)
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“…The current and the previous two studies found biaxial tension in the AL with greater strain in the x- than the y- direction and greater strain in the centre than the periphery of the AL [25,26]. The strain magnitudes in mouse AL are 50% greater than E θθ and smaller than E rr measurements of post-mortem human lamina cribrosa [14], greater than measurements of post-mortem ONH [37], and between 1/3 and 2 times the optical coherence tomographic estimates of ONH strain in patients [1719]. PPS strain magnitudes here were an order of magnitude smaller than measurements in mouse sclera farther from the AL [38,39].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The current and the previous two studies found biaxial tension in the AL with greater strain in the x- than the y- direction and greater strain in the centre than the periphery of the AL [25,26]. The strain magnitudes in mouse AL are 50% greater than E θθ and smaller than E rr measurements of post-mortem human lamina cribrosa [14], greater than measurements of post-mortem ONH [37], and between 1/3 and 2 times the optical coherence tomographic estimates of ONH strain in patients [1719]. PPS strain magnitudes here were an order of magnitude smaller than measurements in mouse sclera farther from the AL [38,39].…”
Section: Discussionmentioning
confidence: 99%
“…The strain response of the ONH to IOP change has been characterized in post-mortem human eyes [1416] and more recently directly in patient eyes [1719]. Cell-scale studies of ONH astrocyte responses to mechanical loading have been limited to two-dimensional cell culture [20–23] and more recently three-dimensional cell culture methods have been proposed [24].…”
Section: Introductionmentioning
confidence: 99%
“…The OCT imaging was performed at Johns Hopkins University's Wilmer Eye Institute in the Glaucoma Center of Excellence, and was approved by the appropriate Institutional Review Board. The following structural features were marked in the 24 radial scans to segment the tissue structures of the ONH as described in Midgett et al [48]: Bruch's membrane opening, the anterior boundary of the PLNT, the anterior LC surface, and the boundary of the imageable volume below the anterior LC surface. The manual marking were imported into Cubit (Coreform, Orem, UT, USA) to construct surface geometries using closed splines.…”
Section: Case Study For Validationmentioning
confidence: 99%
“…DVC can thus be used to extract the 3D displacements and deformations between two OCT image volumes, an undeformed reference volume, and a deformed volume. The application of DVC to the analysis of OCT images of the ONH has thus emerged as a promising way to quantify the biomechanical effects caused by increases in IOP, changes in gaze, altered intracranial pressure, loss of blood pressure, and other changes in the eye biomechanical environment of potential pathologic significance [7,[21][22][23][24][25][26][27]. However, use of DVC for posterior pole biomechanics is hampered by the difficulty in quantifying ONH deformations from OCT volumes accurately and efficiently using existing DVC techniques originally developed other purposes.…”
Section: Introductionmentioning
confidence: 99%